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Yuflyma Coupon - Yuflyma 1 autoinjector of 40mg/0.4ml carton

Yuflyma

adalimumab-aaty
Used for Plaque Psoriasis, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Ankylosing Spondylitis, Hidradenitis Suppurativa, Juvenile Idiopathic Arthritis, Uveitis
Used for Plaque Psoriasis, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Ankylosing Spondylitis, Hidradenitis Suppurativa, Juvenile Idiopathic Arthritis, Uveitis

Yuflyma (adalimumab or adalimumab-aaty) is an injectable medication used to treat multiple autoimmune and inflammatory conditions, like rheumatoid arthritis (RA) and ulcerative colitis (UC). It's a biosimilar to Humira (adalimumab). Yuflyma (adalimumab) is available in a high-concentration formulation, meaning there's more medication in less liquid. It's also citrate-free, so it should cause less pain after injection.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on June 7, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Yuflyma (adalimumab)?

What is Yuflyma (adalimumab) used for?

  • Rheumatoid arthritis (RA) - adults only

  • Juvenile idiopathic arthritis (JIA) - people age 2 and older

  • Psoriatic arthritis (PsA) - adults only

  • Ankylosing spondylitis (AS) - adults only

  • Crohn's disease (CD) - people age 6 and older

  • Ulcerative colitis (UC) - adults only

  • Plaque psoriasis - adults only

  • Hidradenitis suppurativa - adults only

  • Uveitis - adults only

How Yuflyma (adalimumab) works

Yuflyma (adalimumab) is a biologic disease-modifying antirheumatic drug (DMARD). It blocks tumor necrosis factor (TNF), which is a protein in your body that plays a role in inflammation. By blocking TNF, Yuflyma (adalimumab) lowers inflammation to relieve symptoms in different parts of your body.

Are you looking for information on Humira (adalimumab) instead?

Drug Facts

Common BrandsYuflyma
Drug ClassBiologic DMARD
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Yuflyma (adalimumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Injection site reaction (20%)
  • Upper respiratory tract infection (17%)
  • Headache (12%)
  • Rash (12%)
  • Sinus inflammation (11%)
  • Accidental injury (10%)
  • Nausea (9%)
  • Urinary tract infection (UTI) or bladder infection (8%)

Other Side Effects

  • High cholesterol
  • High blood pressure
  • Back pain
  • Stomach pain
  • Hair loss
  • Blood in the urine
  • Flu-like symptoms

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
  • Low blood cell counts: fever that doesn't go away, easy bruising or bleeding, pale skin
  • Severe allergic reaction: rash, trouble breathing, swelling of your face, eyes, lips, or mouth, hives
  • Heart failure: shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness, sudden weight gain
  • Liver problems: feeling tired, vomiting, yellow skin or whites of the eyes, stomach pain

Source: DailyMed.

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

cough

ear congestion

gas with stomach pain

hoarseness

lightheadedness

loss of voice

lower back or side pain

muscle aches and pains

pain or tenderness around the eyes or cheekbones

rapid and sometimes shallow breathing

shivering

stomach fullness

stuffy nose

sunken eyes

thirst

trouble sleeping

warmth on the skin

wrinkled skin

Less common

Abnormal vaginal bleeding or discharge

agitation

arm, back, or jaw pain

black, tarry stools

bleeding from the gums or nose

blindness

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the stool or change in bowel habits

bloody or cloudy urine

blurred vision

broken bones

change in size, shape, or color of an existing mole

change in skin color

chest pain, tightness, or heaviness

chills

clear or bloody discharge from the nipple

cold hands and feet

confusion

constipation

cough

coughing or spitting up blood

decreased urination

decreased vision

depression

difficulty with breathing

difficulty, burning, or painful urination

dimpling of the breast skin

dizziness

drowsiness

eye pain

fainting

fast, slow, or irregular heartbeat

fever

forgetfulness

frequent urge to urinate

general feeling of illness

hair loss

headache

hives, itching, skin rash

increased thirst

inverted nipple

irregular breathing

irregular pulse

irritability

light colored stools

loss of appetite

lump in the breast or under your arm

lump or swelling in the stomach

mole that leaks fluid or bleeds

muscle cramps or spasms

nausea

new mole

night sweats

no blood pressure or pulse

noisy breathing

numbness or tingling in your arms, legs, or face

pain, redness, or swelling in the arms or legs without any injury present

pale skin

persistent non-healing sore on your skin

pink growth

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised, firm, or bright red patch

