Key takeaways
Jatenzo (testosterone undecanoate) and Depo-Testosterone (testosterone cypionate) are both medications used for testosterone replacement therapy in adult males with low testosterone (hypogonadism). They both contain testosterone and are both Schedule III controlled substances due to their potential for misuse and dependency. However, they differ in their administration routes and dosing schedules. Jatenzo is an oral capsule taken twice daily, while Depo-Testosterone is an intramuscular injection given every 2 to 4 weeks. Jatenzo is only available as a brand-name medication, whereas Depo-Testosterone has a lower-cost generic option. Common side effects of Jatenzo include headaches and high blood pressure, while Depo-Testosterone may cause breast enlargement and acne. Both medications can increase the risk of heart attack and stroke, but Jatenzo also requires regular blood pressure monitoring due to its potential to raise blood pressure. Additionally, Jatenzo can interact with blood thinners like warfarin, increasing bleeding risks, while Depo-Testosterone can cause pain at the injection site.
