The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Lower hemoglobin levels (60%)
- Changes in electrolyte levels (up to 39%)
- Tiredness (39%)
- High white blood cell count (38%)
- Joint pain (36%)
- Diarrhea (34%)
- Trouble breathing (33%)
- Swelling (32%)
- Nausea (31%)
- Mouth sores (28%)
- Elevated liver enzyme levels (up to 27%)
- Changes in electrocardiogram (EKG) results (26%)
- Rash (26%)
- Fever (23%)
- Higher creatinine levels (23%)
- Cough (22%)
- Constipation (20%)
Less Common Side Effects
- Lower appetite
- Vomiting
- Chest pain
- Stomach pain
- Muscle pain
- Headache
- Numbness and tingling
- Low blood pressure
- Differentiation syndrome
Note: Side effect data were reported by people with relapsed or refractory AML. Side effects might differ for people with MDS or bile duct cancer.
Tibsovo serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Differentiation syndrome (for people with AML or MDS only): fever, sudden weight gain, trouble breathing, chest pain, swelling in legs
- Abnormal heart rhythm: irregular heartbeat, blurry vision, lightheadedness, fainting, loss of consciousness
Source: DailyMed
The following Tibsovo side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Fever, cough, dizziness, feeling faint or lightheaded, shortness of breath, bone pain, sudden weight gain, swelling of the ankles, hands, or feet, which may be signs of differentiation syndrome
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- High white blood cell level—fever, fatigue, trouble breathing, night sweats, change in vision, weight loss
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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