The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Feeling irritable (up to 62%)
- Sleepiness (up to 56%)
- Pain at the injection site (up to 53%)
- Crying (up to 52%)
- Redness at the injection site (up to 32%)
- Fever (up to 29%)
- Feeling less hungry (up to 29%)
- Swelling at the injection site (up to 23%)
- Vomiting (up to 13%)
Less Common Side Effects
- Rash
- Swelling of the limb
Note: These side effects were reported in clinical trials with children up to 6 months old who received Prevnar 13 and RotaTeq at the same time as Vaxelis.
Vaxelis serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: hives, rash, itching, nausea, flushing, dizziness, trouble breathing, chest pain
Source: DailyMed
The following Vaxelis side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

