The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Pain at injection site (16% for IM injections, 3% for IV injections)
- Diarrhea (3%)
- Rash (up to 2%)
Less Common Side Effects
- Nausea
- Vomiting
- Headache
- Chest pain
- Itching
- Yeast infection
Unasyn serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction or serious skin reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, trouble breathing
- Infectious (C. difficile-related) diarrhea: rapid heart rate, foul-smelling diarrhea, frequent bowel movements (even up to 15 times per day), fever, nausea
- Liver problems: nausea, stomach pain, yellow skin or whites of the eyes, clay-colored stool, dark urine
Source: DailyMed
The following Unasyn side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Severe diarrhea, fever
- Unusual vaginal discharge, itching, or odor
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

