Vybrique vs. Viagra for ED: How Do These Sildenafil Options Stack Up?
Vybrique and Viagra both contain sildenafil but have unique formulations and other key differences. Learn more about Vybrique versus Viagra with this guide.
Vybrique
Used for Erectile Dysfunction
Used for Erectile Dysfunction
Vybrique (sildenafil) is an oral film used to treat erectile dysfunction (ED) in adults. As a phosphodiesterase-5 (PDE5) inhibitor, it helps with getting and keeping an erection for sex. The film is placed on the tongue, where it dissolves and is swallowed with saliva without water. It's taken as needed, usually about 1 hour before sex, but can be taken 30 minutes to 4 hours before. The most common side effects include headache, flushing, and indigestion.
What is Vybrique (sildenafil)?
What is Vybrique (sildenafil) used for?
- Erectile dysfunction (ED)
How Vybrique (sildenafil) works
Vybrique (sildenafil) is a phosphodiesterase-5 (PDE5) inhibitor. It blocks a protein in your body called PDE5. This allows blood vessels in the penis to relax and increases blood flow when you’re sexually stimulated, helping you get and keep an erection.
When does Vybrique (sildenafil) start working?Time passed since treatment started:
Drug facts
| Common Brands | Vybrique |
|---|---|
| Drug Class | PDE5 inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Vybrique (sildenafil) essentials
Side effects of Vybrique (sildenafil)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (16-28%)
- Flushing (10-19%)
- Indigestion (3-17%)
- Changes in vision (1-11%)
- Stuffy nose (4-9%)
Less Common Side Effects
- Back pain
- Muscle ache
- Dizziness
- Nausea
- Rash
Vybrique (sildenafil) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Prolonged erection: erection lasting more than 4 hours
- Eye problems: sudden loss of vision in one or both eyes
- Hearing problems: sudden decrease or loss of hearing, ringing in the ears, dizziness
When do Vybrique (sildenafil) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Headache
Flushing
Abnormal vision
Low blood pressure
Priapism
Seek immediate medical care if you experience this side effect.
The following Vybrique (sildenafil) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Bladder pain
burning feeling in the chest or stomach
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
cloudy or bloody urine
dizziness
increased frequency of urination
indigestion
pain on urination
stomach upset
tenderness in the stomach area
Rare
Abnormal vision
behavior change similar to drunkenness
bleeding of the eye
blurred vision
bone pain
breast enlargement
chills
cold sweats
confusion
convulsions (seizures)
cool and pale skin
deafness or hearing loss
decrease in amount of urine or the frequency of urination
decreased vision
difficulty in concentrating
dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position
double vision
drowsiness
dryness, redness, scaling, or peeling of the skin
excessive hunger
fainting or faintness
fast, irregular, or pounding heartbeat
feeling of something in the eye
fever or chills
headache (severe or continuing)
increase in the size of the pupil
increased sweating
increased thirst
lower back or side pain
migraine headache
nausea (severe or continuing)
nervousness
nightmares
numbness of the hands
painful, swollen joints
prolonged, painful erection of penis
redness, burning, or swelling of the eyes
redness, itching, or tearing of the eyes
restless sleep
seeing shades of colors differently than before
sensitivity to light
shakiness
skin lesions with swelling
skin paleness
skin ulcers
slurred speech
sudden weakness
swelling of the face, hands, feet, or lower legs
trouble breathing
twitching of the muscles
unusual feeling of burning or stinging of the skin
unusual tiredness or weakness
vision changes
vision loss, temporary
Incidence not known
Blindness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Aches or pains in the muscles
bloody nose
difficult or labored breathing
flushing
headache
pain or tenderness around the eyes and cheekbones
redness of the skin
stomach discomfort following meals
stuffy or runny nose
trouble sleeping
unusually warm skin
Rare
Abdominal or stomach pain
abnormal dreams
clumsiness or unsteadiness
diarrhea or stomach cramps (severe or continuing)
difficulty in swallowing
ear pain
increased amount of saliva
increased skin sensitivity
lack of coordination
loss of bladder control
mental depression
numbness or tingling of the hands, legs, or feet
rectal bleeding
redness or irritation of the tongue
redness, soreness, swelling, or bleeding of the gums
ringing or buzzing in the ears
sensation of motion, usually whirling, either of one's self or of one's surroundings
sexual problems in men (continuing), including failure to experience a sexual orgasm
sleepiness
sores in the mouth and on the lips
tense muscles
trembling and shaking
vomiting
waking to urinate at night
worsening of asthma
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$67.31
GoodRx discount
$44.65
Pros and cons of Vybrique (sildenafil)
Pros
- Oral film that dissolves on your tongue
- Easy to take on the go without water
- Typically works within 30 minutes to an hour
Cons
- Taken as needed
- Common side effects include headache, flushing, and indigestion
- Interacts with several medications
Pharmacist tips for Vybrique (sildenafil)
- Take Vybrique (sildenafil) only as needed, usually about 1 hour before sexual activity. You can take it 30 minutes to 4 hours before sex.
