Calmoseptine is part of the Skin Barrier Emollients class and treats Itching and Pain. Skin barrier emollients are used to treat eczema, skin allergies, dry skin, and itching. They work by moisturizing the skin to reduce itching and irritation. Calmoseptine is only available as a generic drug. Get Calmoseptine for as low as $5.22, which is 57% off the average retail price of $12.28 for the most common version, by using a GoodRx coupon.