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Oxymorphone Coupon - Oxymorphone 10mg tablet

oxymorphone

Generic Opana
Used for Pain
Used for Pain

Oxymorphone is an opioid medication. It's used to treat severe pain not relieved by non-opioid medications. Oxymorphone comes as an immediate-release (IR) tablet that's taken by mouth, typically 4 to 6 hours. It also comes as an extended-release (ER) tablet that's usually taken every 12 hours. To lower the risk of opioid use disorder, the pain specialist will prescribe the lowest dose for the shortest duration of time needed to treat your symptoms. Side effects of this medication include nausea, sleepiness, and dizziness. Brand names Opana and Opana ER both have been discontinued.

Last reviewed on October 14, 2024
Oxymorphone is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Oxymorphone?

What is Oxymorphone used for?

How Oxymorphone works

Oxymorphone is an opioid. It attaches to certain opioid receptors in your brain to lessen how much pain you feel.

Are you looking for information on oxycodone (Roxicodone) instead?

Drug Facts

Common BrandsOpana (brand no longer available)
Drug ClassOpioid
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Oxymorphone essentials

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$334.15(save 85.87%)
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What are the risks and warnings for Oxymorphone?

Oxymorphone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Potential for addiction and misuse

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health problems

    Oxymorphone is a controlled substance because it has a risk for misuse and addiction. To lower this risk, your pain specialist will prescribe you the lowest dose needed to manage your pain for the shortest period of time. Take the medication exactly as prescribed. Don't change how much or how often you take it without talking to your prescriber first.

    Never break or crush oxymorphone ER because this medication has a special coating that allows it to be slowly released in your body. Damaging the coating will cause the body to absorb too much medication too quickly and put you at very high risk for serious and life-threatening side effects, such as dangerously slow breathing and trouble staying awake.

    Because of the risk for misuse and addiction, oxymorphone is only available through a Risk Evaluation and Mitigation Strategy (REMS) program called the Opioid Analgesic REMS program. Your prescriber and pharmacy must register with the program, receive training on proper medication use, and discuss with you about how to take oxymorphone safely.

    risk-warning

    Dangerously slow breathing (respiratory depression)

    • Risk factors: Taking medications that can cause slow breathing | Drinking alcohol | Older age | Being frail | Medical conditions that cause breathing problems (e.g., COPD, asthma, head injury) | Taking too much oxymorphone

      Oxymorphone can cause dangerously slow breathing, which can be life-threatening. This can happen to anyone and even at recommended doses. But the risk is greatest when you first start treatment or when your pain specialist raises your dose.

      Your pain specialist will recommend that you have naloxone (Narcan) to carry with you at all times. Naloxone is a medication that can reverse slowed breathing from opioids. Use naloxone, call 911, and get medical help right away if you or your loved one notices that you have trouble breathing or have bluish-colored lips, fingers, or toes.

      risk-warning

      Risk for opioid overdose

      • Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of oxymorphone | Taking more opioids than prescribed | Alcohol use

        Take oxymorphone exactly as prescribed. Taking too much medication or taking it more often than prescribed can lead to an overdose. It can be very dangerous if someone accidentally swallows the medication. Be sure to keep oxymorphone out of reach from children, pets, and visitors to prevent accidental exposure or overdose.

        Symptoms of an opioid overdose include not responding to sound or touch, extremely slow breathing, slow heartbeat, extreme sleepiness, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will recommend getting naloxone (Narcan) — either by prescription or over the counter. Naloxone can help treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.

        risk-warning

        Difficulty concentrating and extreme sleepiness

        • Risk factors: Taking high doses of oxymorphone | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness

          Oxymorphone can cause extreme sleepiness and lower your ability to think, react, and focus. Don't drink alcohol with oxymorphone. Also don't take oxymorphone with other medications that can cause sleepiness or "brain fog" (e.g., benzodiazepines, muscle relaxants, sleep medications). Otherwise, these side effects might worsen.

          Make sure you know how oxymorphone affects you before driving a car or doing activities that require your concentration. Talk to your prescriber right away if you feel too sleepy from the medication.

          risk-warning

          Serious interactions

          Oxymorphone can have serious interactions with alcohol and several medications. For example, drinking alcohol while you're taking oxymorphone can put you at serious risk for drowsiness and confusion. Also, taking oxymorphone with medications that slow your body down (e.g., benzodiazepines, other opioids, muscle relaxants) can put you at risk for having dangerously slow breathing.

          Let your care team know what medications you're taking to make sure they're safe for you to take together. Also speak with your care team first before making any changes to your medications because sudden dose adjustments can be harmful.

          risk-warning

          Harm to newborn babies

          Long-term use of oxymorphone during pregnancy can cause your unborn baby to become dependent on the medication. This is because oxymorphone can pass through the placenta to your unborn baby.

          Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding behavior, trembling, abnormal sleep patterns, and even seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare professional (HCP) know if you've taken oxymorphone during pregnancy or if you notice these symptoms in your baby.

          risk-warning

          Physical dependence and withdrawal

          • Risk factors: Long-term use of oxymorphone

            If taken regularly for a long time, oxymorphone can cause physical dependence. This means that your body relies on the medication to function. And you might experience withdrawal if you lower your dose too quickly or suddenly stop taking the medication. Withdrawal symptoms include anxiety, restlessness, irritability, runny nose, yawning, sweating, and chills.

            Don't suddenly lower your dose or stop taking oxymorphone suddenly without talking to your prescriber first. If you need to stop this medication, your prescriber will slowly lower your dose over time to prevent withdrawal symptoms. Talk to an HCP if you have concerns about taking oxymorphone because of the risk for withdrawal.

            risk-warning

            Serious allergic reaction

            Some people have experienced serious allergic reactions after taking oxymorphone. Symptoms have included swelling of the face and tongue, hives, rash, nausea and vomiting. If you experience any of these symptoms, let your healthcare team know. They might ask you to stop taking oxymorphone and consider other options.

            risk-warning

            Low blood pressure

            Oxymorphone can cause extremely low blood pressure. For example, your blood pressure might suddenly drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to an HCP if dizziness or lightheadedness doesn't go away.

            risk-warning

            Low adrenal hormone levels

            • Risk factors: Taking oxymorphone for longer than 1 month

              Some people taking opioid medications like oxymorphone have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month.

              Tell your healthcare team if you have symptoms of low adrenal hormone levels, such as tiredness, dizziness, weakness, not feeling hungry, nausea, and vomiting. If your adrenal hormone levels are too low, you might need to stop oxymorphone and get treated with corticosteroids.

              risk-warning

              Seizures

              • Risk factors: History of seizure conditions

                If you've had a seizure in the past, oxymorphone can raise the risk of having seizures more often. Opioids can also raise your risk of seizures in certain situations. Get medical help immediately if you have a seizure while you're taking oxymorphone.

                More on Oxymorphone warnings

                basics-icon

                What are the side effects of Oxymorphone?

                The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                Common Side Effects

                Immediate-release tablet
                • Nausea (19%)
                • Fever (14%)
                • Sleepiness (9%)
                • Vomiting (9%)
                • Itching (8%)
                • Headache (7%)
                • Dizziness (7%)
                Extended-release tablet
                • Nausea (33%)
                • Constipation (28%)
                • Dizziness (18%)
                • Sleepiness (17%)
                • Vomiting (16%)
                • Itching (15%)
                • Headache (12%)
                • Sweating (9%)
                • Dry mouth (6%)

                Other Side Effects

                Immediate-release tablet
                • Constipation
                • Confusion
                • Dry mouth
                • Passing pass
                • Feeling anxious
                Extended-release tablet
                • Diarrhea
                • Trouble sleeping
                • Tiredness
                • Low appetite
                • Stomach pain

                Serious Side Effects

                Contact your healthcare provider immediately if you experience any of the following.
                • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
                • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, slow heartbeat, extreme sleepiness, cold or clammy skin
                • Opioid withdrawal: anxiety, suicidal thoughts, restlessness, irritability, runny nose, yawning, sweating, chills, wide pupils
                • Serious allergic reaction: itchy, red rash (hives); shortness of breath; chest tightness; swelling of lips, tongue, throat, face, or eyes

                Source: DailyMed

                The following side effects have also been reported

                Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

                Check with your doctor immediately if any of the following side effects occur:

                Less common

                Blurred vision

                confusion

                decreased urination

                difficult or labored breathing

                dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

                dry mouth

                fast, pounding, racing, or irregular heartbeat or pulse

                headache

                nervousness

                pounding in the ears

                rapid breathing

                sunken eyes

                sweating

                swelling of the hands, ankles, or feet

                thirst

                tightness in the chest

                unusual tiredness or weakness

                wrinkled skin

                Rare

                Chest pain or discomfort

                chills

                cold sweats

                confusion about identity, place, and time

                cough

                decrease in consciousness

                deep or fast breathing with dizziness

                difficulty in passing urine (dribbling)

                difficulty with sleeping

                difficulty with swallowing

                drowsiness to profound loss of consciousness

                fever

                hives, itching, or skin rash

                hoarseness

                irregular, slow, or shallow breathing

                irritability

                irritation

                joint pain, stiffness, or swelling

                numbness of the feet, hands, and around the mouth

                painful urination

                pale or blue lips, fingernails, or skin

                puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

                redness of the skin

                restlessness

                seeing, hearing, or feeling things that are not there

                severe constipation

                severe vomiting

                stomach pain

                shaking

                trouble in holding or releasing urine

                unusual drowsiness, dullness, or feeling of sluggishness

                Incidence not known

                Agitation

                darkening of the skin

                diarrhea

                large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

                loss of appetite

                mental depression

                nausea

                overactive reflexes

                poor coordination

                seizures

                shivering

                talking or acting with excitement you cannot control

                twitching

                vomiting

                Get emergency help immediately if any of the following symptoms of overdose occur:

