Clarinex-D 12-Hour contains desloratadine (an antihistamine) and pseudoephedrine (a decongestant). It's used to treat symptoms of seasonal allergies, such as runny or stuffy nose and itchy or watery eyes, in adults and children. Clarinex-D (desloratadine / pseudoephedrine) comes as a tablet that's taken by mouth, typically every 12 hours. The most common side effects include trouble sleeping, dry mouth, and headache. Clarinex-D (desloratadine / pseudoephedrine) isn't available over the counter, but by prescription only. Clarinex-D is a brand name medication and not available as a generic.
Seasonal allergy symptoms (runny or stuffy nose, itchy nose, itchy or watery eyes) in adults and children ages 12 years and older
Clarinex-D (desloratadine / pseudoephedrine) is a combination of two medications that work together to relieve allergy symptoms.
Desloratadine is an antihistamine. It blocks histamine, a natural chemical in your body that can cause allergy symptoms, like itchy eyes, runny nose, sneezing, and hives. By blocking histamine, Clarinex-D (desloratadine / pseudoephedrine) helps relieve allergy symptoms.
Pseudoephedrine is a decongestant. It tightens blood vessels in the nose to relieve sinus pressure.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Observed during clinical practice
Abdominal or stomach pain area
chills
clay-colored stools
dark urine
difficult or labored breathing
difficulty swallowing
dizziness
elevated liver enzymes
fast heartbeat
fast, pounding, or irregular heartbeat or pulse
general tiredness and weakness
headache
irregular heartbeat
light-colored stools
loss of appetite
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
rash
redness of skin
shortness of breath
skin rash
swelling
tightness in chest
unpleasant breath odor
unusual tiredness or weakness
upper right abdominal pain
vomiting of blood
vomiting
welts
yellow eyes or skin
Symptoms of overdose
Get emergency help immediately if any of the following symptoms of overdose occur:
Increased heart rate
sleepiness or unusual drowsiness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Body aches or pain
congestion
dryness or soreness of throat
hoarseness
nervousness
restlessness
sleepiness or unusual drowsiness
tender, swollen glands in neck
trouble sitting still
voice changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Desloratadine and pseudoephedrine in Clarinex-D 12-Hour both start to work within an hour
Combines two medications into a single pill
Taken by mouth
Needs to be taken every 12 hours
Can cause trouble sleeping
Not the best choice for people with certain medical conditions (e.g., glaucoma, high blood pressure, trouble urinating)
You can take Clarinex-D (desloratadine / pseudoephedrine) with or without food. If it upsets your stomach, try taking the medication with food.
Swallow Clarinex-D (desloratadine / pseudoephedrine) tablets whole; don't crush, chew, or break the tablets. If you're having trouble swallowing the tablet whole, contact your prescriber because you'll need to be switched to a different medication.
It's best to avoid drinking alcohol while taking Clarinex-D (desloratadine / pseudoephedrine). This combination can raise your risk of feeling sleepy or dizzy. If you drink alcohol regularly and it's difficult for you to stop, talk with your healthcare team about whether there's a safer amount to drink or about safer options to treat your allergies.
Clarinex-D (desloratadine / pseudoephedrine) can interact with certain medications, such as monoamine oxidase inhibitors (MAOIs) and beta blockers. Don't start any new medications while taking Clarinex-D (desloratadine / pseudoephedrine) without talking to your care team first. They'll be able to review your medication list to see if your medications are safe to take together.
If you're pregnant or breastfeeding, don't take Clarinex-D (desloratadine / pseudoephedrine) until you've talked to a healthcare professional first. There's limited information on how safe it is to take pseudoephedrine during pregnancy. And there's a risk that taking pseudoephedrine during nursing can dry up breast milk supply.
Clarinex-D (desloratadine / pseudoephedrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Breathing problems (e.g., emphysema, long-term bronchitis) | Glaucoma | Urinary problems | Heart problems | High blood pressure | Thyroid problems | Diabetes
Clarinex-D (desloratadine / pseudoephedrine) typically doesn't cause serious side effects, but it's not the best choice for everyone. Both desloratadine and pseudoephedrine in Clarinex-D 12-Hour can worsen certain medical conditions, including heart problems, prostate problems, and dizziness. It's important to tell your care team about all of your medical conditions before starting Clarinex-D (desloratadine / pseudoephedrine). They'll weigh the risks and benefits of prescribing you Clarinex-D (desloratadine / pseudoephedrine).
Clarinex-D (desloratadine / pseudoephedrine) contains an antihistamine (desloratadine), and a decongestant (pseudoephedrine), which can be found in many other over-the-counter medications. Taking more than one antihistamine or decongestant can lead to symptoms of too much medication, including high blood pressure, anxiety or other behavior changes, confusion, seizures, hallucinations, or even death.
Tell your care team about the medications you take before starting Clarinex-D (desloratadine / pseudoephedrine) to make sure it's safe for you. Don't start any new medications while taking Clarinex-D (desloratadine / pseudoephedrine) without talking to your HCP or pharmacist. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine or decongestant, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a Poison Control Center at 1-800-222-1222.
Risk factors: Allergy to loratadine (Claritin)
Serious allergic reactions to Clarinex-D (desloratadine / pseudoephedrine) are possible, including life-threatening problems like anaphylaxis (closing of the throat). Let your care team know if you have an allergy to loratadine (Claritin) since it's chemically similar to Clarinex-D (desloratadine / pseudoephedrine). If you notice hives, a rash, swelling of the lips or tongue, or difficulty breathing after using Clarinex-D (desloratadine / pseudoephedrine), get medical help right away.
Clarinex-D (desloratadine / pseudoephedrine) isn't a good choice for people with kidney or liver problems. If you have kidney or liver problems, ask your healthcare team about other options.
Dosage | Quantity | Price as low as | Price per unit |
---|---|---|---|
2.5mg/120mg | 60 tablets | $353.75 | $5.90 |
Each tablet of Clarinex D contains 2.5 mg of desloratadine and 120 mg of pseudoephedrine
Ages 12 years and older: The typical dose is 1 tablet by mouth every 12 hours.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Currently take or have taken a monoamine oxidase inhibitor (MAOI) in the last 14 days
Currently have narrow-angle glaucoma
Currently have problems with urinating
Currently have severely high blood pressure or coronary artery disease
Seasonal allergy symptoms (runny or stuffy nose, itchy nose, itchy or watery eyes) in adults and children ages 12 years and older
Itchy nose or throat
Sneezing
Itchy or watery eyes
Runny or stuffy nose
Sinus congestion or pressure
Itchy nose or throat
Sneezing
Itchy or watery eyes
Runny or stuffy nose
Sinus congestion or pressure
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National Institute of Diabetes and Digestive and Kidney Diseases. (2017). Loratadine. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury.
Organon LLC. (2022). Clarinex-D 12 Hour- desloratadine and pseudoephedrine sulfate tablet, extended release [package insert]. DailyMed.
ScienceDirect. (n.d.). Desloratadine.
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