Vestura is a combined birth control pill that you take by mouth every day. It contains 2 medications: drospirenone (a progestin) and ethinyl estradiol (an estrogen). In addition to being used as a birth control pill to prevent pregnancy, it can also treat premenstrual dysphoric disorder (PMDD) and acne. Each 28-day pack contains 24 active hormone tablets and 4 placebo tablets. Common side effects include nausea, headache, and weight gain.
Vestura is a generic of the brand name Yaz. Other generics that are like Vestura include Nikki and Loryna.
Vestura is a combination of two hormones, drospirenone (a progestin) and ethinyl estradiol (an estrogen). These two hormones work together to prevent pregnancy by:
Stopping ovulation (preventing the release of an egg) and reducing hormone changes linked to ovulation
Thickening cervical mucus to make it harder for sperm to reach an egg
Thinning the uterine lining, making it less likely for a fertilized egg to implant
Vestura works to treat PMDD by balancing hormone levels to reduce symptoms like mood swings, irritability, and bloating.
Vestura also treats acne by lowering testosterone levels. This leads to less oil production and clogged pores.
Source: DailyMed
Taken by mouth once a day
91% effective at preventing pregnancy if used correctly
Also FDA approved to treat acne and PMDD
Raises the risk of serious blood clots
Can cause unpleasant side effects, like headache, nausea, and vomiting
Doesn't protect against sexually transmitted infections (STIs)
Vestura helps prevent pregnancy, but it doesn't protect you against human immunodeficiency virus (HIV), hepatitis, or other sexually transmitted diseases (STIs). Using a condom along with Vestura can help lower your risk of an STI.
You can start Vestura in different ways. Take your first pill either on the first day of your period or on the first Sunday after your period begins. If you choose the Sunday start, use non-hormonal back-up birth control (like condoms) for the first week, unless your period started on that Sunday.
Take Vestura at the same time every day, in the order directed on the package. Setting an alarm can help you remember, since missing a dose raises the chance of pregnancy.
When you finish a pack of Vestura, start a new pack the next day without skipping days. This keeps hormone levels steady to prevent pregnancy.
If you missed one active Vestura tablet, take it as soon as possible, then take your next pill at the usual time. This might mean taking two pills in one day. If you miss more than one pill, check the instructions on your pack or call your gynecologist for guidance. You might also need to use a back-up birth control for a week.
If you throw up within 3 to 4 hours after taking Vestura, it counts as a missed dose. Follow the missed dose instructions in your package insert or ask your pharmacist or prescriber.
If you have severe vomiting or diarrhea, Vestura might not be absorbed well, making it less effective. Use a back-up birth control method until you can check with your prescriber.
Vestura can interact with many medications. Tell your healthcare team about all prescription, over-the-counter, and supplement products you take before starting this medication.
Get medical help right away if you notice signs of a blood clot, including trouble breathing, leg pain that won't go away, or sudden, severe headache. Though rare, taking combined birth control pills, including Vestura, can raise the risk of blood clots.
You should get your period within 3 days of taking the last active pill. If you don’t get a period, especially if you’ve missed doses of Vestura, talk to your prescriber to rule out pregnancy.
Vestura isn't recommended during breastfeeding since it might lower the amount and quality of breast milk. If you're breastfeeding, ask your prescriber about alternative birth control options.
Vestura can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Over 35 years old who smoke cigarettes
Smoking cigarettes while using Vestura can significantly raise your risk for blood clots. These blood clots can lead to more serious problems, such as heart attack and stroke. The risk is greater if you're over 35 years old and have a history of smoking cigarettes. If you smoke, talk with your gynecologist about safer birth control alternatives.
Risk factors: Age 35 or older and smoke | Recent surgery with a long period of bed rest | Starting Vestura less than a month after childbirth | High blood pressure | | High cholesterol | People identified as obese | Diabetes | Higher dose of estrogen
Vestura can raise the risk of serious blood clots because it contains ethinyl estradiol (an estrogen). Higher estrogen levels can lead to more blood proteins that stimulate clot formation. Some studies also suggest that birth control pills with drospirenone, like Vestura, might have a higher risk of blood clots compared to pills with levonorgestrel or other progestins. These clots can be life-threatening and can form anywhere in your body. Get medical attention right away if you have any signs or symptoms of a blood clot:
Brain (e.g., stroke): weakness or numbness in your arms, legs, or face on one side of the body, trouble speaking, blurry vision, dizziness, loss of balance, trouble walking, or confusion
Eyes (e.g., retinal thrombosis): trouble seeing, bulging eye, or double vision
Heart (e.g., heart attack): chest pain, sweating, nausea, or dizziness
Lungs (e.g., pulmonary embolism or PE): trouble breathing, chest pain, or cough
Legs (e.g., deep vein thrombosis or DVT): cramps, swelling, pain, or muscle tightness
Your risk of blood clots is higher if you're older, smoke cigarettes, or have certain medical conditions. It also increases if you're on bedrest after surgery or have just given birth. Your gynecologist will usually stop Vestura 3-4 weeks before surgery and restart it 2 weeks after to lower your risk. If you recently delivered a baby, you should wait at least 4 weeks after delivery to start this medication, and only if you aren't breastfeeding. Talk with your gynecologist if you have any questions regarding your risk of blood clots.
