provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Clarinex-D Coupon - Clarinex-D 2.5mg/120mg tablet

Clarinex-D 12 Hour

desloratadine / pseudoephedrine
Used for Nasal Congestion, Allergic Rhinitis
Used for Nasal Congestion, Allergic Rhinitis

Clarinex-D 12-Hour contains desloratadine (an antihistamine) and pseudoephedrine (a decongestant). It's used to treat symptoms of seasonal allergies, such as runny or stuffy nose and itchy or watery eyes, in adults and children. Clarinex-D (desloratadine / pseudoephedrine) comes as a tablet that's taken by mouth, typically every 12 hours. The most common side effects include trouble sleeping, dry mouth, and headache. Clarinex-D (desloratadine / pseudoephedrine) isn't available over the counter, but by prescription only. Clarinex-D is a brand name medication and not available as a generic.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on August 21, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Clarinex-D (desloratadine / pseudoephedrine)?

What is Clarinex-D (desloratadine / pseudoephedrine) used for?

  • Seasonal allergy symptoms (runny or stuffy nose, itchy nose, itchy or watery eyes) in adults and children ages 12 years and older

How Clarinex-D (desloratadine / pseudoephedrine) works

Clarinex-D (desloratadine / pseudoephedrine) is a combination of two medications that work together to relieve allergy symptoms.

Are you looking for information on Clarinex (desloratadine) or Claritin-D (loratadine / pseudoephedrine) instead?

Drug Facts

Common BrandsClarinex-D
Drug ClassAntihistamine / Decongestant
Controlled Substance ClassificationControlled in some states. See FAQs below.
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$437.88(save 19.21%)
GoodRx discount
$353.75
See prices
basics-icon

What are the side effects of Clarinex-D (desloratadine / pseudoephedrine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Trouble sleeping (10%)
  • Dry mouth (8%)
  • Headache (8%)

Other Side Effects

  • Fatigue
  • Sleepiness
  • Dizziness
  • Sore throat
  • Nausea
  • Loss of appetite

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • High blood pressure or fast heart rate: chest pain, blurry vision, headache, fatigue
  • Allergic reaction: itchy, red rash (hives); shortness of breath; chest tightness; swelling of lips, tongue, throat, face, or eyes

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Observed during clinical practice

Abdominal or stomach pain area

chills

clay-colored stools

cough

dark urine

difficult or labored breathing

difficulty swallowing

dizziness

elevated liver enzymes

fast heartbeat

fast, pounding, or irregular heartbeat or pulse

fever

general tiredness and weakness

headache

hives

irregular heartbeat

itching

light-colored stools

loss of appetite

nausea

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

rash

redness of skin

shortness of breath

skin rash

swelling

tightness in chest

unpleasant breath odor

unusual tiredness or weakness

upper right abdominal pain

vomiting of blood

vomiting

welts

wheezing

yellow eyes or skin

Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

Increased heart rate

sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dry mouth

sleeplessness

trouble sleeping

unable to sleep

Less common

Body aches or pain

congestion

dryness or soreness of throat

hoarseness

nervousness

restlessness

runny nose

sleepiness or unusual drowsiness

tender, swollen glands in neck

trouble sitting still

voice changes

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Clarinex-D (desloratadine / pseudoephedrine)

thumbs-up

Pros

Desloratadine and pseudoephedrine in Clarinex-D 12-Hour both start to work within an hour

Combines two medications into a single pill

Taken by mouth

thumbs-down

Cons

Needs to be taken every 12 hours

Can cause trouble sleeping

Not the best choice for people with certain medical conditions (e.g., glaucoma, high blood pressure, trouble urinating)

pharmacist-tips

Pharmacist tips for Clarinex-D (desloratadine / pseudoephedrine)

pharmacist

  • You can take Clarinex-D (desloratadine / pseudoephedrine) with or without food. If it upsets your stomach, try taking the medication with food.

    • Swallow Clarinex-D (desloratadine / pseudoephedrine) tablets whole; don't crush, chew, or break the tablets. If you're having trouble swallowing the tablet whole, contact your prescriber because you'll need to be switched to a different medication.

      • It's best to avoid drinking alcohol while taking Clarinex-D (desloratadine / pseudoephedrine). This combination can raise your risk of feeling sleepy or dizzy. If you drink alcohol regularly and it's difficult for you to stop, talk with your healthcare team about whether there's a safer amount to drink or about safer options to treat your allergies.

