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HomeHealth TopicDermatology

12 Medications That Can Make You More Sensitive to the Sun

Christina Aungst, PharmDStacia Woodcock, PharmD
Updated on January 27, 2023

Key takeaways:

  • Photosensitivity (sun sensitivity) is a possible side effect for many medications. It can lead to severe sunburns, rashes, and other types of skin damage.

  • Antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs) are common causes of sun sensitivity. Isotretinoin (Accutane), thiazide diuretics, and methotrexate can also cause photosensitivity.

  • Applying sunscreen and wearing protective clothing can help prevent photosensitivity reactions while taking these medications. Treating sunburns when they happen is also important.

Senior woman relaxing wearing a sun hat in the garden
PeopleImages/iStock via Getty Images Plus

Getting out into the sunshine has a variety of health benefits — from helping your body produce vitamin D to avoiding bouts of depression. But too much sun exposure can be harmful, particularly if you have sensitive skin. 

And some medications can make you more sensitive to sunlight, which can cause your skin to burn more easily. This side effect can happen at any time of the year and with very little sun exposure. So it’s important to know if you’re taking a medication that causes sun sensitivity, and how to protect yourself if you are.

What is sun sensitivity (photosensitivity), and why does it happen with certain medications?

Photosensitivity (sun sensitivity) is when your skin overreacts when exposed to sunlight. This usually means that you could be more sensitive to sunlight and get sunburns more easily. It might not be a mild sunburn, either. You may end up with a worse sunburn than usual, with even a little sun exposure resulting in a severe burn. If you have photosensitivity, you may develop a rash after being in the sun, as well.

There are many possible reasons photosensitivity happens. But medications can be a common culprit. If your medication has a warning to avoid sunlight or mentions photosensitivity as a possible side effect, don’t ignore it. Taking proper precautions can help prevent or limit this side effect.

12 medications can cause sun sensitivity

There are many medications that can cause sun sensitivity. Below, we’ll review 12 types of medications that typically list photosensitivity as a side effect. But keep in mind, this is not a complete list. Check with your pharmacist to see if any of your medications can make you more sensitive to the sun.

1. Antibiotics like doxycycline and ciprofloxacin

Antibiotics and sun exposure typically don’t mix well. But there are a few that are particularly notorious for sun sensitivity.

Tetracycline antibiotics, especially doxycycline (Vibramycin, Oracea), cause sun sensitivity. This usually appears as a sunburn that sets in faster, or is more severe, than usual. But in rare cases, sun exposure while taking tetracyclines can cause fingernails or toenails to separate from the nail bed. There is some evidence that higher doses make photosensitivity more likely. Symptoms of doxycycline sun sensitivity seem to resolve about 10 to 14 days after stopping the medication.

Fluoroquinolones (“quinolones”), such as ciprofloxacin (Cipro), are another group of antibiotics that can make you more sensitive to the sun. Usually, a bad sunburn is what most people experience with quinolones and sun exposure. Sun sensitivity from quinolones typically ends about a week after you stop taking it.

On the upside, common penicillin antibiotics, like amoxicillin and amoxicillin/clavulanate (Augmentin), aren’t likely to cause this side effect. Neither one lists photosensitivity in its list of side effects.

2. Nonsteroidal anti-inflammatory drugs like naproxen

Nonsteroidal anti-inflammatory drugs (NSAIDs), like naproxen (Aleve, Naprosyn), are some of the most common pain relievers. They’re also a very common cause of photosensitivity.

Naproxen can cause you to burn more easily, or cause small blisters to appear after sun exposure. Diclofenac (Cambia, Cataflam) can cause nails to separate from the nail beds. Piroxicam (Feldene) may cause an eczema-like rash to appear. On the other hand, ibuprofen (Advil, Motrin) is very unlikely to cause sun sensitivity.

3. Accutane (isotretinoin)

Sun sensitivity is a common side effect of the oral acne medication isotretinoin (Accutane). Isotretinoin makes the skin more sensitive in general. This makes it more likely that you’ll get a sunburn while taking it.

4. Retin-A (tretinoin)

Tretinoin (Retin-A) is another acne medication that’s applied topically. It also causes sun sensitivity as a side effect. Similar to isotretinoin, you’re more likely to get a sunburn with tretinoin treatment. And, you may burn faster or easier than you would without the medication.

