As a patient, you play an important role in your treatment for major depressive disorder. You know your wants, needs, concerns, and goals, and you’re the one that needs to feel comfortable taking the medication as prescribed.
It may be helpful to ask plenty of questions when choosing a medication for depression. This can help you determine which one may be right for you based on:
Your symptoms
What side effects you are concerned about
Cost and insurance coverage
How well it may work with your lifestyle
What you’ve tried in the past
Other conditions you have
Other medications or supplements you take
These questions may help you better understand your medication options for depression, according to Jacques Ambrose, MD, MPH, FAPA, Psychiatrist at Columbia University Irving Medical Center:
Is there anything I can’t eat or drink when taking this medication?
Are there any medication interactions I should know?
What time of day should I take it?
How often do I take it?
How do I take it?
What should I do if I miss a dose?
Does it come as a capsule, tablet, or something else?
Is it safe to cut the pill in half?
What are the possible side effects?
How long will it take to notice the effects of the medication?
“If you have any questions about your medication, it's important to re-engage back with your treatment provider,” says Dr. Ambrose. “Your providers are more than happy to address this confusion.”
You may not need to make an appointment with your provider if it’s only one or two questions. Call their office or use their messaging system (if available) for a quick and convenient answer. Depending on the question, you may also be able to ask your pharmacist.

This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. GoodRx provides no warranty for any information. Please seek medical advice before starting, changing or terminating any medical treatment.
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