                Symptoms of overdose

                Cold and clammy skin

                constricted, pinpoint, or small pupils (black part of the eye)

                decreased awareness or responsiveness

                difficult or troubled breathing

                irregular, fast, slow, or shallow breathing

                low blood pressure or pulse

                muscle weakness

                pale or blue lips, fingernails, or skin

                severe sleepiness or unusual drowsiness

                very slow breathing

                Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

                More common

                Difficulty having a bowel movement

                feeling of constant movement of self or surroundings

                relaxed and calm

                sensation of spinning

                sleepiness

                Less common

                Belching

                decreased weight

                discouragement

                excess air or gas in the stomach or bowels

                feeling of warmth

                feeling sad or empty

                full or bloated feeling

                heartburn

                indigestion

                lack of appetite

                loss of interest or pleasure

                passing gas

                pressure in the stomach

                redness of the face, neck, arms, and occasionally, upper chest

                stomach discomfort or upset

                swelling of the abdominal or stomach area

                tiredness

                trouble concentrating

                Rare

                Blistering, crusting, irritation, itching, or reddening of the skin

                cracked, dry, scaly skin

                difficulty with thinking or concentrating

                disturbed color perception

                double vision

                false or unusual sense of well-being

                feeling jittery

                halos around lights

                loss of vision

                night blindness

                nightmares or unusually vivid dreams

                overbright appearance of lights

                sudden sweating

                tunnel vision

                welts

                Incidence not known

                Forgetfulness

                loss of memory

                problems with memory

                Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

                Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

                pros-and-cons

                Pros and cons of Oxymorphone

                thumbs-up

                Pros

                Taken by mouth

                Possible option for pain not eased by non-opioid medications

                Comes in both short-acting and long-acting tablets

                thumbs-down

                Cons

                High risk of misuse, dependence, and addiction

                Needs to be taken on an empty stomach

                Only available as a tablet

                pharmacist-tips

                Pharmacist tips for Oxymorphone

                pharmacist
                • Take oxymorphone on an empty stomach at least 1 hour before or 2 hours after eating. Food can affect how oxymorphone is absorbed into your body and put you at higher risk for side effects.

                  • Swallow the oxymorphone extended-release tablet whole with a glass of water. Don't chew, break, crush, or tamper with the tablet because it can cause too much medication to be released all at once in your body, which can put you at risk for serious and life-threatening side effects.

                    • Make sure to tell your care team about all the medications you're taking before and during treatment with oxymorphone. Your care team should review your medication list to make sure your medications are safe to take together. Oxymorphone can have harmful interactions with other medications, like certain antidepressants and benzodiazepines.

                      • You might experience constipation after taking oxymorphone. To lower the risk, drink enough water each day and add more foods with fiber to your diet. Speak to your care team if these lifestyle changes aren't enough to help with this side effect. They can talk with you about other options.

                        • Oxymorphone can make you sleepy and affect your ability to think, react, and focus. Don't drive or do activities where you need to focus until you know how this medication affects you.

                          • Don't drink alcohol while you're taking oxymorphone. Mixing them together can make you very sleepy or dizzy and unable to think clearly. It can also harm your liver.

                            • Don't suddenly stop taking oxymorphone without talking to your prescriber first. Doing so can lead to withdrawal symptoms like muscle aches, chills, and trouble sleeping. If you want to stop oxymorphone, your pain specialist can lower your dose slowly over time to help you stop safely.

                              • People who take an opioid medication are recommended to have naloxone (Narcan) with them at all times. Naloxone is a medication that's used to help reverse the effects of oxymorphone in situations like an accidental overdose. Teach your loved ones about how to give naloxone to you if you can't do it yourself. Be sure to call for emergency help if you need to use naloxone because its effects are temporary.

                                • Keep oxymorphone out of reach from children, pets, or visitors. There are a few drug take-back options to get rid of the medication safely if you don't need to take it anymore. This lessens the risk for accidental overdose and medication misuse.

