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Cefpodoxime

Cefpodoxime Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on May 24, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diaper rash or fungal skin rash in children (up to 9%)
  • Diarrhea (up to 7% in adults; up to 13% in children under 2 years old)
  • Nausea (3%)
  • Vomiting (2%)

Less Common Side Effects

Cefpodoxime serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing
  • Infectious diarrhea (C. difficile-related diarrhea): fever, nausea, foul-smelling diarrhea, frequent bowel movements (up to 15 times per day)
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When do Cefpodoxime possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Risk of diarrhea
Risk of nausea or vomiting

Source: DailyMed

The following Cefpodoxime side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Diarrhea

loose stools

Less common

Change in the color, amount, or odor of vaginal discharge

Rare

Abdominal or stomach cramps or tenderness

black, tarry stools

bladder pain

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody nose

bloody or cloudy urine

blurred vision

burning while urinating

chest pain

collection of blood under the skin

confusion

continuing ringing or buzzing or other unexplained noise in the ears

cough or hoarseness

cough producing mucus

dark urine

decreased urination

decreased urine output

deep, dark purple bruise

diarrhea, watery and severe, which may also be bloody

difficult or labored breathing

difficult, burning, or painful urination

difficulty with breathing or troubled breathing

dilated neck veins

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

extreme fatigue

fainting

fast, irregular, pounding, or racing heartbeat or pulse

feeling of warmth or heat

fever or chills

flushing or redness of the skin, especially on the face and neck

frequent urge to urinate

general body swelling

headache

hearing loss

heavier menstrual periods

increase in heart rate

increased thirst

increased urge to urinate during the night

increased weight

irregular breathing

irregular heartbeat

itching of the vagina or genital area

itching, pain, redness, or swelling

loss of appetite

lower back or side pain

nausea or vomiting

nervousness

noisy breathing

nosebleeds

pain

pain during sexual intercourse

pain or swelling of the treated skin

pain or tenderness around the eyes and cheekbones

pain, warmth, or burning in the fingers, toes, and legs

pale skin

pinpoint red spots on the skin

pounding in the ears

problems with vision or hearing

rapid breathing

rapid weight gain

runny nose

shortness of breath or troubled breathing

skin rash

slow or fast heartbeat

sneezing

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stuffy or runny nose

sunken eyes

sweating

swelling of the face, fingers, feet, or lower legs

swelling or puffiness of the face

swollen glands

thick, white vaginal discharge with no odor or with a mild odor

thirst

tightness of the chest or wheezing

tingling of the hands or feet

troubled breathing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

waking to urinate at night

weight gain

wheezing

wrinkled skin

yellowing of the eyes or skin

Incidence not known

Abdominal or stomach pain

blistering, peeling, or loosening of the skin

bloody, black, or tarry stools

clay-colored stools

feeling of discomfort

fever with or without chills

general feeling of tiredness or weakness

high fever

inflammation of the joints

irritation or inflammation of the eyelid

itching

joint or muscle pain

muscle aches

rectal bleeding

red skin lesions, often with a purple center

red, irritated eyes

seizures

sudden decrease in the amount of urine

swollen lymph glands

swollen or painful glands

unpleasant breath odor

vomiting of blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Accumulation of pus

acid or sour stomach

ankle, knee, or great toe joint pain

bad, unusual, or unpleasant (after) taste

belching

blemishes on the skin

bloated or full feeling

burning feeling in the chest or stomach

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in taste

constipation

cracks in the skin

decreased appetite

difficulty with moving

dry skin

excess air or gas in the stomach or intestines

fear or nervousness

feeling of constant movement of self or surroundings

frequent urge to defecate

general feeling of discomfort or illness

hair loss

headache, severe and throbbing

heartburn

hives or welts

increase in body movements

increased sweating

increased thirst

indigestion

irritation or soreness of the mouth

joint stiffness or swelling

lack or loss of strength

loss of heat from the body

lower back or side pain

muscle aching or cramping

muscle pains or stiffness

passing of gas

peeling of the skin

pimples

poor concentration

pressure in the stomach

red, sore eyes

red, swollen skin

redness of the skin

scaly skin

seeing, hearing, or feeling things that are not there

sensation of spinning

sleepiness or unusual drowsiness

sleeplessness

sore mouth or tongue

soreness or redness around the fingernails and toenails

stomach discomfort, upset, or pain

stomach upset

straining while passing stool

swelling of the abdominal or stomach area

swelling or inflammation of the mouth

swollen, red, or tender area of infection

trouble with sleeping

unable to sleep

white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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