redness or swelling of the breast

seeing or hearing things that are not there

seizures

sharp back pain just below your ribs

shiny bump on your skin

slurred speech or problems with swallowing

sneezing

sore on the skin of the breast that does not heal

sore throat

sores, ulcers, or white spots on the lips or mouth

spitting up blood

stiff neck

stomach pain

stopping of the heart

sudden high fever or low grade fever for months

sweating

swelling of the face, fingers, feet, or lower legs

swollen glands

swollen neck veins

tiredness

trouble breathing

trouble thinking

unconsciousness

unexplained bruising or bleeding

unpleasant breath odor

unusual tiredness or weakness

unusual weight gain or loss

visual disturbances

vomiting

vomiting of blood or material that looks like coffee grounds

yellow skin or eyes

Incidence not known

Blistering, peeling, or loosening of the skin

diarrhea

inability to move the arms and legs

joint or muscle pain

pinpoint red spots on the skin

red skin lesions, often with a purple center

red, irritated eyes

red, scaling, or crusted skin

sudden numbness and weakness in the arms and legs

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bladder pain

bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

pounding in the ears

Less common

Abnormal healing

decrease in height

difficulty with moving

difficulty with walking

dry mouth

heartburn

indigestion

loss of hearing

loss of strength or energy

menstrual changes

muscle or joint stiffness, tightness, or rigidity

muscle pain or weakness

pain in the back, ribs, arms, or legs

shakiness in the legs, arms, hands, and feet

swelling or redness in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Yuflyma (adalimumab)

thumbs-up

Pros

Can be given at home (if your provider says it's safe to do so)

Only needs to be injected a few times per month

Conveniently available as a prefilled syringe or autoinjector

Available as a citrate-free formulation, so injections should be less painful

thumbs-down

Cons

Raises the risk of serious infections

Might be difficult to use for some people

Must avoid live vaccines while taking the medication

Not known if it's safe in pregnancy or breastfeeding

pharmacist-tips

Pharmacist tips for Yuflyma (adalimumab)

pharmacist

  • Before using Yuflyma (adalimumab) at home, you should receive injection training from your healthcare provider or care team. Don't try to give yourself an injection until you've been shown how to do it correctly and you're familiar with the Instructions for Use. If you have questions, call your provider or 1-877-888-4231.

    • Use a calendar to mark when your doses of Yuflyma (adalimumab) are due. This medication works best when it's taken consistently.

      • When you're ready for your dose, take Yuflyma (adalimumab) out of the refrigerator and let it warm up to room temperature for about 15 to 30 minutes. This can reduce discomfort with the injection. Don't warm it up by putting it in the microwave or in hot water and don't shake it because this could damage the medication.

        • Always check to see if the Yuflyma (adalimumab) liquid is clear or pale brown and free of particles. Don't use it if it has another color or contains particles.

          • Keep unused Yuflyma (adalimumab) in the refrigerator in its original container to protect it from light. You can store it at room temperature for 30 days, just make sure to throw it away after that time.

            • Throw away used needles, syringes, and autoinjectors in a sharps container to prevent needlestick injuries. You can use an FDA-cleared container or heavy-duty plastic container you have at home. Check your local laws and guidelines for how to dispose of your container once it's almost full.

              • Before getting any vaccines, let your provider or pharmacist know you're taking Yuflyma (adalimumab). It's recommended to avoid live vaccines while you're taking this medication. Make sure your child gets all of their appropriate shots before starting Yuflyma (adalimumab).

                faqs

                Frequently asked questions about Yuflyma (adalimumab)

