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Vestura

drospirenone / ethinyl estradiol

Vestura is a combined birth control pill that you take by mouth every day. It contains 2 medications: drospirenone (a progestin) and ethinyl estradiol (an estrogen). In addition to being used as a birth control pill to prevent pregnancy, it can also treat premenstrual dysphoric disorder (PMDD) and acne. Each 28-day pack contains 24 active hormone tablets and 4 placebo tablets. Common side effects include nausea, headache, and weight gain.

Vestura is a generic of the brand name Yaz. Other generics that are like Vestura include Nikki and Loryna.

Last reviewed on February 20, 2025
basics-icon

What is Vestura?

What is Vestura used for?

How Vestura works

Vestura is a combination of two hormones, drospirenone (a progestin) and ethinyl estradiol (an estrogen). These two hormones work together to prevent pregnancy by:

  • Stopping ovulation (preventing the release of an egg) and reducing hormone changes linked to ovulation

  • Thickening cervical mucus to make it harder for sperm to reach an egg

  • Thinning the uterine lining, making it less likely for a fertilized egg to implant

Vestura works to treat PMDD by balancing hormone levels to reduce symptoms like mood swings, irritability, and bloating.

Vestura also treats acne by lowering testosterone levels. This leads to less oil production and clogged pores.

When does Vestura start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsVestura
Drug ClassEstrogen / Progestin combined contraceptive
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Vestura?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Pregnancy prevention and acne:
  • Headache or migraine (7%)
  • Irregular menstrual bleeding (5%)
  • Nausea or vomiting (4%)
  • Breast pain or tenderness (4%)
PMDD:
  • Irregular menstrual bleeding (25%)
  • Nausea (16%)
  • Headache (13%)
  • Breast tenderness (11%)
  • Tiredness (4%)

Other Side Effects

  • Mood changes
  • Irritability
  • Lower sex drive
  • Weight gain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Heart attack: chest pain, belly discomfort, sweating, nausea, dizziness
  • Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
  • Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, pain, muscle tightness
  • Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
  • Liver or gallbladder problems: yellowing of the skin or the whites of the eyes, tiredness, pain in the right upper stomach, dark urine
  • High potassium levels: muscle weakness, nausea, irregular heart beat
When do Vestura possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Irregular menstrual bleeding
Nausea
Headache
Breast tenderness
Mood changes
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

pros-and-cons

Pros and cons of Vestura

thumbs-up

Pros

Taken by mouth once a day

91% effective at preventing pregnancy if used correctly

Also FDA approved to treat acne and PMDD

thumbs-down

Cons

Raises the risk of serious blood clots

Can cause unpleasant side effects, like headache, nausea, and vomiting

pharmacist-tips

Pharmacist tips for Vestura

pharmacist
  • You can start Vestura in different ways. Take your first pill either on the first day of your period or on the first Sunday after your period begins. If you choose the Sunday start, use non-hormonal back-up birth control (like condoms) for the first week, unless your period started on that Sunday.

    • Take Vestura at the same time every day, in the order directed on the package. Setting an alarm can help you remember, since missing a dose raises the chance of pregnancy.

      • When you finish a pack of Vestura, start a new pack the next day without skipping days. This keeps hormone levels steady to prevent pregnancy.

        • If you missed one active Vestura tablet, take it as soon as possible, then take your next pill at the usual time. This might mean taking two pills in one day. If you miss more than one pill, check the instructions on your pack or call your gynecologist for guidance. You might also need to use a back-up birth control for a week.

          • If you throw up within 3 to 4 hours after taking Vestura, it counts as a missed dose. Follow the missed dose instructions in your package insert or ask your pharmacist or prescriber.

            • If you have severe vomiting or diarrhea, Vestura might not be absorbed well, making it less effective. Use a back-up birth control method until you can check with your prescriber.

              • Vestura can interact with many medications. Tell your healthcare team about all prescription, over-the-counter, and supplement products you take before starting this medication.

                • Get medical help right away if you notice signs of a blood clot, including trouble breathing, leg pain that won't go away, or sudden, severe headache. Though rare, taking combined birth control pills, including Vestura, can raise the risk of blood clots.

                  • You should get your period within 3 days of taking the last active pill. If you don’t get a period, especially if you’ve missed doses of Vestura, talk to your prescriber to rule out pregnancy.