                                  faqs

                                  Frequently asked questions about Oxymorphone

                                  How long does oxymorphone stay in your system?
                                  It takes about 2.5 days for most of oxymorphone IR to leave the body after a dose. And it takes about 5 days for most of oxymorphone ER to leave the body after a dose. These time-frames are estimated based on the half-life of the medications. Talk to your prescriber if you have concerns about how long oxymorphone stays in the body.
                                  What happens when you take too much oxymorphone?
                                  Taking too much oxymorphone raises the risk of overdose, which can lead to life-threatening symptoms like trouble breathing and loss of consciousness. Taking more than the prescribed amount of oxymorphone can also lead to dependence or opioid use disorder. To lower the risk of these serious problems, your pain specialist will only prescribe the lowest dose of oxymorphone for the shortest duration time needed to treat your symptoms. Talk with your healthcare team if you have more questions about the side effects of this medication.
                                  Can I take oxymorphone with acetaminophen (Tylenol) or ibuprofen (Advil)?
                                  Ask your pain specialist or healthcare team if you can take oxymorphone with ibuprofen (Advil) or acetaminophen (Tylenol). These medications aren't known to have serious interactions. But the combination might not be appropriate for everyone. For example, both oxymorphone and acetaminophen (Tylenol) might not be appropriate for people with liver problems. And ibuprofen (Advil) might not be a good choice for people with certain heart risks. Before you take other pain relievers with oxymorphone, speak with your healthcare team to make sure it's safe for you to do so.
                                  What's the difference between oxymorphone and oxycodone?
                                  Both oxymorphone and oxycodone are opioid pain medications. They're chemically similar to each other. But they differ slightly in how they're absorbed and how they affect the pain receptors in the body. Because they're both opioid medications, they can cause similar side effects, including dizziness and constipation. They can both raise your risk for serious problems, like dependence and trouble breathing. Talk to your prescriber if you have specific questions about the differences between both medications.
                                  Are oxymorphone and Opana the same thing?
                                  Yes, oxymorphone is the active medication for brand name Opana. But Opana and Opana ER have been discontinued. Oxymorphone is only available as a generic.
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                                  dosage

                                  Oxymorphone dosage forms

                                  The average cost for 60 tablets of 10mg of Oxymorphone is $58.45 with a free GoodRx coupon. This is 82.51% off the average retail price of $334.15.
                                  tablet
                                  Tablet
                                  DosageQuantityPrice as low asPrice per unit
                                  5mg60 tablets$47.20$0.79
                                  10mg60 tablets$58.45$0.97

                                  Typical dosing for Oxymorphone

                                  Your pain specialist will work with you to find the right dose for your individual needs. It's recommended to take the lowest dose possible for the shortest duration of time to manage your pain.

                                  • Immediate-release tablet: The typical starting dose is 10 mg by mouth every 4 to 6 hours as needed for pain on an empty stomach, an hour before or 2 hours after eating.

                                  • Extended-release tablet: The typical starting dose is 5 mg by mouth every 12 hours on an empty stomach, an hour before or 2 hours after eating.

                                  interactions

                                  Interactions between Oxymorphone and other drugs

                                  Oxymorphone may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Oxymorphone. Please note that only the generic name of each medication is listed below.

                                  Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                  Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                  drug-cost

                                  How much does Oxymorphone cost?

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                                  contraindications-icon

                                  Oxymorphone contraindications

                                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Oxymorphone will not be safe for you to take.
                                  • Severely slowed breathing (respiratory depression)

                                  • Severe asthma

                                  • Conditions that cause blockage of the stomach passageway

                                  • Moderate or severe liver disease

                                  images

                                  Oxymorphone images

                                  White Round 54 814 - Oxymorphone Hydrochloride 10mg Tablet
                                  This medicine is White, Round Tablet Imprinted With "54 814".White Round 54 814 - Oxymorphone Hydrochloride 10mg Tablet
                                  Red Round K 71 - Oxymorphone Hydrochloride 10mg Tablet
                                  This medicine is Red, Round Tablet Imprinted With "K 71".Red Round K 71 - Oxymorphone Hydrochloride 10mg Tablet
                                  Yellow Round Cor 259 - Oxymorphone Hydrochloride 10mg Tablet
                                  This medicine is Yellow, Round Tablet Imprinted With "Cor 259".Yellow Round Cor 259 - Oxymorphone Hydrochloride 10mg Tablet

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                                  References

                                  Best studies we found

                                  Amneal Pharmaceuticals of New York LLC. (2024). Oxymorphone hydrochloride tablet, film coated, extended release [package insert]. DailyMed.

                                  Aurolife Pharma, LLC. (2024). Oxymorphone hydrochloride tablet [package insert]. DailyMed.

                                  Centers for Disease Control and Prevention. (2024). About opioid use during pregnancy.

                                  View All References (5)

                                  Jansson, L. M., et al. (2019). Neonatal abstinence syndrome. Pediatric Clinics of North America.

                                  National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Adrenal insufficiency & Addison’s disease.

                                  National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & Causes of adrenal insufficiency & Addison's disease.

                                  Sloan, P. (2008). Review of oral oxymorphone in the management of pain. Therapeutics and Clinical Risk Management.

                                  U.S. Food and Drug Administration. (2024). Drug disposal: Drug take-back options.

                                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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