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Protamine

Protamine Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on October 31, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low blood pressure
  • Slow heart rate

Less Common Side Effects

  • Back pain
  • Shortness of breath
  • Nausea
  • Vomiting
  • Flushing
  • Lacking energy

Protamine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: difficulty breathing, tightness in the throat, hives, fast heartbeat, dizziness, lightheadedness, swelling in the face or tongue

Source: DailyMed

The following Protamine side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Pulmonary hypertension—shortness of breath, chest pain, fast or irregular heartbeat, feeling faint or lightheaded, fatigue, swelling of the ankles or feet

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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