Rasonque
Rasonque (daraxonrasib) is used to treat adults with metastatic pancreatic cancer. It's an option for people who've already received another treatment or can't receive certain combination treatments. Rasonque (daraxonrasib) works as a RAS inhibitor that helps slow or stop cancer growth. It comes as tablets taken by mouth once a day. Common side effects include rash, diarrhea, mouth sores, and nausea.
What is Rasonque (daraxonrasib)?
What is Rasonque (daraxonrasib) used for?
How Rasonque (daraxonrasib) works
Rasonque (daraxonrasib) is a type of targeted therapy called a RAS inhibitor. RAS proteins play a role in driving tumor growth in most people with pancreatic cancer.
Rasonque (daraxonrasib) targets the active form of certain RAS proteins and blocks signals that tell the cancer to grow. This help slow the growth and spread of pancreatic cancer.
Drug facts
| Common Brands | Rasonque |
|---|---|
| Drug Class | RAS inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Rasonque (daraxonrasib)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Rash (87%)
- Lower albumin levels (71%)
- Diarrhea (67%)
- Lower calcium levels (64%)
- Mouth sores (56%)
- Nausea (52%)
- Lower hemoglobin levels (52%)
- Higher liver enzyme levels (up to 51%)
- Lower white blood cell count (up to 49%)
- Tiredness (47%)
- Lower platelet count (45%)
- Vomiting (42%)
- Lower sodium levels (36%)
- Lower magnesium levels (34%)
- Stomach pain (27%)
- Swelling (25%)
Less Common Side Effects
- Lower appetite
- Constipation
- Muscle or joint pain
- Fever
- Bleeding
- Dry skin
- Itching
- Numbness or tingling in the hands or feet
- Infection around the nails (paronychia)
- Higher creatinine levels
- Lower potassium levels
Rasonque (daraxonrasib) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe skin reaction: severe or worsening rash, severe itching, painful or cracked skin, painful swelling around the nails
- Severe mouth sores: severe mouth pain or sores that make it hard to eat, talk, or swallow
- Severe diarrhea: severe or worsening watery stools, weakness, signs of dehydration
- Stomach or intestinal damage: severe or lasting stomach pain, bloody or black stools, fever, chills, vomiting blood
- Lung inflammation: new or worsening cough, shortness of breath, trouble breathing, wheezing
The following Rasonque (daraxonrasib) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Diarrhea
- Dry cough, shortness of breath or trouble breathing
- Pain, redness, or swelling with sores inside the mouth or throat
- Skin rash, itching, dry or cracked skin, redness, swelling, warmth, or pain around the nail
- Stomach pain that is severe, does not go away, or gets worse
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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Pros and cons of Rasonque (daraxonrasib)
Pros
- Taken by mouth once a day
- Targeted treatment that blocks signals that help pancreatic cancer grow
Cons
- Often causes rash, mouth sores, and diarrhea
- Interacts with some medications, including certain antifungals and antibiotics
Pharmacist tips for Rasonque (daraxonrasib)
- Take Rasonque (daraxonrasib) once a day, around the same time every day. You can take it with or without food. Following the same routine each day can help you remember to take the medication.
- Swallow Rasonque (daraxonrasib) tablets whole. Don’t chew, crush, or split the tablets. This can affect how the medication is released.
- If you miss a dose of Rasonque (daraxonrasib), follow the 4-hour rule. Take it as soon as you remember if it's within 4 hours of your usual time. If more than 4 hours have passed, skip it and take your next dose at the usual time. Don’t take two doses at once to make up for a missed dose.
- If you vomit after taking Rasonque (daraxonrasib), don’t take another dose since it can raise your risk of side effects. Take your next dose at the usual time.
- Follow your oncology care team's skin care plan to help prevent serious skin reactions from Rasonque (daraxonrasib). They might recommend a topical steroid for your face and chest and a moisturizer. They might also give you an antibiotic, such as doxycycline or minocycline.
- Protect your skin from the sun while taking Rasonque (daraxonrasib) by limiting sun exposure. Also use sunscreen and wear clothing that protects your skin from the sun. This can help keep skin reactions from becoming more severe.
- Tell your oncology care team if you have mouth sores while taking Rasonque (daraxonrasib). This can be painful and make it hard to eat, talk, or swallow. Your care team can find ways to help, like a medicated mouthwash or foods to avoid.
- Tell your oncology care team right away if you have diarrhea while taking Rasonque (daraxonrasib). Diarrhea is common, but it can also become severe and lead to dehydration. Your care team might recommend medication for diarrhea. Be sure to drink plenty of fluids to stay hydrated if diarrhea happens.