                When will Yuflyma (adalimumab) be available?
                According to the manufacturer, Yuflyma (adalimumab) is expected to be available in the United States starting July 2023. It was approved by the FDA in May 2023.
                Where can I inject Yuflyma (adalimumab)?
                You can inject Yuflyma (adalimumab) into the fatty area under the skin of your lower stomach (at least 2 inches away from your belly button) or on the front of your thighs. Rotate the injection sites each time so your skin has time to heal. Don't inject the medication into skin that's sore, hard, red, or bruised.
                What's the difference between Yuflyma (adalimumab) and Humira (adalimumab)?
                Humira (adalimumab) is the original FDA-approved medication, and it was later followed by many biosimilars (including Yuflyma (adalimumab)). Yuflyma (adalimumab) has a comparable structure and works similarly to Humira (adalimumab). You can sort of think about biosimilars like generics, except they're not identical to the original biologic. Both medications treat similar autoimmune and inflammatory conditions, but Yuflyma (adalimumab) isn't FDA approved to treat all age groups within a condition that Humira (adalimumab) is.
                What should I do if I miss a dose of Yuflyma (adalimumab)?
                If you forgot to take your dose of Yuflyma (adalimumab), give yourself the dose as soon as possible. Then, return to your normal dosing schedule. If you have questions about when you should take your dose, contact your pharmacist or provider.
                How long can Yuflyma (adalimumab) be at room temperature?
                Yuflyma (adalimumab) should be stored in the refrigerator. But if you need to travel or won't have access to a refrigerator, it can be kept at room temperature for up to 30 days. After this time it should be thrown away because it might not work as well anymore. You can write down the date you took Yuflyma (adalimumab) out of the refrigerator to keep track of when the 30 days are over. Be sure to always protect the medication from light by keeping it in its original packaging until you're ready to use it.
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                What are the risks and warnings for Yuflyma (adalimumab)?

                Yuflyma (adalimumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Serious infections

                • Risk factors: Taking other medications that weaken the immune system | Older adults | Active, long-term, or an infection that keeps coming back | Traveling to high risk areas | Having other conditions that raise the risk of infection

                  Yuflyma (adalimumab) can raise your risk of serious infections that can lead to hospitalization or death. Your risk is higher if you're an older adult, taking other medications that can weaken the immune system (e.g., methotrexate, Orencia (abatacept), Kineret (anakinra), corticosteroids), or if you have other health conditions. For your safety, discuss your medical history with your provider. Be sure to let them know if you've ever had tuberculosis or hepatitis B. They'll review your risk before starting the medication. If you develop a serious infection while taking Yuflyma (adalimumab), you might have to stop the medication in order to give your immune system a chance to fight the infection.

                  risk-warning

                  Cancers

                  • Risk factors: Taking other medications that weaken the immune system | History of cancer | People with chronic obstructive pulmonary disease (COPD) with a history of smoking

                    During clinical studies with a medication like Yuflyma (adalimumab), there was a greater number of people who developed cancer while taking that medication when compared to people not taking it. Lymphoma, leukemia, and skin cancers were some of the most commonly reported types of cancer in people who used that medication. Your provider will determine your risk before starting Yuflyma (adalimumab) and monitor you while you're taking it. Speak to your provider if you have any concerns.

                    risk-warning

                    Severe allergic reactions

                    Products containing adalimumab (the active ingredient in Yuflyma) have caused allergic reactions. Although rare, some reactions can be life threatening (e.g., anaphylaxis). If you experience rash, trouble breathing, or swelling in your face, lips, tongue, or throat, get medical help right away.

                    risk-warning

                    Nervous system effects

                    • Risk factors: Currently have or recently developed a nervous system condition

                      Although rare, people taking medications like Yuflyma (adalimumab) have developed conditions that affect the nervous system, such as multiple sclerosis (MS) and Guillain-Barré syndrome. Let your provider know if you currently have nerve problems. They'll want to monitor you closely while you're taking Yuflyma (adalimumab), since it can make them worse. If you notice any vision problems, numbness or tingling, weakness in your arms or legs, or dizziness, contact your provider.

                      risk-warning

                      Low blood cell counts

                      Although rare, some people taking medications like Yuflyma (adalimumab) have had low amounts of blood cells. This can raise your risk for bleeding and lower your body's ability to fight infections. Contact your provider if you develop a fever that doesn't go away, easy bruising, pale skin, or bleeding.

                      risk-warning

                      Heart failure

                      People taking medications like Yuflyma (adalimumab) have had new or worsening cases of heart failure. Talk to your provider if you currently have heart failure. They'll weigh the benefits and risks to determine if Yuflyma (adalimumab) is right for you. Get medical help if you start to have shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, or tiredness or weakness, as these can be signs of heart failure.

                      risk-warning

                      Lupus-like syndrome

                      Rarely, Yuflyma (adalimumab) can cause a condition called lupus-like syndrome. Call your provider if you feel more tired than usual, experience easy bruising or bleeding, or a rash.

                      dosage

                      Yuflyma (adalimumab) dosage forms

                      Typical dosing for Yuflyma (adalimumab)

                      Adults

                      • Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical starting dose is 40 mg injected under the skin every other week.

