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Vancomycin

Vancomycin Side Effects

Ally Tsai, PharmDKristianne Hannemann, PharmD
Reviewed by Ally Tsai, PharmD, Kristianne Hannemann, PharmD
Last reviewed on January 14, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain and redness at the injection site

Less Common Side Effects

  • Fever
  • Chills
  • Dizziness

Vancomycin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe infusion reaction: itchy skin; hives; redness in the face, neck, or upper body; wheezing; trouble breathing; body aches; dizziness; weakness; chest pain; muscle pain
  • Sudden kidney injury: feeling sick or weak; urinating less than usual; blood in urine; confusion; swelling in the legs, ankles, or feet
  • Hearing problems: ringing in the ears, hearing loss, dizziness, feeling like the room is spinning
  • Severe skin reaction: rash, blistering, skin peeling, hives, painful sores in your mouth or around your eyes, fever, trouble breathing, swollen lymph nodes
  • Severe diarrhea: watery diarrhea, bloody stools, fever, belly pain, loss of appetite, nausea

Source: DailyMed

The following Vancomycin side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Hearing loss, ringing in ears
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe diarrhea, fever
  • Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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