The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Upper respiratory tract infection (8-10%)
- Urinary tract infection (10%)
- Common cold (6-8%)
- Diarrhea (2-7%)
- Constipation (5-6%)
- Headache (5%)
- Stomach flu (gastroenteritis) (3-6%)
Less Common Side Effects
- Low blood sugar
- Frequent urination
- Joint pain
- Genital yeast infections
- Nausea or vomiting
- Thirst
- Stomach gas
- Indigestion
Trijardy XR serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Lactic acidosis (buildup of lactic acid): unusual muscle pain, difficulty breathing, unusual sleepiness, stomach pain, feeling cold in hands or feet, low blood pressure, slow heart rate, very weak or tired
- Pancreatitis (inflammation of the pancreas): severe stomach pain that doesn't go away, pain that starts from the stomach and wraps to the back, sometimes vomiting
- Ketoacidosis (buildup of ketones): dehydration, nausea, vomiting, stomach pain, tiredness, shortness of breath
- Heart failure: shortness of breath, sudden fast weight gain, swelling of the feet
- Kidney problems: low urine production, swelling in the legs, nausea, tiredness, shortness of breath
- Fournier's gangrene (flesh-eating bacterial infection of the genitals): fever or discomfort along with pain, tenderness, redness, or swelling in the genital area
- Serious skin reactions: fluid-filled blisters, top layer of your skin looks like it's breaking down
- Serious allergic reactions: rash, hives, swelling of the face, lips, tongue, and throat that causes difficulty breathing or difficulty swallowing
Source: DailyMed
The following Trijardy XR side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
- Diabetic ketoacidosis (DKA)—increased thirst or amount of urine, dry mouth, fatigue, fruity odor to breath, trouble breathing, stomach pain, nausea, vomiting
- Genital yeast infection—redness, swelling, pain, or itchiness, odor, thick or lumpy discharge
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- High lactic acid level—muscle pain or cramps, stomach pain, trouble breathing, general discomfort and fatigue
- Infection or redness, swelling, tenderness, or pain in the genitals, or area from the genitals to the back of the rectum
- Low vitamin B12 level—pain, tingling, or numbness in the hands or feet, muscle weakness, dizziness, confusion, trouble concentrating
- Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Severe joint pain
- Urinary tract infection (UTI)—burning when passing urine, passing frequent small amounts of urine, bloody or cloudy urine, pain in the lower back or sides
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Cough
- Diarrhea
- Headache
- Runny or stuffy nose
- Sore throat
