The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Wet AMD:
- Blood on the whites of the eyes (7%)
- Cataract (3%)
- Eye floaters (3%)
- Eye pain (3%)
- Raised eye pressure (3%)
- Retinal tear (3%)
- Vitreous detachment (3%)
DME:
- Cataract (15%)
- Blood on the whites of the eyes (8%)
- Vitreous detachment (5%)
- Eye floaters (4%)
- Raised eye pressure (4%)
- Eye pain (3%)
Macular edema following RVO:
- Blood on the whites of the eyes (3%)
Less Common Side Effects
Wet AMD:
- Eye inflammation
- Eye irritation
- More tears in the eye
- Eye discomfort
DME:
- Eye inflammation
- Eye irritation
- More tears in the eye
- Eye discomfort
Macular edema following RVO:
- Vitreous detachment
- Eye floaters
- Raised eye pressure
- Eye inflammation
- Eye pain
- Cataract
- Eye discomfort
Vabysmo serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Eye infection or retinal detachment: eye redness, eye pain, light sensitivity, vision changes
- Stroke: sudden numbness or weakness on one side of the body; sudden confusion; trouble speaking, seeing, or walking; sudden severe headache
- Heart attack: chest pain or discomfort; weakness or lightheadedness; shortness of breath; pain or discomfort in the jaw, neck, back, arms or shoulders
Source: DailyMed
The following Vabysmo side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
- New or worsening eye pain, redness, irritation, or discharge
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Blurry vision
- Eye irritation or itching
- Increased tears after use


