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Bicillin CR

Bicillin CR Side Effects

Michelle Nguyen, PharmDCydnee Ng, PharmD
Reviewed by Michelle Nguyen, PharmD, Cydnee Ng, PharmD
Last reviewed on April 23, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain where the medication is injected
  • Inflammation or swelling where the medication is injected

Less Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Shortness of breath
  • Sweating
  • Fainting
  • Headache
  • Nervousness
  • Tremors
  • Dizziness
  • Sleepiness
  • Numbness or tingling
  • Itchiness
  • Rash
  • Changes in vision
  • Low blood pressure
  • Fast heart rate or a racing heart

Bicillin CR serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: hives, trouble breathing, swelling in your face and neck, tight feeling in the throat
  • Severe skin reaction: new painful rash, rash with fever, blisters, sores inside your mouth, peeling skin
  • Blood problem (methemoglobinemia): pale, gray, or blue-colored skin; headache; lightheadedness; fast heartbeat; shortness of breath; tiredness
  • Severe infectious diarrhea: very watery or loose stools, foul-smelling diarrhea, very frequent bowel movements, stomach cramps, fever

Source: DailyMed

The following Bicillin CR side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Less common

Fast or irregular breathing

fever

joint pain

lightheadedness or fainting (sudden)

puffiness or swelling around the face

red, scaly skin

shortness of breath

skin rash, hives, itching

Check with your doctor immediately if any of the following side effects occur:

Rare

Abdominal or stomach cramps and pain (severe)

abdominal tenderness

convulsions (seizures)

decreased amount of urine

diarrhea (watery and severe), which may also be bloody

mental depression

nausea and vomiting

pain at place of injection

sore throat and fever

unusual bleeding or bruising

yellow eyes or skin

Rare

For penicillin G procaine only

Agitation or combativeness

anxiety

confusion

fear of impending death

feeling, hearing, or seeing things that are not real

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea (mild)

headache

sore mouth or tongue

vaginal itching and discharge

white patches in the mouth and/or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Michelle Nguyen, PharmD, has been a clinical pharmacist for 6 years (and counting). She has a diverse skill set within managed care pharmacy, specifically in the settings of a medical group, pharmacy benefit manager (PBM), and health plan.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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