5. Thiazide diuretics like hydrochlorothiazide

Thiazide diuretics, especially hydrochlorothiazide (HCTZ), can cause a few different photosensitivity reactions. They can cause you to sunburn more easily or severely. They can also cause eczema-like rashes and darkened patches to appear after sun exposure. There are some reports that these rashes and skin changes can last for months to years after stopping thiazides.

6. Certain diabetes medications

Photosensitivity has also been reported with some diabetes medications. Sulfonylureas, such as glyburide and glipizide, can cause small, blister-like patches to appear after sun exposure. These can last for weeks to months after stopping the medications.

Sun sensitivity has also been reported with metformin and sitagliptin (Januvia). But these reactions are very rare, with only a small number of people having experienced them. It’s unlikely that you’d notice sun sensitivity with these two medications, but it’s still possible.

7. Tricyclic antidepressants

Tricyclic antidepressants (TCAs), such as amitriptyline, have been available for several decades. There are reports of these medications causing skin reddening and widespread rashes. Some TCAs may also cause a purple or gray skin discoloration after sun exposure.

8. Older antihistamines

Antihistamines are also a potential cause of sun sensitivity. This side effect has been documented with newer antihistamines, like loratadine (Claritin). But certain older antihistamines, like promethazine, seem to be more strongly linked to it.

Promethazine, a prescription-only nausea medication, can cause bodywide rashes that appear after sun exposure. In some cases, these rashes continued to come and go for weeks or months after stopping the medication.

9. Methotrexate

Methotrexate can be prescribed for different autoimmune disorders and cancers. Like many of the above medications, it can also make it easier for you to burn. But methotrexate has a unique photosensitivity. It can reactivate old burns. So if you were previously sunburned, or received radiation as a cancer treatment, methotrexate can cause these burns to return.

10. Amiodarone

Amiodarone (Pacerone) is a medication that can help treat arrhythmias (abnormal heart rhythms). It’s well-known for causing side effects, with sun sensitivity being one. Amiodarone can make sunburns more likely. But long-term treatment combined with sun exposure can also lead to a blue-gray skin discoloration.

11. Griseofulvin

Griseofulvin (Gris-PEG) is an antifungal that’s prescribed when other treatments aren’t working. Sun sensitivity from griseofulvin typically appears as a rash. This side effect may be more severe for people living with lupus.

12. Quinine

The malaria medication quinine (Qualaquin) can cause a variety of photosensitivity reactions. It can lead to severe sunburns, rashes, and eczema-like symptoms. It can also cause a separation of nails from the nail beds. These reactions have also been reported by people drinking tonic water (quinine-flavored, carbonated water). Quinine sun sensitivity may last for several months after stopping the medication or tonic water.

How can I protect myself when taking a sun sensitive medication?

When you’re taking a medication that can cause sun sensitivity, you’ll want to lower your risk for sunburns. First, avoid direct exposure to the sun. Stay away from tanning beds, too.

When you do spend time outside, wear sunscreen. Protective clothing like long sleeves, pants, and wide-brimmed hats can also help. And don’t forget sunglasses to protect your eyes. Using an umbrella can offer even more protection when combined with sunscreen and protective clothing.

If you do get a sunburn, know how to treat it. Apply cool compresses and drink extra water to make sure you don’t get dehydrated. You can’t speed up healing, but topical aloe vera gel can help relieve irritation.

Contact your healthcare provider if you have symptoms of a more severe burn. This may include fever, chills, and blistering or peeling of the skin.

The bottom line

There are many medications that can make your skin more sensitive to the sun. Antibiotics, NSAIDs, and thiazide diuretics are some common causes of sun sensitivity. Methotrexate, isotretinoin, and sulfonylureas can also cause this side effect. If you’re not sure whether your medication can cause sun sensitivity, double check with your pharmacist or healthcare provider. Be sure to protect yourself from the sun with sunscreen and protective clothes while taking these medications. 

References

Alrashidi, A. (2020). Prevalence and prediction of drug-induced photosensitivity. University of Manchester.

American Academy of Dermatology Association. (2021). Isotretinoin: FAQs.

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