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Zanosar
Streptozocin
Zanosar is part of the Alkylating Drugs class and treats Pancreatic Cancer. Alkylating drugs are used to treat brain tumors, melanoma, Hodgkin's disease, Non-Hodgkin's lymphoma, breast cancer, ovarian cancer, neuroblastoma, leukemia, multiple myeloma, retinoblastoma, and prostate cancer. They work by inhibiting cancer cell growth and slowing it down. Zanosar is only available as a brand name drug. Compare alkylating drugs.
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What is Zanosar?

Commonly Used Brand Name(s)Zanosar

Therapeutic ClassificationsAntineoplastic Agent

Pharmacologic ClassificationsAlkylating Agent

Blackbox Warning

Intravenous route (Powder for Solution)

Streptozocin should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Renal toxicity from streptozocin is dose-related and cumulative and may be severe or fatal. Other major toxicities are nausea and vomiting which may be severe and at times treatment-limiting. In addition, liver dysfunction, diarrhea, and hematological changes have been observed in some patients. Streptozocin is mutagenic, and when administered parenterally, it has been found to be tumorigenic or carcinogenic in some rodents. The physician must judge the possible benefit to the patient against the known toxic effects of this drug in considering the advisability of therapy with streptozocin. The physician should be familiar with the following text before making a judgment and beginning treatment .

Overview

Streptozocin belongs to the group of medicines known as alkylating agents. It is used to treat cancer of the pancreas.

Streptozocin seems to interfere with the growth of cancer cells, which are eventually destroyed. It also directly affects the way the pancreas works. Since the growth of normal body cells may also be affected by streptozocin, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with streptozocin, you and your doctor should talk about the good this medicine will do as well as the risks of using it.

Streptozocin is to be given only by or under the immediate supervision of your doctor.

Proper Use

While you are receiving streptozocin, your doctor may want you to drink extra fluids so that you will pass more urine. This will help prevent kidney problems and keep your kidneys working well.

This medicine usually causes nausea and vomiting, which may be severe. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no specific information comparing use of streptozocin in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of streptozocin in the elderly with use in other age groups.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Infection—Streptozocin can decrease your body's ability to fight infection

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for any unwanted effects.

While you are being treated with streptozocin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Streptozocin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other people living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

If streptozocin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the health care professional right away if you notice redness, pain, or swelling at the place of injection.

Chemical Classifications

Nitrosourea

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