                    • Vestura isn't recommended during breastfeeding since it might lower the amount and quality of breast milk. If you're breastfeeding, ask your prescriber about alternative birth control options.

                      faqs

                      Frequently asked questions about Vestura

                      Is Vestura the same as Yaz?
                      Vestura is a branded generic of Yaz. Both contain the same doses of the same hormones (drospirenone and ethinyl estradiol) and work to prevent pregnancy and treat other conditions. The tablets might look different, but they should work the same.
                      Does Vestura cause weight gain?
                      Some people taking combination birth control pills, including Vestura, have reported weight gain, but it's unclear if birth control is the cause. In most cases, weight gain is due to water retention (bloating), not body fat. If you're concerned about weight changes, talk to your OB-GYN.
                      Is Vestura a combination pill?
                      Yes, Vestura is a combined birth control pill, meaning it contains both estrogen and progestin. Each active tablet has two hormones, drospirenone and ethinyl estradiol.
                      Was Vestura discontinued?
                      Vestura has been made by different manufacturers over the years, though some no longer make it. It's currently available from Teva Pharmaceuticals, Inc.
                      Does Vestura cause anxiety as a side effect?
                      Anxiety wasn't a commonly reported side effect in clinical studies. While some people have reported anxiety with other hormonal birth control methods, more research is needed to confirm a direct link. Anxiety is also a common symptom of PMDD, which Vestura is used to treat. If you feel more anxious after starting this medication, talk to your prescriber.
                      Does Vestura stop your period?
                      Vestura can stop your period, and changes in bleeding, including skipped periods, are common with birth control pills. But a missed period could also mean pregnancy. If you miss two periods in a row or miss one after not taking your pills correctly, take a pregnancy test or check in with your prescriber about next steps.
                      Is Vestura a low-dose birth control?
                      Yes. Low-dose birth control is a combination oral contraceptive (COC) that contains 20 mcg or less of ethinyl estradiol (estrogen). Vestura is low-dose because its active pills contain 20 mcg of ethinyl estradiol.
                      What are some common side effects of Vestura?
                      During clinical studies of Vestura, common side effects that people reported include irregular menstrual bleeding, nausea, vomiting, headache, migraine, breast pain, and breast tenderness. These side effects are typically mild and get better with time. If any side effects become bothersome or don’t go away, talk to your prescriber.
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                      warings-icon

                      What are the risks and warnings for Vestura?

                      Vestura can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                      risk-warning

                      Cigarette smoking and serious heart problems

                      • Risk factors: Over 35 years old who smoke cigarettes

                        Smoking cigarettes while using Vestura can significantly raise your risk for blood clots. These blood clots can lead to more serious problems, such as heart attack and stroke. The risk is greater if you're over 35 years old and have a history of smoking cigarettes. If you smoke, talk with your gynecologist about safer birth control alternatives.

                        risk-warning

                        Risk of blood clot

                        • Risk factors: Age 35 or older and smoke | Recent surgery with a long period of bed rest | Starting Vestura less than a month after childbirth | High blood pressure | | High cholesterol | People identified as obese | Diabetes | Higher dose of estrogen

                          Vestura can raise the risk of serious blood clots because it contains ethinyl estradiol (an estrogen). Higher estrogen levels can lead to more blood proteins that stimulate clot formation. Some studies also suggest that birth control pills with drospirenone, like Vestura, might have a higher risk of blood clots compared to pills with levonorgestrel or other progestins. These clots can be life-threatening and can form anywhere in your body. Get medical attention right away if you have any signs or symptoms of a blood clot:

                          • Brain (e.g., stroke): weakness or numbness in your arms, legs, or face on one side of the body, trouble speaking, blurry vision, dizziness, loss of balance, trouble walking, or confusion

                            • Eyes (e.g., retinal thrombosis): trouble seeing, bulging eye, or double vision

                              • Heart (e.g., heart attack): chest pain, sweating, nausea, or dizziness

                                • Lungs (e.g., pulmonary embolism or PE): trouble breathing, chest pain, or cough

                                  • Legs (e.g., deep vein thrombosis or DVT): cramps, swelling, pain, or muscle tightness

                                    Your risk of blood clots is higher if you're older, smoke cigarettes, or have certain medical conditions. It also increases if you're on bedrest after surgery or have just given birth. Your gynecologist will usually stop Vestura 3-4 weeks before surgery and restart it 2 weeks after to lower your risk. If you recently delivered a baby, you should wait at least 4 weeks after delivery to start this medication, and only if you aren't breastfeeding. Talk with your gynecologist if you have any questions regarding your risk of blood clots.

                                    risk-warning

                                    High potassium

                                    • Risk factors: Kidney, liver, or adrenal gland problems | Taking medications that raise potassium levels | Taking medications that raise Vestura levels

                                      Vestura contains drospirenone, which can cause high levels of potassium in some people. Taking Vestura with medications that raise potassium levels like ACE inhibitors, potassium-sparing diuretics, or potassium supplements can put you more at risk. Your gynecologist might monitor your potassium levels during your first cycle of Vestura and periodically while you're taking it. Contact your health care team if you experience signs of high potassium like nausea, irregular heartbeat, or muscle weakness.

                                      risk-warning

                                      Breast and cervical cancer

                                      • Risk factors: History of breast or cervical cancer | Taking Vestura for a long time

                                        Study results are mixed, but Vestura and other combined hormonal birth control pills might raise your risk for breast and cervical cancer.

                                        Don't take Vestura if you currently have or have had breast cancer because some types of breast cancer grow faster in the presence of estrogen, which is in this medication. Perform breast self-checks regularly at home and get yearly breast exams with your gynecologist to help with early detection. Let them know if you notice any new or abnormal lumps, pain, or swelling in your breasts.