Risk factors: Kidney, liver, or adrenal gland problems | Taking medications that raise potassium levels | Taking medications that raise Vestura levels
Vestura contains drospirenone, which can cause high levels of potassium in some people. Taking Vestura with medications that raise potassium levels like ACE inhibitors, potassium-sparing diuretics, or potassium supplements can put you more at risk. Your gynecologist might monitor your potassium levels during your first cycle of Vestura and periodically while you're taking it. Contact your health care team if you experience signs of high potassium like nausea, irregular heartbeat, or muscle weakness.
Risk factors: History of breast or cervical cancer | Taking Vestura for a long time
Study results are mixed, but Vestura and other combined hormonal birth control pills might raise your risk for breast and cervical cancer.
Don't take Vestura if you currently have or have had breast cancer because some types of breast cancer grow faster in the presence of estrogen, which is in this medication. Perform breast self-checks regularly at home and get yearly breast exams with your gynecologist to help with early detection. Let them know if you notice any new or abnormal lumps, pain, or swelling in your breasts.
Make sure you follow up with your gynecologist to get proper screenings for cervical cancer. Report any signs of vaginal bleeding or discharge that's not normal.
Risk factors: Taking Vestura for more than 8 years | Certain hepatitis C medications
Don't use Vestura if you have liver problems, such as hepatitis, severe cirrhosis, or liver tumors. Although rare, this medication can raise your risk of benign liver tumors. If you notice signs of liver problems, stop using Vestura and talk to your gynecologist about other birth control options. Signs of liver problems include jaundice (yellowing of the skin or whites of the eyes), fever, tiredness, loss of appetite, or dark urine..
Some studies suggest that Vestura can raise the risk of gallbladder disease since more progestin and estrogen can lead to higher chance of gallstones. Although the risk is low, talk to your gynecologist if you have a history of gallbladder disease before starting this medication.
Risk factors: Older age | Using hormonal contraceptives for a long time | History of high blood pressure
Vestura can raise your blood pressure. The risk is higher if you're older and have been using birth control for a long time. If you have a history of high blood pressure that's well-controlled, your prescriber might monitor you while you use Vestura. If you have concerns, talk with them about the risks and benefits of using this medication.
Risk factors: Prediabetes or diabetes | High triglycerides
Vestura can raise your blood sugar and triglycerides levels. If you have prediabetes or diabetes, your prescriber will likely monitor your blood sugar while you take this medication. High triglycerides can lead to a higher risk of pancreatitis (inflammation of the pancreas). Speak with your gynecologist before starting Vestura if you have a history of high blood sugar or triglycerides. They might suggest a different birth control option or monitor your lab work more closely while you're using this medication.
Let your gynecologist know if you experience new or worsening migraines or headaches while using Vestura. If you develop frequent, severe, or new headaches, you might need to stop the medication.
Risk factors: First 3 months of COCs
People who take Vestura can sometimes experience irregular bleeding and spotting, especially during the first 3 months of taking this medication. Irregular bleeding can vary from slight staining to bleeding similar to a regular period. This problem is often temporary, so continue taking your medication as directed. If your bleeding doesn't stop, becomes heavier, or you miss a period after the initial bleeding, let your gynecologist know. Your gynecologist can perform blood tests to rule out pregnancy or other potential causes for bleeding.
Risk factors: History of depression
If you have a history of depression, your prescriber will monitor you while using Vestura. If your depression gets worse or becomes serious, they might stop the medication. Let your prescriber know if you experience mood changes, sadness, or loss of interest in activities while taking this medication.
Risk factors: History of hereditary angioedema | History of chloasma gravidarum
If you have certain conditions, such as hereditary angioedema or chloasma (a skin condition that causes dark patches on the face), talk to your prescriber before taking Vestura because it might worsen your symptoms. If you have a history of chloasma, limit exposure to the sun or UV light while taking Vestura.
Vestura comes in a 28-day pack, which contains 24 active hormone tablets and 4 placebo tablets. Each active tablet contains 3 mg drospirenone and 20 mcg ethinyl estradiol. Placebo tablets don't contain any active medication.
Follow your prescriber's instructions on how to take this medication. The tablets must be taken in order as shown on the packaging.
The typical dose is 1 active tablet by mouth daily for 24 days, followed by 1 placebo tablet daily for the remaining 4 days.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Kidney or adrenal gland problems
History of blood clots, stroke, or heart attack
Over 35 years old who smoke
Currently have or have had a blood clot
Blood clotting condition
Certain heart rhythm problems, like atrial fibrillation (AFib)
High blood pressure that's not under control
Diabetes with high blood pressure or organ damage
Any migraine headaches for those over 35 years old
Have a body mass index (BMI) at or greater than 30 kg/m²
Liver problems or liver disease
Unexplained vaginal bleeding that hasn't been diagnosed
Currently have or have had breast cancer
Take hepatitis C combination medications containing ombitasvir/paritaprevir/ritonavir
By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.
DailyMed. (n.d.). Vestura (drospirenone and ethinyl estradiol) kit.
Etminan, M., et al. (2011). Oral contraceptives and the risk of gallbladder disease: A comparative safety study. Canadian Medical Association Journal.
Gronich, N., et al. (2011). Higher risk of venous thrombosis associated with drospirenone-containing oral contraceptives: A population-based cohort study. Canadian Medical Association Journal.
International Agency for Research on Cancer. (2012). Combined estrogen-progestogen contraceptives. Pharmaceuticals.
Latwal, B., et al. (2020). Authorized generics vs. branded generics: A perspective. Journal of Generic Medicines.
Mu, E., et al. (2022). Hormonal contraception and mood disorders. Australian Prescriber.
Teva Pharmaceuticals, Inc. (2024). Vestura- drospirenone and ethinyl estradiol kit [package insert]. DailyMed.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.