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Osphena
Used for Atrophic Vaginitis, Menopause
Used for Atrophic Vaginitis, Menopause
Osphena (ospemifene) is a medication that helps with vaginal dryness and painful sex for people who have gone through menopause. This medication belongs to a drug class called selective estrogen receptor modulators, or SERMs. Osphena (ospemifene) is a tablet that's taken by mouth once every day. Some side effects include hot flashes and vaginal discharge.
What is Osphena (ospemifene)?
What is Osphena (ospemifene) used for?
- Painful sex caused by menopause
- Vaginal dryness caused by menopause
How Osphena (ospemifene) works
Estrogen helps moisten the lining of your vagina. During menopause, your estrogen levels drop, which cause your vagina to become dry and irritated. This can make sex painful and uncomfortable.
Osphena (ospemifene) is a selective estrogen receptor modulator, or SERM for short. This medication acts like estrogen in your vaginal tissue. This helps relieve vaginal dryness and make sex less painful.
Drug facts
| Common Brands | Osphena |
|---|---|
| Drug Class | Selective estrogen receptor modulator (SERM) |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Osphena (ospemifene) essentials
Side effects of Osphena (ospemifene)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Hot flashes (12%)
- Vaginal discharge (6%)
- Muscle spasms (5%)
Less Common Side Effects
- Headaches
- Excessive sweating
- Vaginal bleeding
- Night sweats
Osphena (ospemifene) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Blood clot in arm or leg: swelling, pain, or tenderness in the arm or leg; skin that's warm to the touch
- Blood clot in the lung: trouble breathing, chest pain
- Heart attack: chest pain, arm pain, shortness of breath, cold sweat, lightheadedness
- Stroke: sudden weakness on one side of the body, drooping face, changes in your speech or vision, confusion, bad headache
- Abnormal vaginal bleeding that doesn't go away or keeps happening
The following Osphena (ospemifene) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Vaginal bleeding
Incidence not known
change in vaginal discharge
dizziness or lightheadedness
fainting
fast heartbeat
hoarseness
irritation
joint pain, stiffness, or swelling
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
pain or feeling of pressure in the pelvis
pain, redness, or swelling in the arm or leg
redness of the skin
swelling of the eyelids, face, lips, hands, or feet
tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
tightness in the chest
troubled breathing or swallowing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Feeling of warmth
redness of the face, neck, arms, and occasionally, upper chest
sudden sweating
white or brownish vaginal discharge
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$896.19
Manufacturer exclusive discount
$205.20
Pros and cons of Osphena (ospemifene)
Pros
- Taken just once daily
- Generally well tolerated
Cons
- Might have bothersome hot flashes
- Might not be the best option for people with risk factors for blood clots or for people with severe liver problems
- No lower-cost generic available; brand name only
Pharmacist tips for Osphena (ospemifene)
- Take Osphena (ospemifene) once a day with food. Taking the medication with food helps it get absorbed into the body better.
- It's normal to experience hot flashes, vaginal discharge, and sweating while you're taking Osphena (ospemifene). Talk to a healthcare professional if these symptoms become too bothersome for you.
- If you have a hot flash, it's recommended to limit how much spicy foods you eat or how much alcohol and caffeine you drink. These foods and beverages can make hot flashes feel worse. Keep a fan nearby and keep your room cool to help you feel more comfortable when you get hot flashes.
- Tell your prescriber about any planned surgeries or bedrest. Some types of surgeries and periods of time when you won't be moving much can put you at risk for blood clots while you're taking Osphena (ospemifene). Your prescriber can tell you when to stop taking Osphena (ospemifene) — typically at least 4 to 6 weeks before — and when you can restart the medication. This helps lower the risk for blood clots.
- Don't take other estrogen medications to help with menopause symptoms with Osphena (ospemifene). We don't know how safe it is to take these medications at the same time.
Risks and warnings for Osphena (ospemifene)
Osphena (ospemifene) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk for blood clots, stroke, or heart attack
- Risk factors: Personal or family history of blood clots | High blood pressure | High blood sugar (diabetes) | High cholesterol | Tobacco use | Systemic lupus erythematosus (SLE)
Though rare, some people who took Osphena (ospemifene) developed a blood clot during clinical studies with the medication. Sometimes, these blood clots led to a heart attack or stroke. Let your prescriber know about your full medical history so they can check your risk for blood clots before you start taking Osphena (ospemifene).
