Onexton is a topical gel that contains clindamycin 1.2% (a lincosamide antibiotic) and benzoyl peroxide 3.75% (an antiseptic). It's applied to the face once per day to treat acne in people ages 12 years and older. Side effects include skin redness and scaling. Onexton (clindamycin / benzoyl peroxide) is only available as a brand name medication.
Treatment of acne on the face in people ages 12 years and older
Onexton (clindamycin / benzoyl peroxide) is a combination of two medications that work together to treat acne.
Clindamycin is a lincosamide antibiotic. It works by stopping bacteria from making their own proteins. This prevents the bacteria that cause acne from growing and spreading.
Benzoyl peroxide is an antiseptic. It works by killing the bacteria on the skin that cause acne. It also helps improve the skin texture by shedding damaged or flaking skin and reducing inflammation.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
A first-choice option for treating acne
Combines two medications into a single product
Applied once per day
Take weeks to months to notice improvement
Can make your skin more sensitive to light
Although rare, clindamycin in Onexton can cause inflammation in the colon
Clean the affected area(s) of your face with a mild cleanser and rinse with warm water before applying Onexton (clindamycin / benzoyl peroxide). Pat the skin completely dry before using Onexton (clindamycin / benzoyl peroxide).
Apply a thin layer of Onexton (clindamycin / benzoyl peroxide) on the affected area(s) of the skin on the face once a day. Make sure to apply just enough to cover the skin with a thin layer of medication.
Wash your hands after using Onexton (clindamycin / benzoyl peroxide). Avoid touching your eyes, lips, or areas of skin that are broken until after you've cleaned your hands. Getting the medication on these sensitive areas can cause skin irritation and pain.
Onexton (clindamycin / benzoyl peroxide) can cause dry and peeling skin. You can minimize skin irritation by applying oil-free moisturizer after applying Onexton (clindamycin / benzoyl peroxide).
Onexton (clindamycin / benzoyl peroxide) can make your skin more sensitve to the sun. You're recommended to apply sunscreen and wear protective clothing (e.g., hats) when going outside to help protect against sunburns.
Store Onexton (clindamycin / benzoyl peroxide) at room temperature (up to 77 degrees F) for up to 10 weeks. You'll need to discard the medication after 10 weeks, even if there's medication still left in the container.
Onexton (clindamycin / benzoyl peroxide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Applying Onexton (clindamycin / benzoyl peroxide) to mouth, eyes, or broken skin | Using Onexton (clindamycin / benzoyl peroxide) for a long time | Taking opioids or Lomotil (diphenoxylate / atropine) with Onexton (clindamycin / benzoyl peroxide)
Although rare, there have been reports of clindamycin getting absorbed from the skin and into the body, and causing a potentially life-threatening condition called colitis. Colitis is inflammation of your large intestine (the colon). People who take opioid pain medications (e.g., Norco (hydrocodone / acetaminophen), oxycodone, etc.) or Lomotil (diphenoxylate / atropine) might be at risk for prolonged or worsening colitis.
If you experience diarrhea that doesn't go away, especially if it's bloody and causes severe stomach cramps, stop using Onexton (clindamycin / benzoyl peroxide) and seek medical help. In some people, these symptoms might not happen until a few weeks after stopping the medication.
Your skin can become more sensitive to ultraviolet (UV) light while using Onexton (clindamycin / benzoyl peroxide). Too much exposure to UV light can even cause severe sunburn. Minimize your exposure to sunlight, sun lamps, and tanning beds during and immediately following treatment with Onexton (clindamycin / benzoyl peroxide). If possible, limit your time out in the sun or seek shade when you're outside. If you plan on spending time in the sun, ask your dermatologist about using sunscreen and wearing protective clothing (e.g., hats, long-sleeved shirts).
Using other topical acne medications along with Onexton (clindamycin / benzoyl peroxide) can cause skin irritation, such as peeling and flakey skin. If this happens, your dermatologist might ask you to temporarily stop treatment or use the medications less often until the skin irritation gets better. But if you experience severe skin irritation, your dermatologist will likely ask you to stop treatment and consider other options.
Dosage | Quantity | Price as low as | Price per unit |
---|---|---|---|
50g of 1.2%/3.75% | 1 pump | $712.01 | $712.01 |
Onexton contains 1.2% of clindamycin and 3.75% of benzoyl peroxide.
Clean the affected areas with a mild cleanser and warm water and pat the skin dry. Then, apply a pea-sized amount into a thin layer over the affected area(s) on your face once per day.
Allergy lincomycin
History of certain inflammatory gut problems (e.g., ulcerative colitis, antibiotic-associated colitis, or regional enteritis)
Treatment of acne on the face in people ages 12 years and older
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