Bkemv vs. Soliris for Neuromyelitis Optica Spectrum Disorder and Myasthenia Gravis: Important Differences and Potential Risks.

Bkemv

(eculizumab)

Soliris

(eculizumab)

Summary for Bkemv

Prescription only

Bkemv (eculizumab or eculizumab-aeeb) is a biosimilar to Soliris (eculizumab). It's a complement inhibitor that's used to treat certain nerve and blood conditions. This includes myasthenia gravis, paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and neuromyelitis optica spectrum disorder. It's given as an intravenous (IV) infusion by a healthcare professional, usually weekly at first and then every 2 weeks. Common side effects can include headache, diarrhea, and upper respiratory infections.

Indications for Bkemv

Paroxysmal nocturnal hemoglobinuria (PNH) in adults
Atypical hemolytic uremic syndrome (aHUS) in adults and children
Generalized myasthenia gravis (gMG) in certain adults
Neuromyelitis optica spectrum disorder (NMOSD) in certain adults

Pros and Cons for Bkemv

Pros

Maintenance infusions are usually every 2 weeks
Can be used to treat a few different blood and nerve problems
Approved for adults and some children

Cons

Must be given as an IV infusion
Requires vaccines and REMS steps before treatment
Raises the risk of serious infections

Common Side Effects for Bkemv

PNH

Headache (44%)
Common cold symptoms (23%)
Back pain (19%)
Nausea (16%)
Feeling tired (12%)
Cough (12%)

aHUS

Headache (41%)
Diarrhea (37%)
High blood pressure (33%)
Vomiting (30%)
Common cold symptoms (27%)
Low red blood cells count (26%)
Nausea (23%)
Cough (23%)
Swelling in the arms and legs (23%)
Urinary tract infection (22%)
Fever (21%)

gMG

Headache (26%)
Cold-like symptoms (24%)
Diarrhea (15%)
Joint pain (12%)
Upper respiratory tract infection (11%)
Nausea (10%)

NMOSD

Upper respiratory tract infection (29%)
Common cold symptoms (21%)
Diarrhea (16%)
Back pain (15%)
Dizziness (15%)
Joint pain (11%)
Flu (11%)
Sore throat (10%)
Bruising (10%)

Warnings for Bkemv

Serious meningococcal infections
Risk of other serious infections
Problems after stopping treatment
Infusion reactions

Summary for Soliris

Prescription only

Soliris (eculizumab) is used to treat certain nerve problems, such as myasthenia gravis. It can also help with rare blood problems, like paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This medication is a monoclonal antibody known as a complement inhibitor. It's given as an infusion through the vein by a healthcare professional. Side effects include headache, nausea, and high blood pressure. There's also a risk of serious meningococcal infection. So, it's only available through a special program called the Soliris Risk Evaluation and Mitigation Strategy (REMS). Currenly, Soliris (eculizumab) is a brand-name medication only.

Indications for Soliris

Paroxysmal nocturnal hemoglobinuria (PNH) in adults
Atypical hemolytic uremic syndrome (aHUS) in adults and children
Generalized myasthenia gravis (gMG) in certain people who are 6 years and older
Neuromyelitis optica spectrum disorder (NMOSD)) in certain adults

Pros and Cons for Soliris

Pros

Given every week or every 2 weeks for most people
Can be given to some children with aHUS or gMG
Monitored by a healthcare professional for safety during and a little while after each infusion

Cons

Must be given as an infusion through the vein at a medical center
Need to get certain vaccines before starting treatment
Higher risk of serious infection

Common Side Effects for Soliris

PNH:

Headache (44%)
Cold-like symptoms (23%)
Back pain (19%)
Nausea (16%)
Tiredness (12%)
Cough (12%)

aHUS:

Headache (41%)
Diarrhea (37%)
Vomiting (30%)
High blood pressure (33%)
Cold-like symptoms (27%)
Anemia (26%)
Nausea (23%)
Swelling in the arms or legs (23%)
Cough (23%)
Urinary tract infection (22%)
Fever (21%)

gMG:

Headache (26%)
Cold-like symptoms (24%)
Diarrhea (15%)
Joint pain (12%)
Upper respiratory tract infection (11%)
Nausea (10%)

NMOSD:

Upper respiratory tract infection (29%)
Cold-like symptoms (21%)
Diarrhea (16%)
Dizziness (15%)
Back pain (15%)
Joint pain (11%)
Flu (11%)
Sore throat (10%)
Bruising (10%)

Warnings for Soliris

Risk of serious meningococcal infections
Risk of other serious infections
Worsening of PNH after stopping treatment
Worsening of aHUS after stopping treatment
Infusion reactions

Prices with our coupons for Bkemv vs. Soliris

Bkemv30 vials / 10mg/ml of 30ml

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Soliris4 vials / 30ml of 10mg/ml

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Bkemv vs. Soliris

Bkemv

Soliris

Summary for Bkemv

Indications for Bkemv

Pros and Cons for Bkemv

Pros

Cons

Common Side Effects for Bkemv

Warnings for Bkemv

Summary for Soliris

Indications for Soliris

Pros and Cons for Soliris

Pros

Cons

Common Side Effects for Soliris

Warnings for Soliris

Prices with our coupons for Bkemv vs. Soliris

Browse medications by letter

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Bkemv

Soliris

Summary for Bkemv

Indications for Bkemv

Pros and Cons for Bkemv

Pros

Cons

Common Side Effects for Bkemv

Warnings for Bkemv

Summary for Soliris

Indications for Soliris

Pros and Cons for Soliris

Pros

Cons

Common Side Effects for Soliris

Warnings for Soliris