                                        Make sure you follow up with your gynecologist to get proper screenings for cervical cancer. Report any signs of vaginal bleeding or discharge that's not normal.

                                        risk-warning

                                        Liver problems

                                        • Risk factors: Taking Vestura for more than 8 years | Certain hepatitis C medications

                                          Don't use Vestura if you have liver problems, such as hepatitis, severe cirrhosis, or liver tumors. Although rare, this medication can raise your risk of benign liver tumors. If you notice signs of liver problems, stop using Vestura and talk to your gynecologist about other birth control options. Signs of liver problems include jaundice (yellowing of the skin or whites of the eyes), fever, tiredness, loss of appetite, or dark urine..

                                          risk-warning

                                          Gallbladder problems

                                          Some studies suggest that Vestura can raise the risk of gallbladder disease since more progestin and estrogen can lead to higher chance of gallstones. Although the risk is low, talk to your gynecologist if you have a history of gallbladder disease before starting this medication.

                                          risk-warning

                                          High blood pressure

                                          • Risk factors: Older age | Using hormonal contraceptives for a long time | History of high blood pressure

                                            Vestura can raise your blood pressure. The risk is higher if you're older and have been using birth control for a long time. If you have a history of high blood pressure that's well-controlled, your prescriber might monitor you while you use Vestura. If you have concerns, talk with them about the risks and benefits of using this medication.

                                            risk-warning

                                            High blood sugar and triglycerides

                                            • Risk factors: Prediabetes or diabetes | High triglycerides

                                              Vestura can raise your blood sugar and triglycerides levels. If you have prediabetes or diabetes, your prescriber will likely monitor your blood sugar while you take this medication. High triglycerides can lead to a higher risk of pancreatitis (inflammation of the pancreas). Speak with your gynecologist before starting Vestura if you have a history of high blood sugar or triglycerides. They might suggest a different birth control option or monitor your lab work more closely while you're using this medication.

                                              risk-warning

                                              Headache

                                              Let your gynecologist know if you experience new or worsening migraines or headaches while using Vestura. If you develop frequent, severe, or new headaches, you might need to stop the medication.

                                              risk-warning

                                              Irregular bleeding

                                              • Risk factors: First 3 months of COCs

                                                People who take Vestura can sometimes experience irregular bleeding and spotting, especially during the first 3 months of taking this medication. Irregular bleeding can vary from slight staining to bleeding similar to a regular period. This problem is often temporary, so continue taking your medication as directed. If your bleeding doesn't stop, becomes heavier, or you miss a period after the initial bleeding, let your gynecologist know. Your gynecologist can perform blood tests to rule out pregnancy or other potential causes for bleeding.

                                                risk-warning

                                                Depression

                                                • Risk factors: History of depression

                                                  If you have a history of depression, your prescriber will monitor you while using Vestura. If your depression gets worse or becomes serious, they might stop the medication. Let your prescriber know if you experience mood changes, sadness, or loss of interest in activities while taking this medication.

                                                  risk-warning

                                                  Worsening of other health conditions

                                                  • Risk factors: History of hereditary angioedema | History of chloasma gravidarum

                                                    If you have certain conditions, such as hereditary angioedema or chloasma (a skin condition that causes dark patches on the face), talk to your prescriber before taking Vestura because it might worsen your symptoms. If you have a history of chloasma, limit exposure to the sun or UV light while taking Vestura.

                                                    dosage

                                                    Vestura dosage forms

                                                    Typical dosing for Vestura

                                                    Vestura comes in a 28-day pack, which contains 24 active hormone tablets and 4 placebo tablets. Each active tablet contains 3 mg drospirenone and 20 mcg ethinyl estradiol. Placebo tablets don't contain any active medication.

                                                    Follow your prescriber's instructions on how to take this medication. The tablets must be taken in order as shown on the packaging.

                                                    The typical dose is 1 active tablet by mouth daily for 24 days, followed by 1 placebo tablet daily for the remaining 4 days.

                                                    interactions

                                                    Interactions between Vestura and other drugs

                                                    Vestura may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Vestura. Please note that only the generic name of each medication is listed below.

                                                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                                                    How much does Vestura cost?

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                                                    contraindications-icon

                                                    Vestura contraindications

                                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vestura will not be safe for you to take.
                                                    alternatives

                                                    What are alternatives to Vestura?

                                                    There are a number of medications that your doctor can prescribe in place of Vestura. Compare a few possible alternatives below.
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                                                    References

                                                    Best studies we found
                                                    View All References (4)

                                                    International Agency for Research on Cancer. (2012). Combined estrogen-progestogen contraceptives. Pharmaceuticals.

                                                    Latwal, B., et al. (2020). Authorized generics vs. branded generics: A perspective. Journal of Generic Medicines.

                                                    Mu, E., et al. (2022). Hormonal contraception and mood disorders. Australian Prescriber.

                                                    Teva Pharmaceuticals, Inc. (2024). Vestura- drospirenone and ethinyl estradiol kit [package insert]. DailyMed.

                                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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