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Deramaxx for Dogs: A Pain Medication for Arthritis and After Surgery

Catherine Barnette, DVMGhanasyam Bey, DVM
Published on June 12, 2024

Key takeaways:

  • Deramaxx is a non-steroidal anti-inflammatory drug (NSAID) that can treat pain and inflammation in dogs. 

  • The most common side effect associated with Deramaxx is stomach upset, including decreased appetite, nausea, vomiting, or diarrhea.

  • Deramaxx comes in chewable tablets. Your veterinarian will determine the best dosage for your dog based on their weight and the condition being treated. 

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A vet examines a dog's paw.
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If your dog has arthritis or an acute injury, you’ve probably noticed some signs of pain. To help manage your dog’s pain, your veterinarian may prescribe deracoxib (Deramaxx). 

This medication blocks chemical signals in the body that contribute to pain and inflammation, making your dog more comfortable. Side effects may occur, but fortunately, serious side effects are rare.

Let’s take a look at the details, so you know what to expect if your dog is prescribed Deramaxx.

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Deramaxx for dogs at a glance

Common names

Deracoxib (Deramaxx)

What it treats

Pain and inflammation

How it comes (forms)

Chewable tablets

Common side effects

Decreased appetite, nausea, vomiting, diarrhea

Average cost

About $80 for a 30-day supply

What is Deramaxx for dogs and how does it work?  

Deramaxx is a non-steroidal anti-inflammatory drug (NSAID). You may already be familiar with this type of medication; people often take NSAIDs like ibuprofen for their own aches and pains. You can’t give human NSAIDs to dogs because they’re toxic. However, veterinary NSAIDs like Deramaxx can safely and effectively treat pain in pets. 

Deramaxx works by blocking the body’s production of prostaglandins. These substances are associated with pain and inflammation. By blocking prostaglandin production, Deramaxx reduces these symptoms in dogs.

What is Deramaxx used for in dogs?

Deramaxx treats pain and inflammation. So veterinarians prescribe Deramaxx for a variety of conditions. It’s FDA approved to treat arthritis and pain after surgery. But that’s not all your vet might prescribe this medication for.

Your veterinarian may prescribe Deramaxx to treat pain and inflammation caused by: 

  • Osteoarthritis

  • Injuries (wounds, broken bones, muscle sprains/strains) 

  • Surgery (spay, neuter, dental extraction)

  • Some types of cancer 

How is Deramaxx dosed and given for dogs?

Deramaxx is a once-daily chewable tablet. It’s available in four different tablet sizes: 12 mg, 25 mg, 75 mg, and 100 mg. Your veterinarian will determine the best Deramaxx dose for your dog. 

The dose is based on your dog’s weight and the condition being treated. If your dog is prescribed Deramaxx for pain after surgery, they may only take the medication for a few days. But to treat arthritis, your dog may need to take Deramaxx every day for a longer period of time.

Your veterinarian may prescribe a higher dose for the first few days of treatment, and then a lower dose in following days. In some situations, this approach can maximize the benefits of Deramaxx while minimizing the risk of side effects. In other cases, you may give the same dose of Deramaxx every day. 

Follow your veterinarian’s instructions closely when giving Deramaxx. 

What are the common side effects of Deramaxx in dogs?

Although NSAIDs offer numerous benefits, they can also have side effects. Humans taking NSAIDs may experience gastrointestinal distress, and dogs are no different. 

The most common gastrointestinal effects associated with Deramaxx include: 

  • Decreased appetite

  • Nausea

  • Vomiting

  • Diarrhea

You can reduce the risk of these side effects by giving Deramaxx with a full meal. 

If your dog develops any gastrointestinal problems while taking Deramaxx, stop giving the medication and contact your veterinarian. Your veterinarian will help you determine the best course of action for your pet. 

What are the most serious risks of Deramaxx for dogs?

There are a few serious potential health risks associated with the use of Deramaxx in dogs: 

  1. Gastrointestinal ulcers: Like people taking NSAIDs for chronic ailments, dogs can experience stomach or intestinal ulcers with Deramaxx use. Fortunately, this effect is rare. Deramaxx is significantly less likely to cause ulcers than aspirin treatment.  

  2. Liver disease: Deramaxx may worsen pre-existing liver disease. Additionally, a very small number of dogs may have an idiosyncratic (unpredictable) reaction to the medication that causes liver injury. 

  3. Kidney disease: Deramaxx may exacerbate pre-existing kidney disease.

Your veterinarian will perform blood tests before starting your dog on a prolonged course of Deramaxx. Dogs with normal blood tests are less likely to have pre-existing liver disease, so they are less likely to develop liver problems while on this medication. 

Dogs on long-term Deramaxx also need regular monitoring. Your veterinarian will perform regular physical exams and blood tests, so any side effects associated with Deramaxx can be found and treated quickly. 

Does Deramaxx interact with any other dog medications?

Deramaxx and other NSAIDs can interact with a variety of other medications. Be sure your veterinarian knows about anything your dog is taking, including prescription medications, over-the-counter medications, and nutritional supplements. This will help your veterinarian avoid potential interactions. 

Do not combine Deramaxx with other NSAIDs or steroids (such as prednisone). This significantly increases the risk of harmful effects. 

Other medications that may interact with Deramaxx include: 

  • ACE inhibitors

  • Anticoagulants

  • Cyclosporine

  • Diuretics

  • Phenobarbital 

  • Some antibiotics 

  • Some medications for diabetes

  • Some chemotherapy medications 

What should you do if your dog misses a dose of Deramaxx?

If your dog misses a dose of Deramaxx, give the missed dose as soon as you remember. If it’s almost time for your dog’s next dose, then skip the missed dose. Instead, give your dog their scheduled dose as soon as it is time to do so. 

The bottom line

Deramaxx is a safe and effective treatment for pain and inflammation in dogs. It’s often used to treat pain after surgery or arthritis pain. However, like NSAIDs in humans, Deramaxx can cause side effects. The most common side effects in dogs include vomiting, loss of appetite, and diarrhea. Work with your veterinarian before and during treatment to minimize potential risks to your pet while maximizing the benefits associated with this medication. 

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Why trust our experts?

Catherine Barnette, DVM
Catherine Barnette, DVM, is a small animal veterinarian with 14 years of experience providing preventive care, medical workups, and surgical services in a number of general veterinary practices. She also served on her county's board of health for several years and taught biology laboratories for college students.
Renée Fabian, MA
Renée Fabian is the senior pet health editor at GoodRx. She’s worked for nearly 10 years as a journalist and editor across a wide range of health and well-being topics.
Ghanasyam Bey, DVM
Reviewed by:
Ghanasyam Bey, DVM
Ghanasyam Bey, DVM, is from Cleveland, Ohio, and attended Princeton University for undergraduate studies. After a year of biology research at Duke University, he attended Ohio State College of Veterinary Medicine.

References

Brooks, W. (2020). Deracoxib (Deramaxx). Veterinary Partner.

Cornell University College of Veterinary Medicine. (n.d.). NSAID (non-steroidal anti-inflammatory drug) medication guide for animals.

View All References (4)
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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