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Ethosuximide

Ethosuximide Side Effects

Aileen Chu, PharmD, BCPSKristianne Hannemann, PharmD
Reviewed by Aileen Chu, PharmD, BCPS, Kristianne Hannemann, PharmD
Last reviewed on October 2, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Poor appetite
  • Stomach upset
  • Nausea or vomiting
  • Diarrhea
  • Stomach cramps or stomach pain
  • Drowsiness
  • Tiredness
  • Headache
  • Dizziness
  • Difficulty with walking, movement, or coordination
  • Difficulty concentrating
  • Weight loss

Less Common Side Effects

  • Swelling of the gums or tongue
  • Hiccups
  • Feeling extreme happiness or "high"
  • Feeling irritable
  • Feeling very hyper
  • Difficulty sleeping
  • Nightmares
  • Aggressiveness
  • Hives or rashes
  • Abnormal hair growth
  • Difficulty seeing things that are far away (nearsightedness)

Ethosuximide serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Low blood cell counts: getting sick more often, feeling weak or short of breath more than usual, easy bruising, bleeding gums or nose bleeds
  • Allergic reaction: severe rash; hives; blisters; difficulty breathing; swelling of the face, mouth, or throat
  • Suicidal thoughts or behavior

Source: DailyMed

The following Ethosuximide side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Changes in behavior

discouragement

feeling sad or empty

irritability

lack of appetite

loss of interest or pleasure

mood or mental changes

thoughts of killing oneself

tiredness

trouble with concentrating

trouble with sleeping

Incidence not known

Attack, assault, or force

blistering, peeling, or loosening of the skin

blood in the urine

bloody, black, or tarry stools

chest pain

cough or hoarseness

diarrhea

enlarged gums

false or unusual sense of well-being

fever and chills

fever with or without chills

general feeling of discomfort or illness

general feeling of tiredness or weakness

hair loss

headaches

high fever

hives, itching, and skin rash

joint or muscle pain

lower back or side pain

nervousness

not able to concentrate

painful or difficult urination

pale skin

red skin lesions, often with a purple center

red, irritated eyes

restlessness

shakiness and unsteady walk

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swelling around the eyes

swelling of the tongue

swollen, painful, or tender lymph glands in the neck, armpit, or groin

trouble sitting still

trouble with breathing

unexplained bleeding or bruising

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

unusual tiredness or weakness

vaginal bleeding

vision changes

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness

irregular, fast or slow, or shallow breathing

loss of consciousness

pale or blue lips, fingernails, or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

Incidence not known

Cramps

dizziness

drowsiness

heartburn

hiccups

increased hair growth, especially on the face

loss of appetite

nausea or vomiting

nearsightedness

pain or discomfort in the chest, upper stomach, or throat

redness of the skin

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Aileen Chu, PharmD, has over 8 years of experience working as a clinical pharmacist in the emergency department. Chu is also a pharmacotherapeutics instructor at Point Loma Nazarene University.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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