Skip to main content

Arexvy

RSV vaccine
Used for RSV

Arexvy (RSV vaccine) is the first FDA-approved vaccine to help lower your risk of getting serious lung infections caused by respiratory syncytial virus (RSV). You can get it if you're age 60 or older, and in some cases starting at age 18 if you have a higher risk of severe illness from RSV. Arexvy (RSV vaccine) is given once as a single injection into the muscle. Common side effects include tiredness, muscle pain, and injection site reactions like pain, swelling, or redness.

Reviewed by:Last reviewed on March 16, 2026
basics-icon

What is Arexvy (RSV vaccine)?

What is Arexvy (RSV vaccine) used for?

Prevention of serious lung infections caused by respiratory syncytial virus (RSV) in:

  • Adults 60 years and older
  • Adults 18 to 59 years old who have a higher risk of illness due to RSV

How Arexvy (RSV vaccine) works

Arexvy (RSV vaccine) is a recombinant protein vaccine. It contains proteins from the RSV virus that trigger your immune system to make antibodies to fight the virus. If you’re exposed to RSV later, these antibodies can stop the virus from infecting your lungs.

Drug facts

Common BrandsArexvy
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Arexvy (RSV vaccine)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

18 to 49 years old:

  • Pain at the injection site (76%)
  • Muscle pain (60%)
  • Tiredness (60%)
  • Headache (44%)
  • Joint pain (28%)

50 to 59 years old:

  • Pain at the injection site (76%)
  • Tiredness (40%)
  • Muscle pain (36%)
  • Headache (32%)
  • Joint pain (23%)

60 years and older:

  • Pain at the injection site (61%)
  • Tiredness (34%)
  • Muscle pain (29%)
  • Headache (27%)
  • Joint pain (18%)

Less Common Side Effects

  • Redness at the injection site
  • Swelling at the injection site
  • Fever

Arexvy (RSV vaccine) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: rash, hives, racing heart, trouble breathing, swelling of the face or tongue
When do Arexvy (RSV vaccine) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Pain at the injection site
Feeling tired
Muscle pain
Joint pain
Headache

Source: DailyMed

The following Arexvy (RSV vaccine) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Feeling faint or lightheaded
  • Weakness and tingling in the feet and legs that spreads to upper body

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

prices-container

Get your GoodRx coupon

Avg retail price
$359.72(Save 13.25%)
GoodRx discount
$312.07
See prices
pros-and-cons-icon

Pros and cons of Arexvy (RSV vaccine)

Pros

  • Reduces the risk of RSV-related lung infections
  • Only need one dose
  • Can be given with other vaccines

Cons

  • Injection might be uncomfortable
  • Common side effects include tiredness and muscle pain
  • Not approved for use in pregnancy
pharmacist-tips-icon

Pharmacist tips for Arexvy (RSV vaccine)

pharmacist
  • Arexvy (RSV vaccine) is given as a one-time shot into the muscle. You don't need a second dose at this time.
  • Injectable vaccines like Arexvy (RSV vaccine) can sometimes make people feel lightheaded or faint. After getting the shot, stay seated for some time and stand up slowly to make sure you feel okay.
  • After getting Arexvy (RSV vaccine), you might experience redness, swelling, or pain where the shot was given. This is called an injection site reaction and usually goes away in a few days.
  • If you notice any unusual or serious side effects after getting Arexvy (RSV vaccine), tell your healthcare professional right away. You can also report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 or https://vaers.hhs.gov/.
  • If you have a weakened immune system or take medications that weaken your immune system, Arexvy (RSV vaccine) might not work as well for you. Talk to your healthcare professional about what this means for your protection against RSV.
warnings-icon

Risks and warnings for Arexvy (RSV vaccine)

Arexvy (RSV vaccine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Guillain-Barré syndrome

Some people who got Arexvy (RSV vaccine) developed a rare condition called Guillain-Barré syndrome (GBS), where the immune system mistakenly attacks the nerves. This is most likely to happen within the first 42 days after getting the vaccine. If you notice symptoms like muscle weakness, tingling, and coordination problems, contact your healthcare professional right away.

Severe allergic reaction

Although rare, it's possible for Arexvy (RSV vaccine) to cause a severe allergic reaction. Get medical help right away if you experience skin rash, tightness in your chest, trouble breathing, or swelling in your lips, tongue, throat, or face after receiving this vaccine.

Fainting

Injectable vaccines like Arexvy (RSV vaccine) can cause some people to faint afterwards. Stay seated for a while after getting your vaccine, and stand up slowly to make sure you don't fall if you feel faint or dizzy.

Weaker vaccine protection

  • Risk factors: Medical conditions that weaken the immune system | Taking medications that weaken your immune system

Arexvy (RSV vaccine) might not work as well if you have a weakened immune system. If you have certain medical conditions like human immunodeficiency virus (HIV), cancer) or take medications that weaken your immune system — such as high-dose corticosteroids, transplant medications, cancer treatments) — talk to your healthcare professional first before getting Arexvy (RSV vaccine). They can help you decide if the vaccine is right for you.

dosage-icon

Arexvy (RSV vaccine) dosage

The average cost for 1 carton of 1 dose of Arexvy (RSV vaccine) is $312.07 with a free GoodRx coupon. This is 13.25% off the average retail price of $359.72.
cartonCarton
DosageQuantityPrice as low asPrice per unit
1 dose1 carton$312.07$312.07

Typical dosage for Arexvy (RSV vaccine)

The typical dose is 0.5 mL injected into the muscle by a healthcare professional.

cost-icon

How much does Arexvy (RSV vaccine) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
alternatives-icon

What are alternatives to Arexvy (RSV vaccine)?

There are a number of medications that your doctor can prescribe in place of Arexvy (RSV vaccine). Compare a few possible alternatives below.
Arexvy (RSV vaccine)
Used for:

Prevention of serious lung infections caused by respiratory syncytial virus (RSV) in:

  • Adults 60 years and older
  • Adults 18 to 59 years old who have a higher risk of illness due to RSV
$312.07Lowest GoodRx priceView prices
Used for:

Prevention of serious lung infections caused by respiratory syncytial virus (RSV) in:

  • Adults 60 years and older
  • Adults 18 to 59 years old who have a higher risk of illness due to RSV
  • Pregnant mothers between 32 to 36 weeks gestation
$325.99Lowest GoodRx priceView prices
Used for:
$312.82Lowest GoodRx priceView prices
latest-news-icon

News about Arexvy (RSV vaccine)

References

Best studies we found

Centers for Disease Control and Prevention. (2025). RSV Vaccine Guidance for Adults.

Centers for Disease Control and Prevention. (2025). Vaccines for Adults.

GlaxoSmithKline Biologicals SA. (2026). Arexvy- respiratory syncytial virus vaccine recombinant, adjuvanted kit [package insert].

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.