The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low platelet levels (up to 92%)
- Low blood cell counts (up to 82%)
- Tiredness (up to 73%)
- Nausea (up to 72%)
- Higher blood sugar levels (up to 62%)
- Changes in lab tests, including protein and electrolyte levels (up to 62%)
- Lower appetite (up to 53%)
- Weight loss (up to 47%)
- Diarrhea (up to 44%)
- Vomiting (up to 41%)
- Tingling sensation in the hands and feet (32%)
Less Common Side Effects
- Constipation
- Upper respiratory tract infections
- Trouble breathing
- Cataract
- Fever
- Blurry vision
- Dizziness
- Taste changes
Please note: The side effects reported include those experienced by people who were also taking bortezomib (Velcade) and dexamethasone.
Xpovio serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe bleeding: feeling weak, bruising that doesn't go away, bleeding that's hard to stop, nosebleeds, blood in urine, black and tarry stool
- Serious infections: fever, weakness, tiredness, sore throat, cough, body aches, muscle aches, chills
- Low sodium level in blood: nausea, vomiting, headache, confusion, muscle weakness or cramps, feeling tired, seizures
- Serious nervous system problems: confusion, hallucinations, difficulty staying awake, passing out, delirium
Source: DailyMed
The following Xpovio side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Change in vision such as blurry vision, seeing halos around lights, vision loss
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Low sodium level—muscle weakness, fatigue, dizziness, headache, confusion
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Change in taste
- Constipation
- Diarrhea
- Fatigue
- Loss of appetite with weight loss
- Nausea
- Vomiting