- Take Vybrique (sildenafil) with or without food. A high-fat meal can slow absorption, so the medication might take longer to work.
- Don't take Vybrique (sildenafil) more than once a day. Taking extra doses can raise your risk of side effects.
- Don't take Vybrique (sildenafil) with nitrate medication or Adempas (riociguat). Combining these medications can cause your blood pressure to drop dangerously low.
- Tell your prescriber if you take blood pressure medications before starting Vybrique (sildenafil). Medications such as doxazosin, tamsulosin, and amlodipine can lower your blood pressure further and cause dizziness, lightheadedness, or fainting.
- Stop taking Vybrique (sildenafil) and get medical help right away if you suddenly lose vision in one or both eyes. This can be a sign of a serious eye problem that could become permanent.
- Stop taking Vybrique (sildenafil) and get medical help right away if you suddenly lose your hearing. You might also have ringing in your ears or dizziness.
- Get medical help right away if you have an erection lasting more than 4 hours (priapism) after taking Vybrique (sildenafil). Without quick treatment, a prolonged erection can permanently damage the penis.
- Use condoms while taking Vybrique (sildenafil) to help prevent sexually transmitted infections (STIs). This medication doesn't protect against STIs, including HIV.
- Storage: Keep Vybrique (sildenafil) at room temperature in its sealed foil pouch. Don't open the pouch until you're ready to take your dose.
How to take Vybrique (sildenafil)
- Open the foil pouch only when you’re ready to take your dose. With dry hands, tear along the notch and carefully peel open the pouch.
- Place the film directly on your tongue with dry fingers. Let the film dissolve, then swallow it with your saliva without water or other liquids.
- Don’t cut or chew the film. Take the entire film to make sure you receive the full dose.
Risks and warnings for Vybrique (sildenafil)
Vybrique (sildenafil) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of heart problems in people with heart disease
- Risk factors: History of a heart condition | Recent heart attack or stroke in the past 6 months | High or low blood pressure
Sexual activity can put extra strain on your heart. Because Vybrique (sildenafil) can also lower your blood pressure, it might not be safe if you have certain heart or blood pressure problems. Talk with your prescriber about your heart health before taking this medication.
Vybrique (sildenafil) isn't recommended if you've had a heart attack, stroke, or irregular heart rhythm problem within the past 6 months. It also isn't recommended if you have very low or uncontrolled high blood pressure, heart failure, or coronary artery disease that causes unstable chest pain. Your risk of low blood pressure might also be higher if you have certain conditions that affect blood flow from your heart or your body's ability to control blood pressure.
Prolonged or painful erection (priapism)
- Risk factors: Medical conditions that affect the penis | Sickle cell anemia | Multiple myeloma | Leukemia
Vybrique (sildenafil) can rarely cause an erection that lasts longer than 4 hours. A painful erection lasting longer than 6 hours is called priapism. Without quick treatment, a prolonged erection can permanently damage the penis.
Your risk might be higher if you have a condition that affects the shape of your penis or if you have sickle cell anemia, multiple myeloma, or leukemia. Get emergency medical help right away if your erection lasts more than 4 hours, even if it isn't painful. Don't wait for it to go away on its own.
Vision loss
- Risk factors: History of NAION | "Crowded" optic disc
Sudden vision loss in one or both eyes can be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare eye condition that can cause permanent vision loss. NAION has been reported after using PDE5 inhibitors, but it isn't clear whether Vybrique (sildenafil) directly causes it. Your risk might be higher if you've had NAION before or have a "crowded" optic disc can also raise risk.