- Tell your oncologist and pharmacist about all the medications and supplements you take. Some can change Rasonque (daraxonrasib) levels in the body. This can either raise the risk of side effects or make the cancer medication work less well. Your care team can check for interactions and adjust your medications if needed. sSme might need to be taken several hours apart from Rasonque (daraxonrasib).
- If you or your partner can become pregnant: Use reliable birth control and condoms while taking Rasonque (daraxonrasib) and for 1 week after your last dose. This medication can harm an unborn baby. Let your oncologist know if you or your partner becomes pregnant during treatment.
- If you're breastfeeding or plan to breastfeed: Don’t breastfeed while taking Rasonque (daraxonrasib) and for 1 week after your last dose. We don't know if the medication can pass into breast milk. But it could cause serious side effects in a breastfed baby if it does. Talk to your oncologist or a lactation specialist about safe feeding options.
Risks and warnings for Rasonque (daraxonrasib)
Rasonque (daraxonrasib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious skin reactions and nail infections
Rasonque (daraxonrasib) can cause skin reactions that can sometimes be severe. These can include rash, itching, dry or cracked skin, and infections around the nails (paronychia). Skin reactions can start within the first couple weeks of treatment. But they can also happen months later. With management, the reaction often gets better within a few weeks but can take longer in certain cases.
Before you start Rasonque (daraxonrasib), your oncology care team will recommend a few things to help prevent severe skin reactions. This can include a topical steroid, moisturizer, and sunscreen. Try to limit your time in the sun and follow their skin care instructions.
Tell your oncologist right away if you notice a new or worsening rash, severe itching, cracked skin, or painful swelling around your nails. Depending on how severe it is, they might pause Rasonque (daraxonrasib), lower your dose, or stop treatment.
Mouth sores
Rasonque (daraxonrasib) can cause mouth sores and inflammation in the mouth. It can cause pain, redness, swelling, or sores that make eating, talking, or swallowing hard. In studies, this has happened within the first few weeks of treatment. But they can also happen months later. Most times, mouth sores can improve within 2 weeks but can also sometimes take longer.
Tell your oncologist right away about new or worsening mouth pain, redness, swelling, or sores. Also tell them if this makes it hard to eat, talk, or swallow. Your oncologist might prescribe a medicated mouthwash to help manage this side effect. Depending on how severe it is, they might pause Rasonque (daraxonrasib), lower your dose, or stop the medication.
Diarrhea
Rasonque (daraxonrasib) can cause diarrhea. This can start within days of beginning treatment but can also happen months later. Usually, it gets better within days or weeks.
Before starting Rasonque (daraxonrasib), talk to your oncologist about what to do if diarrhea happens. They might recommend an antidiarrheal medication. Also, it's a good idea to drink plenty of fluids to stay hydrated.
If diarrhea starts becoming hard to tolerate, tell your oncologist right away. Depending on how severe it is, they might decide to pause Rasonque (daraxonrasib), lower your dose, or stop the medication altogether.
Stomach or intestinal damage
Rarely, Rasonque (daraxonrasib) can cause a hole or tear in the stomach or intestines. This is called gastrointestinal perforation. This can be serious and can happen weeks or months after starting treatment.
Get medical help right away if you have severe or long-lasting stomach pain or tenderness. Also get medical help if you notice bloody or black stools, fever, chills, or blood in your vomit. Your oncologist will likely pause Rasonque (daraxonrasib) while they check for the cause. Don’t restart it unless they tell you to.
Lung inflammation
Rarely, Rasonque (daraxonrasib) can cause lung inflammation. This can include interstitial lung disease or pneumonitis. This can be serious and might happen months after starting treatment.
Tell your oncologist right away if you have a new or worsening cough, shortness of breath, trouble breathing, or wheezing. They might pause Rasonque (daraxonrasib) to check your lungs. If needed, they might lower the dose or permanently stop treatment.
Harm to an unborn baby
- Risk factors: Pregnancy | Planning pregnancy | Can become pregnant or father a child
Based on animal studies, Rasonque (daraxonrasib) can harm an unborn baby. If you can become pregnant, your oncology care team will have you do a pregnancy test before starting treatment.
If you or your partner can become pregnant, use effective birth control during treatment and for 1 week after your last dose. Tell your oncologist right away if you or your partner becomes pregnant during treatment.
Rasonque (daraxonrasib) dosage
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 100mg of | 30 tablets | $19,590.65 | $653.02 |
| 150mg of | 60 tablets | $39,172.25 | $652.87 |
Typical dosage for Rasonque (daraxonrasib)
The typical dose is 300 mg by mouth once a day, with or without food.
Your oncologist might adjust your dose if you have bothersome side effects from the medication. They also might adjust your dose if you take certain medications that interact with Rasonque (daraxonrasib).
How much does Rasonque (daraxonrasib) cost?
$19,590.65
