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Primidone

Primidone Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on December 4, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Tiredness
  • Dizziness
  • Feeling like the room is spinning (vertigo)
  • Problems with movement or coordination

Less Common Side Effects

  • Nausea
  • Vomiting
  • Poor appetite
  • Feeling irritable
  • Feeling emotional or having mood swings
  • Sexual dysfunction
  • Double vision
  • Eye twitching
  • Rash
  • Low blood cell counts

Primidone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal behavior or thoughts of self-harm
  • Low blood cell counts: frequent fevers, chills, weakness, tiredness, trouble breathing, unusual or easy bruising or bleeding
When do Primidone possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Drowsiness
Tiredness
Dizziness

Source: DailyMed

The following Primidone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Shakiness and unsteady walk

unsteadiness, trembling, or other problems with muscle control or coordination

Less common

Unusual excitement or restlessness (especially in children and in the elderly)

Rare

Chills

cough or hoarseness

fainting spells

fever and sore throat

fever with or without chills

general feeling of tiredness or weakness

irregular heartbeat

lower back or side pain

painful or difficult urination

pale skin

shortness of breath

skin rash

sores, ulcers, or white spots on the lips or in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Confusion

continuous, uncontrolled rolling eye movements

double vision

troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Clumsiness or unsteadiness

dizziness or lightheadedness

feeling of constant movement of self or surroundings

sensation of spinning

Less common

Decreased sexual ability

drowsiness

loss of appetite

mood or mental changes

nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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