The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Taken with Velcade (bortezomib) and dexamethasone:
- Low platelet levels (92%)
- Low white blood cell levels (up to 77%)
- Electrolyte changes (up to 61%)
- Tiredness (59%)
- Nausea (50%)
- Reduced appetite (35%)
- Diarrhea (32%)
- Numbness or tingling in the hands or feet (32%)
- Upper respiratory tract infection (29%)
- Weight loss (26%)
- Cataract (22%)
- Vomiting (21%)
Taken with dexamethasone:
- Low platelet levels (74%)
- Tiredness (73%)
- Nausea (72%)
- Low red blood cell levels (59%)
- Reduced appetite (53%)
- Weight loss (47%)
- Diarrhea (44%)
- Vomiting (41%)
- Electrolyte changes (up to 39%)
- Low white blood cell levels (up to 34%)
- Constipation (25%)
- Shortness of breath (24%)
- Upper respiratory tract infection (21%)
Less Common Side Effects
Taken with Velcade (bortezomib) and dexamethasone:
- Fever
- Dizziness
- Blurred vision
Taken with dexamethasone:
- Cough
- Changes in thinking or behavior
- Fever
- High blood sugar
- Dizziness
- Trouble sleeping
- Dehydration
- Pneumonia
- Nosebleed
- Low potassium levels
- Changes in taste
- Blurred vision
- Headache
Xpovio serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe bleeding: bruising that doesn't go away, bleeding that's hard to stop, nosebleeds, blood in urine, black and tarry stool
- Serious infections: fever, weakness, tiredness, sore throat, cough, body aches, muscle aches, chills
- Low sodium level in blood: nausea, vomiting, diarrhea, headache, confusion, muscle weakness or cramps, feeling tired, seizures
- Serious nervous system problems: dizziness, fainting, confusion, hallucinations, difficulty staying awake, passing out, delirium
- Cataracts: double vision, blurred vision, sensitivity to light or glare
Source: DailyMed
The following Xpovio side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Change in vision such as blurry vision, seeing halos around lights, vision loss
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Change in taste
- Constipation
- Diarrhea
- Fatigue
- Loss of appetite with weight loss
- Nausea
- Vomiting
