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Glatiramer

Glatiramer Side Effects

Kristianne Hannemann, PharmDConnie Zheng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Connie Zheng, PharmD
Last reviewed on May 26, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Warmth at injection site (43%)
  • Pain at injection site (40%)
  • Infection (30%)
  • Itching and swelling at injection site (up to 27%)
  • Weakness (22%)
  • General body pain (20%)
  • Rash (19%)
  • Nausea (15%)
  • Trouble catching your breath (14%)
  • Anxiety (13%)
  • Chest pain (13%)
  • Back pain (12%)

Less Common Side Effects

  • Pounding heart
  • Vomiting
  • Swelling from fluids
  • Fever
  • Runny nose
  • Cough
  • Cramps, diarrhea, and other symptoms of the stomach bug

Glatiramer serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Immediate reactions after injection: throat tightness, difficulty breathing
  • Injection site necrosis (skin cell death): blue-black discoloration, swelling, broken skin, dent in skin
  • Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, nausea
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Source: DailyMed

The following Glatiramer side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxiety

bleeding, hard lump, hives or welts, itching, pain, redness, or swelling at the injection site

chest pain

cough or hoarseness

excessive muscle tone

fast, irregular, pounding, or racing heartbeat or pulse

feeling of warmth

fever or chills

joint pain

lower back or side pain

neck pain

painful or difficult urination

redness of the face, neck, arms, and occasionally, upper chest

skin rash

swelling or puffiness of the face

swollen, painful, or tender lymph glands in the neck, armpit, or groin

trouble breathing

Less common

Agitation

bloating or swelling

confusion

difficulty with swallowing

feeling faint, dizzy, or lightheaded

headache, severe and throbbing

itching of the vagina or outside genitals

muscle aches or pain

pain during sexual intercourse

purple spots under the skin

red streaks on the skin

shakiness in the legs, arms, hands, or feet

small lumps under the skin

spasm of the throat

strong urge to urinate

sweating

swelling of the fingers, arms, feet, or legs

thick, white curd-like vaginal discharge without odor or with mild odor

tightness in the chest

tingling of the hands or feet

trembling or shaking of the hands or feet

unusual weight gain or loss

Rare

Blood in the urine

burning or stinging of the skin

continuous, uncontrolled back-and-forth or rolling eye movements

decreased sexual ability

diarrhea

difficulty with moving

ear pain

fast breathing

irritation of the mouth and tongue (thrush)

loss of appetite

menstrual pain or changes

painful cold sores or blisters on the lips, nose, eyes, or genitals

sensation of motion, usually whirling, either of oneself or of one's surroundings

speech problems

vision problems

Incidence not known

Abnormal vaginal bleeding or discharge

back pain, sudden and severe

bleeding gums

blindness

blurred or decreased vision

chest discomfort or heaviness

clear or bloody discharge from the nipple

cloudy urine

coughing up blood

dark urine

decreased urine output

difficult or frequent urination

dilated neck veins

dimpling of the breast skin

drowsiness

extreme tiredness or weakness

eye pain

gaseous stomach pain

general feeling of discomfort or illness

general tiredness and weakness

hair loss

headache

heartburn

increased menstrual flow or vaginal bleeding

indigestion

inverted nipple

joint swelling

large amount of cholesterol in the blood

light-colored stools

lump in the breast or under the arm

lump or swelling in the stomach

muscle weakness, sudden and progressing

nausea

nerve pain

nosebleed

pain or discomfort the in arms or jaw

paralysis

persistent crusting or scaling of the nipple

prolonged bleeding from cuts

puffiness or swelling of the eyelids or around the eyes, lips, or tongue

rapid, shallow breathing

recurrent fever

red or black, tarry stools

redness or swelling of the breast

seizures

sore on the skin of the breast that does not heal

sore throat

stiff neck or back

stomach bloating, burning, cramping, or pain

tearing

tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

unusual tiredness or weakness

upper right abdominal or stomach pain

vomiting

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Lack or loss of strength

stuffy or runny nose

Less common

Double vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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