The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Injection-site redness (62%)
- Flu-like symptoms (47%)
- Fever (45%)
- Headache (44%)
- Muscle pain (19%)
- Chills (17%)
- Injection-site pain and itching (up to 15%)
- Weakness (13%)
- Joint pain (11%)
Less Common Side Effects
- Nausea
- Vomiting
- General pain and itching
- Overheating
- Injection-site rash, swelling, or warmth
Plegridy serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Depression and thoughts of self-harm
- Seizures
- Serious allergic reactions: hives, itching, swelling of face or tongue, difficulty breathing
- Liver damage: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion
- Heart failure: shortness of breath, swelling in legs, ankles, or feet, coughing, fatigue, weakness
- High blood pressure in the lungs: shortness of breath, fatigue, swelling, chest pain, lips and fingers turning blue
- Low blood cell counts: fever, pale skin, fast heart rate, lightheadedness, easy bleeding or bruising
Source: DailyMed
The following Plegridy side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- High thyroid levels (hyperthyroidism)—fast or irregular heartbeat, weight loss, excessive sweating or sensitivity to heat, tremors or shaking, anxiety, nervousness, irregular menstrual cycle or spotting
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Low thyroid levels (hypothyroidism)—unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression
- Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
- Pulmonary arterial hypertension (PAH)—shortness of breath, unusual weakness or fatigue, swelling of the ankles, hands, or feet, dizziness, feeling faint or lightheaded, chest pain, fast or irregular heartbeat, blue skin or lips
- Seizures
- Stomach pain, bloody diarrhea, pale skin, unusual weakness or fatigue, decrease in the amount of urine, which may be signs of hemolytic uremic syndrome
- TTP—purple spots on the skin or inside the mouth, pale skin, yellowing skin or eyes, unusual weakness or fatigue, fever, fast or irregular heartbeat, confusion, change in vision, trouble speaking, trouble walking
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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