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Ceftriaxone

Ceftriaxone Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on August 23, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Side effects aren't common. See Other Side Effects.

Less Common Side Effects

  • Inflammation at or near the injection site
  • Pain at injection site
  • Rash
  • Itching
  • Diarrhea
  • Nausea
  • Headache
  • Fever

Ceftriaxone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
  • Nervous system side effects: hallucinations (seeing or hearing things that aren't real), seizures, sudden and brief involuntary movements or twitching, not able to speak, confusion
  • C. difficile-related diarrhea: fever, stomach pain or cramps, foul-smelling diarrhea, frequent bowel movements (up to 15 times per day)
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When do Ceftriaxone possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Pain at injection site
Diarrhea

Source: DailyMed

The following Ceftriaxone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

chest pain

chills

cough

fever

painful or difficult urination

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Diarrhea

Rare

Abdominal or stomach cramps or tenderness

back, leg, or stomach pains

bleeding gums

bloating

blood in the urine or stools

bloody nose

bluish color

changes in skin color

clay-colored stools

convulsions

cough or hoarseness

dark urine

diarrhea, watery and severe, which may also be bloody

difficulty with breathing

difficulty with swallowing

dizziness

fast, irregular, pounding, or racing heartbeat or pulse

feeling of discomfort

feeling of warmth

fever with or without chills

general body swelling

general feeling of tiredness or weakness

headache

hives

increased sweating

increased thirst

inflammation of the joints

itching

loss of appetite

lower back or side pain

muscle aches

nausea or vomiting

noisy breathing

nosebleeds

pain

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

redness of the face, neck, arms, and occasionally, upper chest

shortness of breath

skin rash

swelling of the foot or leg

swollen lymph glands

tenderness

tightness in the chest

troubled breathing with exertion

unpleasant breath odor

unusual weight loss

vomiting of blood

watery or bloody diarrhea

wheezing

yellowing of the eyes or skin

Incidence not known

Blistering, peeling, or loosening of the skin

chest pain

coughing up blood

decrease in the amount of urine

excessive muscle tone

increased menstrual flow or vaginal bleeding

muscle stiffness, tension, or tightness

nosebleeds

paralysis

prolonged bleeding from cuts

red irritated eyes

red or black, tarry stools

red or dark brown urine

red skin lesions, often with a purple center

restlessness

skin rash with a general disease

swelling

trouble sitting still

unpleasant breath odor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Acid or sour stomach

belching

bloated

change in taste

dizziness

excess air or gas in the stomach or intestines

full feeling

headache

heartburn

indigestion

itching of the vagina or genital area

loss of taste

pain during sexual intercourse

passing gas

stomach discomfort, upset, or pain

thick, white vaginal discharge with no odor or with a mild odor

Incidence not known

Hives or welts

redness, swelling, or soreness of the tongue

swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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