Skip to main content
Methotrexate

Methotrexate Dosage

Allison Baxley, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Allison Baxley, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on December 6, 2023

The average cost for 24 tablets of 2.5mg of Methotrexate is $13.46 with a free GoodRx coupon. This is 53.20% off the average retail price of $28.76.

tabletTablet

Dosage

Quantity

Price as low as

Price per unit

2.5mg

24 tablets

$13.46

$0.56

vialVial

Dosage

Quantity

Price as low as

Price per unit

2ml of 25mg/ml

2 vials

$12.10

$6.05

10ml of 25mg/ml

1 vial

$17.69

$17.69

1g

12 vials

$235.21

$19.60

4ml of 25mg/ml

1 vial

$17.23

$17.23

Typical dosage for Methotrexate

The dose of Methotrexate varies depending on what condition you’re taking the medication for. Sometimes, the dose depends on your body size or body surface area (BSA) in m2 units.

The manufacturer dosages are listed below, but your dose might be different depending on the specific guidelines that your provider uses. Your provider might adjust the dose based on your response to Methotrexate.

Cancer

  • Acute lymphoblastic leukemia: The typical starting dose is 20 mg/m2 by mouth once a week. Methotrexate is taken together with other chemotherapy.
  • Mycosis fungoides: When taken by itself, the typical dose of Methotrexate is 25 mg to 75 mg by mouth once a week. When it’s taken with other chemotherapy, the typical dose of Methotrexate is 10 mg/m2 by mouth twice a week.
  • Non-Hodgkin lymphoma: The typical dose is 2.5 mg by mouth 2 to 4 times per week, taken together with chemotherapy.

Non-cancer conditions

  • Rheumatoid arthritis: The typical starting dose is 7.5 mg by mouth once a week.
  • Polyarticular juvenile idiopathic arthritis: The typical starting dose is 10 mg/m2 by mouth once per week.
  • Psoriasis: The typical dose is 10 mg to 25 mg by mouth once a week.
  • For non-cancer conditions, Methotrexate is commonly taken with folic acid supplements to help lower the risk for side effects.

Was this page helpful?