        • If you're pregnant or breastfeeding, don't take Clarinex-D (desloratadine / pseudoephedrine) until you've talked to a healthcare professional first. There's limited information on how safe it is to take pseudoephedrine during pregnancy. And there's a risk that taking pseudoephedrine during nursing can dry up breast milk supply.

          faqs

          Frequently asked questions about Clarinex-D (desloratadine / pseudoephedrine)

          Is Clarinex-D (desloratadine / pseudoephedrine) over the counter?
          No, Clarinex-D (desloratadine / pseudoephedrine) is only available with a prescription from a healthcare provider. If you're looking for a combination medication containing an antihistamine and decongestant that's over the counter (or behind the counter), ask your pharmacist for available options.
          What's the difference between Clarinex-D and Claritin-D?
          Both Clarinex-D (desloratadine / pseudoephedrine) and Claritin-D (loratadine / pseudoephedrine) contain the decongestant pseudoephedrine with a different antihistamine: Clarinex-D contains desloratadine while Claritin-D contains loratadine. Desloratadine and loratadine seem to work similarly well, but some people might prefer one over the other. Another difference is that Clarinex-D is only available as a 12-hour tablet that can be taken twice daily. Claritin-D also comes as a 12-hour tablet, as well as a 24-hour tablet that's taken once daily. Additionally, Claritin-D is available over the counter (behind the counter) while Clarinex-D requires a prescription.
          Is Clarinex-D (desloratadine / pseudoephedrine) a controlled substance?
          Certain states might consider Clarinex-D (desloratadine / pseudoephedrine) a controlled substance and have put strict regulations on the medication. This is because the pseudoephedrine in Clarinex-D has the potential to be misused. Keep in mind that state laws change from time to time. So, it’s best to ask your primary care provider or pharmacist whether Clarinex-D (desloratadine / pseudoephedrine) is a controlled substance in your state and how to safely take the medication.
          Does Clarinex-D (desloratadine / pseudoephedrine) make you drowsy?
          Yes, it's possible to feel drowsy after you take Clarinex-D 12-Hour because it contains desloratadine, an antihistamine. But Clarinex-D 12-Hour also contains pseudoephedrine, which can have the opposite effect and make you stay awake. Studies show that Clarinex-D (desloratadine / pseudoephedrine) is more likely to cause insomnia (trouble sleeping) than drowsiness. Pay attention to how Clarinex-D (desloratadine / pseudoephedrine) affects your sleep. Contact your prescriber to discuss better options for you if it's making you too sleepy or interrupting your sleep and affecting your daily activities.
          Can you take Clarinex-D (desloratadine / pseudoephedrine) with acetaminophen (Tylenol) or ibuprofen (Advil)?
          Clarinex-D (desloratadine / pseudoephedrine) isn't known to have a direct interaction with acetaminophen (Tylenol) or ibuprofen (Advil). But these pain medications aren't the best choice for everyone. For example, acetaminophen (Tylenol) isn't a good option for people who have liver problems. And ibuprofen (Advil) can worsen kidney or heart problems. To be safe, it's best to ask your care team if it's appropriate for you to take Clarinex-D (desloratadine / pseudoephedrine) with acetaminophen (Tylenol) or ibuprofen (Advil).
          Can you take Clarinex-D (desloratadine / pseudoephedrine) with diphenhydramine (Benadryl)?
          No, don't take diphenhydramine (Benadryl) with Clarinex-D (desloratadine / pseudoephedrine). Diphenhydramine (Benadryl) is an antihistamine, just like desloratadine in Clarinex D. Taking multiple antihistamines raises your risk for symptoms of too much medication, which can include poor balance and agitation. To prevent accidentally taking too many similar medications, read the labels carefully of all the medications you're taking. Talk with your pharmacist if you've more questions about medication interactions.
          GoodRxEducationalIcon

          How to save using GoodRx

          Compare Prices
          1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
          Select your free coupon
          2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
          Show coupon to your pharmacist
          3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
          Get free couponLearn more
          warings-icon

          What are the risks and warnings for Clarinex-D (desloratadine / pseudoephedrine)?

          Clarinex-D (desloratadine / pseudoephedrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Worsening of medical conditions

          • Risk factors: Breathing problems (e.g., emphysema, long-term bronchitis) | Glaucoma | Urinary problems | Heart problems | High blood pressure | Thyroid problems | Diabetes

            Clarinex-D (desloratadine / pseudoephedrine) typically doesn't cause serious side effects, but it's not the best choice for everyone. Both desloratadine and pseudoephedrine in Clarinex-D 12-Hour can worsen certain medical conditions, including heart problems, prostate problems, and dizziness. It's important to tell your care team about all of your medical conditions before starting Clarinex-D (desloratadine / pseudoephedrine). They'll weigh the risks and benefits of prescribing you Clarinex-D (desloratadine / pseudoephedrine).

            risk-warning

            Accidental overdose

            Clarinex-D (desloratadine / pseudoephedrine) contains an antihistamine (desloratadine), and a decongestant (pseudoephedrine), which can be found in many other over-the-counter medications. Taking more than one antihistamine or decongestant can lead to symptoms of too much medication, including high blood pressure, anxiety or other behavior changes, confusion, seizures, hallucinations, or even death.

