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Cefepime

Cefepime Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on August 10, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Side effects aren't common. See Other Side Effects.

Less Common Side Effects

  • Inflammation at or near the injection site
  • Pain at injection site
  • Rash
  • Itching
  • Hives
  • Nausea
  • Diarrhea
  • Headache
  • Fever

Cefepime serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
  • Nervous system side effects: hallucinations (seeing or hearing things that aren't real), seizures, sudden and brief involuntary movements or twitching, not able to speak, confusion
  • C. difficile-related diarrhea: foul-smelling diarrhea, frequent bowel movements (up to 15 times per day), fever, stomach pain or cramps

Source: DailyMed

The following Cefepime side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Abdominal or stomach cramps

back, leg, or stomach pains

bleeding gums, nosebleeds

confusion

convulsions

dark urine

difficulty with breathing

fever, chills

general body swelling

headache

irregular heartbeats

loss of appetite

mood or mental changes

muscle cramps in the hands, arms, feet, legs, or face

nausea or vomiting

numbness and tingling around the mouth, fingertips, or feet

tremor

yellowing of the eyes or skin

Less common

Bluish color

pain, tenderness

swelling of the foot or leg

Rare

Diarrhea

inflammation or swelling

watery or bloody diarrhea

Incidence not known

Agitation

blistering, peeling, or loosening of the skin

bloody or cloudy urine

bloody, black, or tarry stools

blurred vision

change in consciousness

chest pain

cough or hoarseness

difficult or painful urination

difficulty with swallowing

dizziness

fast heartbeat

general feeling of tiredness or weakness

itching, hives

muscle twitching or jerking

paralysis

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

rhythmic movement of the muscles

seeing, hearing, or feeling things that are not there

seizures

severe sleepiness

stiff neck

sudden decrease in the amount of urine

swollen or painful glands

unpleasant breath odor

unusual bleeding or bruising

vomiting of blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Red streaks on the skin

swelling, tenderness, or pain at the injection site

Rare

Itching of the vagina or genital area

pain during sexual intercourse

redness of the skin

sore mouth or tongue

thick, white vaginal discharge with no odor or with a mild odor

white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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