Stop taking Vybrique (sildenafil) and get medical help right away if you suddenly lose vision or notice a major change in your eyesight.
Hearing loss
Vybrique (sildenafil) can rarely cause a sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness. These problems have been reported with PDE5 inhibitors, including Vybrique (sildenafil), but it's unclear whether the medications directly cause them.
Stop taking Vybrique (sildenafil) and get medical help right away if your hearing suddenly gets worse or you lose your hearing.
Low blood pressure with other medications
- Risk factors: Taking alpha blockers | Taking medications for high blood pressure or chest pain (angina) | Taking ritonavir
Vybrique (sildenafil) and alpha blockers, such as doxazosin and [tamsulosin], widen blood vessels and lower blood pressure. Taking them together can lower your blood pressure too much, causing dizziness, lightheadedness, or fainting. Other blood pressure medications can also increase this risk.
Tell your prescriber about all the medications you take before starting Vybrique (sildenafil). If you take an alpha blocker, your prescriber might recommend you start at a lower dose to reduce your risk of low blood pressure.
Interactions with other medications
- Risk factors: Taking nitrate medications | Taking blood pressure medications | Taking alpha blockers | Taking certain antifungals or antivirals | Taking other ED medications at the same time
Vybrique (sildenafil) can interact with certain medications and raise your risk of side effects, including dangerously low blood pressure.
Don't take Vybrique (sildenafil) with nitrates, such as nitroglycerin and isosorbide dinitrate, because your blood pressure can drop too low. It also can also interact with blood pressure medications.
Vybrique (sildenafil) also interacts with certain antifungals or antivirals, like ritonavir, which can raise the amount of medication in your body and increase side effects.
Tell your prescriber and pharmacist about all the medications you take or plan to take. They can check for interactions and adjust your medications if needed.
Vybrique (sildenafil) dosage
Typical dosage for Vybrique (sildenafil)
The typical dose is 50 mg placed on your tongue as needed about 1 hour before sex. You can take it anywhere from 30 minutes to 4 hours before sex.
Your prescriber might adjust your dose based on how well it works and whether you have side effects.
Your dose might be lower if you're an older adult, have liver or kidney problems, or take certain medications that interact with Vybrique (sildenafil). The maximum recommended dose is 100 mg.
Don't take Vybrique (sildenafil) more than once a day, regardless of the dose.
Interactions between Vybrique (sildenafil) and other drugs
Vybrique (sildenafil) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Vybrique (sildenafil). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Amprenavir
- Amyl Nitrite
- Atazanavir
- Boceprevir
- Cobicistat
- Darunavir
- Erythrityl Tetranitrate
- Fosamprenavir
- Indinavir
- Isosorbide Dinitrate
- Isosorbide Mononitrate
- Lopinavir
- Molsidomine
- Nelfinavir
- Nitroglycerin
- Nitroprusside
- Pentaerythritol Tetranitrate
- Propatyl Nitrate
- Riociguat
- Ritonavir
- Saquinavir
- Telaprevir
- Tipranavir
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Cannabis
- Ceritinib
- Clarithromycin
- Conivaptan
- Dihydrocodeine
- Duvelisib
- Fluconazole
- Fosnetupitant
- Idelalisib
- Itraconazole
- Ivosidenib
- Larotrectinib
- Lefamulin
- Lorlatinib
- Lumacaftor
- Nefazodone
- Netupitant
- Simeprevir
- Telithromycin
- Voriconazole
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alfuzosin
- Bosentan
- Bunazosin
- Ciprofloxacin
- Delavirdine
- Doxazosin
- Erythromycin
- Etravirine
- Ketoconazole
- Moxisylyte
- Nebivolol
- Prazosin
- Rifapentine
- Silodosin
- Tamsulosin
- Terazosin
- Trimazosin
How much does Vybrique (sildenafil) cost?
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Vybrique (brand)
$44.65
Vybrique (sildenafil) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vybrique (sildenafil) will not be safe for you to take.
- Taking a nitrate medication
- Taking guanylate cyclase (GC) stimulators, such as Adempas (riociguat)
- History of allergic reaction to any sildenafil product
What are alternatives to Vybrique (sildenafil)?
There are a number of medications that your doctor can prescribe in place of Vybrique (sildenafil). Compare a few possible alternatives below.
News about Vybrique (sildenafil)
