The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
When used by itself:
- Tiredness (up to 51%)
- Rash (up to 50%)
- Diarrhea (up to 49%)
- Higher liver enzyme levels (up to 46%)
- Itching (up to 45%)
- Anemia (up to 41%)
- Muscle pain (up to 36%)
- Headache (up to 33%)
- Weight loss (up to 32%)
- Nausea (up to 31%)
- Lower white blood cells (up to 29%)
- Changes in blood sugar levels (up to 26%)
- Lower appetite (up to 24%)
- Cough (up to 22%)
Less Common Side Effects
- Vomiting
- Fever
- Joint pain
- Trouble breathing
Yervoy serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious immune-related side effects: rash, diarrhea, trouble breathing, severe stomach pain, chest pain
- Serious reaction during infusion: itching, trouble breathing, fast heart beat, feeling warm or hot
Source: DailyMed
The following Yervoy side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Bloody, black, or tarry stools
indigestion
itching, skin rash
severe stomach pain, cramping, or burning
unusual tiredness or weakness
vomiting
vomiting of material that looks like coffee grounds, severe and continuing
watery or bloody diarrhea
Less common
Blistering, crusting, irritation, itching, or reddening of the skin
bloody or cloudy urine
blurred vision or other changes in vision
burning, dry, or itching eyes
burning, tingling, numbness or pain in the hands, arms, feet, or legs
chills
clay-colored stools
cracked, dry, or scaly skin
dark urine
darkening of the skin
decreased appetite
decreased frequency or amount of urine
difficulty with breathing, chewing, swallowing, or talking
dizziness
double vision
drooping eyelids
drowsiness
eye discharge or excessive tearing
eye pain or sensitivity to light
fainting
headache, possibly severe
hives or welts
loss of appetite
mental depression
muscle weakness
pain, itching, burning, swelling, bleeding, or a lump under the skin where the needle was placed
painful or difficult urination
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
sensation of pins and needles
severe tiredness
sores, ulcers, or white spots on the lips or in the mouth
stabbing pain
stomach tenderness
swelling of the face, feet, or lower legs
swollen glands
unusual bleeding or bruising
unusual weight gain
yellow eyes or skin
Rare
blue or pale skin
chest pain, possibly moving to the left arm, neck, or shoulder
confusion
difficulty with moving
fast heartbeat
general feeling of discomfort or illness
increased thirst
lower back or side pain
muscle pain or stiffness
muscle weakness
pain or burning in the throat
pain, swelling, or redness in the joints
pains in the stomach or side, possibly radiating to the back
skin irritation or rash, including rash that looks like psoriasis
sores, welts, or blisters on the skin
stiff neck or back
Incidence not known
Back, leg, or stomach pains
blistering, peeling, or loosening of the skin
bleeding gums
general body swelling
inability to move the arms and legs
joint or muscle pain
nosebleeds
red irritated eyes
red skin lesions, often with a purple center
throbbing pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