Be aware of the signs and symptoms of a blood clot, heart attack, and stroke.
- Blood clot in arm or leg: swelling or pain in the arm or leg
- Blood clot in the lung: chest pain, trouble breathing
- Heart attack (blood clot near the heart): chest pain, arm pain, shortness of breath, a cold sweat, lightheadedness
- Stroke (blood clot in the brain): sudden weakness on one side of the body, drooping face, trouble breathing, bad headache, changes in speech or vision
Stop taking Osphena (ospemifene) and get medical help right away if you have any signs or symptoms of a blood clot.
Uterine or endometrial cancer
- Risk factors: Estrogen therapy without additional progestin | People with a uterus | Using estrogen therapy for more than 1 year
Osphena (ospemifene) acts like estrogen in your uterus. It can thicken and change the lining of your uterus, called the endometrium. Uncontrolled growth of the uterus lining can cause uterine or endometrial cancer in people with a healthy uterus. In general, the risk for endometrial cancer is higher in people who take estrogen therapy without progestin (another hormone) to balance out estrogen's effect on the growth of the uterine lining.
Although studies found that Osphena (ospemifene) thickens the lining of the uterus a little, there haven't been any reported cases of endometrial cancer in people who've taken the medication yet. And taking a progestin with Osphena (ospemifene) hasn't been studied, so it's not clear whether taking a progestin with this medication is beneficial.
To be safe, be aware of warning symptoms of uterine (endometrial) cancer, including vaginal bleeding that doesn't go away or keeps coming back or pelvic pain. Let your healthcare team know if you notice any unusual vaginal bleeding. Speak with your prescriber if you're worried about Osphena (ospemifene) and uterine cancer.
Breast cancer
- Risk factors: History of breast cancer
Osphena (ospemifene) hasn't been studied in people with breast cancer. It's unclear whether this medication can affect your risk for breast cancer. To be safe, you shouldn't take Osphena (ospemifene) if you currently have or have had breast cancer in the past. Remember to regularly do a breast cancer self-exam to check for any changes and get your scheduled breast scans (mammograms) done. Let your prescriber or primary care provider know if you notice any unusual changes to your breasts.
Osphena (ospemifene) dosage
The average cost for 90 tablets of 60mg of of Osphena (ospemifene) is $205.20 with a free GoodRx coupon. This is 77.10% off the average retail price of $896.19. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 60mg of | 90 tablets | $205.20 | $2.28 |
Typical dosage for Osphena (ospemifene)
The typical dose is 60 mg by mouth once daily with food.
Interactions between Osphena (ospemifene) and other drugs
Osphena (ospemifene) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Osphena (ospemifene). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abiraterone Acetate
- Amiodarone
- Ceritinib
- Clarithromycin
- Eslicarbazepine Acetate
- Fluconazole
- Fluvoxamine
- Ketoconazole
- Piperaquine
- Regorafenib
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amobarbital
- Aprobarbital
- Bosentan
- Butabarbital
- Butalbital
- Carbamazepine
- Dexamethasone
- Efavirenz
- Enzalutamide
- Etravirine
- Fosphenytoin
- Mephobarbital
- Methohexital
- Modafinil
- Nafcillin
- Nevirapine
- Oxcarbazepine
- Pentobarbital
- Phenobarbital
- Phenytoin
- Prednisone
- Primidone
- Rifabutin
- Rifampin
- Rifapentine
- Secobarbital
- St John's Wort
- Thiopental
How much does Osphena (ospemifene) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Osphena (brand)
$205.20
Osphena (ospemifene) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Osphena (ospemifene) will not be safe for you to take.
- Abnormal vaginal bleeding
- Estrogen-dependent cancers or tumors
- Currently have or have had a blood clot (deep vein thrombosis or pulmonary embolism)
- Currently have or have had a stroke or heart attack
- Currently pregnant or can become pregnant
What are alternatives to Osphena (ospemifene)?
There are a number of medications that your doctor can prescribe in place of Osphena (ospemifene). Compare a few possible alternatives below.
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Osphena (ospemifene) images
