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Osphena

Osphena Side Effects

Cydnee Ng, PharmDMichelle Nguyen, PharmD
Reviewed by Cydnee Ng, PharmD, Michelle Nguyen, PharmD
Last reviewed on July 8, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Hot flashes (12%)
  • Vaginal discharge (6%)
  • Muscle spasms (5%)

Less Common Side Effects

  • Headaches
  • Excessive sweating
  • Vaginal bleeding
  • Night sweats

Osphena serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood clot in arm or leg: swelling, pain, or tenderness in the arm or leg; skin that's warm to the touch
  • Blood clot in the lung: trouble breathing, chest pain
  • Heart attack: chest pain, arm pain, shortness of breath, cold sweat, lightheadedness
  • Stroke: sudden weakness on one side of the body, drooping face, changes in your speech or vision, confusion, bad headache
  • Abnormal vaginal bleeding that doesn't go away or keeps happening

Source: DailyMed

The following Osphena side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Vaginal bleeding

Incidence not known

Anxiety

change in vaginal discharge

chest pain

cough

dizziness or lightheadedness

fainting

fast heartbeat

fever

hives, itching, skin rash

hoarseness

irritation

joint pain, stiffness, or swelling

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

pain or feeling of pressure in the pelvis

pain, redness, or swelling in the arm or leg

redness of the skin

swelling of the eyelids, face, lips, hands, or feet

tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area

tightness in the chest

troubled breathing or swallowing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Feeling of warmth

redness of the face, neck, arms, and occasionally, upper chest

sudden sweating

white or brownish vaginal discharge

Less common

Headache

increased sweating

muscle spasms

night sweats

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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