                      • Crohn's disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week starting Day 29 (2 weeks later).

                      • Plaque psoriasis and uveitis: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg every other week starting 1 week after the first dose.

                      • Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every week OR 80 mg every other week starting Day 29.

                      Children

                      • Juvenile idiopathic arthritis (weight 66 lbs and more): The typical dose is 40 mg injected under the skin every other week.

                      • Crohn's disease (weight 88 lbs and more): The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week.

                      interactions

                      Interactions between Yuflyma (adalimumab) and other drugs

                      Yuflyma (adalimumab) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Yuflyma (adalimumab). Please note that only the generic name of each medication is listed below.

                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      drug-cost

                      How much does Yuflyma (adalimumab) cost?

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                      Yuflyma (brand)
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                      alternatives

                      What are alternatives to Yuflyma (adalimumab)?

                      There are a number of medications that your doctor can prescribe in place of Yuflyma (adalimumab). Compare a few possible alternatives below.
                      Yuflyma (adalimumab)
                      Used for:

                      • Rheumatoid arthritis (RA) - adults only

                      • Juvenile idiopathic arthritis (JIA) - people age 2 and older

                      • Psoriatic arthritis (PsA) - adults only

                      • Ankylosing spondylitis (AS) - adults only

                      • Crohn's disease (CD) - people age 6 and older

                      • Ulcerative colitis (UC) - adults only

                      • Plaque psoriasis - adults only

                      • Hidradenitis suppurativa - adults only

                      • Uveitis - adults only

                      $914.44 Lowest GoodRx priceView Prices
                      Enbrel (etanercept)
                      Used for:

                      • Rheumatoid arthritis (RA)

                      • Plaque psoriasis (PsO) and psoriatic arthritis (PsA)

                      • Ankylosing spondylitis (AS)

                      • Childhood arthritis (polyarticular juvenile idiopathic arthritis, JIA)

                      $7207.48 Lowest GoodRx priceView Prices
                      Humira (adalimumab)
                      Used for:

                      • Rheumatoid arthritis (RA) - adults only

                      • Juvenile idiopathic arthritis (JIA) - people age 2 and older

                      • Psoriatic arthritis (PsA) - adults only

                      • Ankylosing spondylitis (AS) - adults only

                      • Crohn's disease (CD) - people age 6 and older

                      • Ulcerative colitis (UC) - people age 5 and older

                      • Plaque psoriasis - adults only

                      • Hidradenitis suppurativa (HS) - people age 12 and older

                      • Uveitis - people age 2 and older

                      $1113.25 Lowest GoodRx priceView Prices
                      images

                      Yuflyma (adalimumab) images

                      brown - Yuflyma 40mg / 0.4mL Pre-Filled Autoinjector Solution for Injection
                      This medicine is Brown Carton.brown - Yuflyma 40mg / 0.4mL Pre-Filled Autoinjector Solution for Injection

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                      References

                      Best studies we found

                      Celltrion USA, Inc. (2024). YUFLYMA- adalimumab injection [package insert]. DailyMed.

                      Celltrion USA, Inc. (2024). Celltrion USA announces launch of additional doses for YUFLYMA® (adalimumab-aaty) in the U.S.

                      Furst, D. E., et al. (2022). Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomized, double-blind study in rheumatoid arthritis. Rheumatology.

                      View All References (3)

                      Jeremias, S. (2023). FDA approves Celltrion’s Yuflyma, the ninth adalimumab biosimilar. The American Journal of Managed Care.

                      National Eye Institute. (2023). Uveitis.

                      Solhjoo, M., et al. (2023). Drug-induced lupus erythematosus. StatPearls.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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