            Tell your care team about the medications you take before starting Clarinex-D (desloratadine / pseudoephedrine) to make sure it's safe for you. Don't start any new medications while taking Clarinex-D (desloratadine / pseudoephedrine) without talking to your HCP or pharmacist. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine or decongestant, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a Poison Control Center at 1-800-222-1222.

            risk-warning

            Allergic reactions

            • Risk factors: Allergy to loratadine (Claritin)

              Serious allergic reactions to Clarinex-D (desloratadine / pseudoephedrine) are possible, including life-threatening problems like anaphylaxis (closing of the throat). Let your care team know if you have an allergy to loratadine (Claritin) since it's chemically similar to Clarinex-D (desloratadine / pseudoephedrine). If you notice hives, a rash, swelling of the lips or tongue, or difficulty breathing after using Clarinex-D (desloratadine / pseudoephedrine), get medical help right away.

              risk-warning

              Kidney or liver problems

              Clarinex-D (desloratadine / pseudoephedrine) isn't a good choice for people with kidney or liver problems. If you have kidney or liver problems, ask your healthcare team about other options.

              dosage

              Clarinex-D (desloratadine / pseudoephedrine) dosage forms

              The average cost for 60 tablets of 2.5mg/120mg of Clarinex-D (desloratadine / pseudoephedrine) is $353.75 with a free GoodRx coupon. This is 19.21% off the average retail price of $437.88.
              tablet
              Tablet
              DosageQuantityPrice as low asPrice per unit
              2.5mg/120mg60 tablets$353.75$5.90

              Typical dosing for Clarinex-D (desloratadine / pseudoephedrine)

              Each tablet of Clarinex D contains 2.5 mg of desloratadine and 120 mg of pseudoephedrine

              • Ages 12 years and older: The typical dose is 1 tablet by mouth every 12 hours.

              interactions

              Interactions between Clarinex-D (desloratadine / pseudoephedrine) and other drugs

              Clarinex-D (desloratadine / pseudoephedrine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Clarinex-D (desloratadine / pseudoephedrine). Please note that only the generic name of each medication is listed below.

              Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

              contraindications-icon

              Clarinex-D (desloratadine / pseudoephedrine) contraindications

              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Clarinex-D (desloratadine / pseudoephedrine) will not be safe for you to take.
              alternatives

              What are alternatives to Clarinex-D (desloratadine / pseudoephedrine)?

              There are a number of medications that your doctor can prescribe in place of Clarinex-D (desloratadine / pseudoephedrine). Compare a few possible alternatives below.
              Clarinex-D (desloratadine / pseudoephedrine)
              Used for:

              • Seasonal allergy symptoms (runny or stuffy nose, itchy nose, itchy or watery eyes) in adults and children ages 12 years and older

              $353.75 Lowest GoodRx priceView Prices
              Zyrtec-D (cetirizine / pseudoephedrine)
              Used for:

              • Itchy nose or throat

              • Sneezing

              • Itchy or watery eyes

              • Runny or stuffy nose

              • Sinus congestion or pressure

              $26.05 Lowest GoodRx priceView Prices
              Allegra-D (fexofenadine / pseudoephedrine)
              Used for:

              • Itchy nose or throat

              • Sneezing

              • Itchy or watery eyes

              • Runny or stuffy nose

              • Sinus congestion or pressure

              $22.65 Lowest GoodRx priceView Prices
              images

              Clarinex-D (desloratadine / pseudoephedrine) images

              Blue And White Oval D12 - Clarinex-D 12 Hour 2.5mg-120mg Extended-Release Tablet
              This medicine is Blue And White, Oval Tablet Imprinted With "D12".Blue And White Oval D12 - Clarinex-D 12 Hour 2.5mg-120mg Extended-Release Tablet

              Get savings updates for Clarinex-D (desloratadine / pseudoephedrine)

              Receive price alerts, news, and other messages from GoodRx about Clarinex-D (desloratadine / pseudoephedrine) and other healthcare topics and relevant savings offers.

              By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

              References

              Best studies we found

              National Institute of Diabetes and Digestive and Kidney Diseases. (2017). Loratadine. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury.

              Organon LLC. (2022). Clarinex-D 12 Hour- desloratadine and pseudoephedrine sulfate tablet, extended release [package insert]. DailyMed.

              ScienceDirect. (n.d.). Desloratadine.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
              Was this page helpful?

              Browse medications

              View All

              Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.