What should I watch for?
Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work and urine testing done while you are taking this medicine.
During your treatment, let your health care professional know if you have any unusual symptoms, such as difficulty breathing.
This medicine may rarely cause 'gastrointestinal perforation' (holes in the stomach, intestines or colon), a serious side effect requiring surgery to repair.
This medicine should be started at least 28 days following major surgery and the site of the surgery should be totally healed. Check with your doctor before scheduling dental work or surgery while you are receiving this treatment. Talk to your doctor if you have recently had surgery or if you have a wound that has not healed.
Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.
This medicine has caused ovarian failure in some women. This medicine may interfere with the ability to have a child. You should talk to your doctor or health care professional if you are concerned about your fertility.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Black, tarry stools
body aches or pain
burning, tingling, numbness, or pain in the hands, arms, feet, or legs
chest pain or discomfort
cracks in the skin
decreased urine output
difficult or labored breathing
dilated neck veins
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
lack or loss of strength
loss of appetite
loss of heat from the body
loss of voice
pain, redness, or swelling in the arm or leg
painful or difficult urination
pinpoint red spots on the skin
pounding in the ears
sensation of pins and needles
slow or fast heartbeat
sores on the skin
sores, ulcers, or white spots on the lips or in the mouth
swelling of the face, fingers, feet, or lower legs
swelling or inflammation of the mouth
tightness in the chest
unusual bleeding or bruising
unusual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
watery or bloody diarrhea
Abdominal or stomach pain or tenderness
difficulty with swallowing
muscle pain or cramps
Incidence not known
Bloody mucus or unexplained nosebleeds
sudden weakness in the arms or legs
sudden, severe chest pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.