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Cefazolin

Cefazolin Side Effects

Allison Gourley, PharmDCydnee Ng, PharmD
Reviewed by Allison Gourley, PharmD, Cydnee Ng, PharmD
Last reviewed on October 6, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Side effects aren't common. See Other.

Less Common Side Effects

Cefazolin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: itching, hives, swelling in your face or throat, chest tightness, trouble breathing
  • C. difficile infection: loose, watery stools (diarrhea), severe stomach pain, fever, nausea

Source: DailyMed

The following Cefazolin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

Bluish color

changes in skin color

pain

swelling of the foot or leg

tenderness

Incidence not known

Abdominal or stomach cramps or tenderness

back, leg, or stomach pains

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

bloating

blood in the urine or stools

bloody or cloudy urine

chest pain

chills

clay-colored stools

cloudy urine

cough

coughing up blood

dark urine

decrease in urine output or decrease in urine-concentrating ability

decreased frequency or amount of urine

diarrhea

diarrhea, watery and severe, which may also be bloody

difficult or painful urination

difficulty with breathing or swallowing

dizziness

excessive muscle tone

fast heartbeat

feeling of discomfort

fever

general body swelling

general tiredness and weakness

headache

hives

increased blood pressure

increased menstrual flow or vaginal bleeding

increased thirst

inflammation of the joints

itching

itching of the vagina or genital area

joint or muscle pain

light-colored stools

loss of appetite

lower back or side pain

muscle aches or stiffness

muscle tension or tightness

nausea or vomiting

nosebleeds

pain during sexual intercourse

pain, warmth, or burning in the fingers, toes, and legs

pale skin

paralysis

pinpoint red spots on the skin

problems with vision or hearing

prolonged bleeding from cuts

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

red irritated eyes

red or black, tarry stools

red or dark brown urine

red skin lesions, often with a purple center

red, irritated eyes

restlessness

seizures

skin rash

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stomach cramps

sudden decrease in the amount of urine

swelling of the face, fingers, or lower legs

swollen lymph glands

swollen or painful glands

thick, white vaginal discharge with no odor or with a mild odor

tightness in the chest

trouble sitting still

troubled breathing

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight loss

upper right abdominal pain

vomiting

vomiting of blood

weight gain

wheezing

yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

hives or welts

redness of the skin

sore mouth or tongue

weight loss

white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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