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Hydrocodone/Acetaminophen Coupon - Hydrocodone/Acetaminophen 5mg/325mg tablet

hydrocodone / acetaminophen

Generic Norco
Used for Pain

Norco is a combination medication that contains hydrocodone (an opioid) and acetaminophen (an analgesic). It's used to manage pain for people who've tried non-opioid medications but haven't gotten enough relief. Norco (hydrocodone / acetaminophen) is a tablet that's taken by mouth. It takes about 30 minutes to start working. Side effects include constipation, nausea, and sleepiness. It's also a controlled substance because it has a high risk of misuse and dependency.

Please note: The brand name Norco is no longer available in the United States, but there are generic hydrocodone/acetaminophen tablets on the market.

Reviewed by:Last reviewed on April 5, 2024
basics-icon

What is Norco (hydrocodone / acetaminophen)?

What is Norco (hydrocodone / acetaminophen) used for?

  • Pain that isn't relieved by non-opioid pain medications alone

How Norco (hydrocodone / acetaminophen) works

Norco (hydrocodone / acetaminophen) is a combination of two medications that work together to treat pain.

  • Hydrocodone is an opioid. It attaches to certain mu-opioid receptors in your brain to lower how much pain you feel.
  • Acetaminophen is an analgesic. It blocks the production of certain chemicals in your brain that play a role in pain. As a result, acetaminophen helps relieve pain.
When does Norco (hydrocodone / acetaminophen) start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsNorco(brand name no longer available)
Drug ClassOpioid / Analgesic
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityPrescription only
warnings-icon

Risks and warnings for Norco (hydrocodone / acetaminophen)

Norco (hydrocodone / acetaminophen) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Potential for misuse and addiction

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health conditions

Black Box Warning Norco (hydrocodone / acetaminophen) is a controlled substance that has a risk for misuse and addiction. Take the medication exactly as prescribed. Don't change the dose or how often you take it without talking to your prescriber first.

blank warning iconMisusing Norco (hydrocodone / acetaminophen) might cause the medication to work less well. It can also raise the risk for serious and possibly life-threatening side effects, such as dangerously slow breathing, not able to stay awake, addiction, and opioid overdose. You'll be prescribed the lowest amount of Norco (hydrocodone / acetaminophen) that's necessary to manage your pain for the shortest period of time possible.

blank warning iconBecause of the risk for misuse, addiction, and overdose, Norco (hydrocodone / acetaminophen) is only available through a Risk Evaluation and Mitigation Strategy (REMS) program called the Opioid Analgesic REMS program. Your prescriber and pharmacy must register with the program, receive training on proper medication use, and discuss with you about how to safely use Norco (hydrocodone / acetaminophen).

Dangerously slow breathing (respiratory depression)

  • Risk factors: Taking medications that can cause slow breathing | Drinking alcohol | Older age | Being frail | Medical conditions that cause breathing problems (e.g., COPD, asthma, head injury) | Taking too much Norco (hydrocodone / acetaminophen)

Black Box WarningNorco (hydrocodone / acetaminophen) can cause dangerously slow breathing, which can be life-threatening. This can happen to anyone and at recommended doses. But the risk is greatest when you first start treatment or when your dose goes up.

blank warning iconDon't drink alcohol while you're taking Norco (hydrocodone / acetaminophen). And don't take the opioid medication with other medications that slow your body down (e.g., benzodiazepines, other opioids, muscle relaxants). Doing so raises your risk of extremely slowed breathing.

blank warning iconYour prescriber might write a prescription for naloxone (Narcan), a medication that can reverse slowed breathing from opioids. Your prescriber will instruct you to carry it with you at all times. Use naloxone, call 911, and get medical help right away if you or your loved one notices that you have trouble breathing or have bluish-colored lips, fingers, or toes.

Risk for opioid overdose

  • Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of Norco (hydrocodone / acetaminophen) | Taking more opioids than prescribed | Alcohol use

Black Box WarningTake Norco (hydrocodone / acetaminophen) exactly as prescribed. Taking too much medication or taking it more often than prescribed can lead to an overdose. It can be very dangerous if someone accidentally swallows the medication. Be sure to keep the opioid medication out of reach from children, pets, or visitors to prevent accidental exposure or overdose.

blank warning iconSymptoms of an opioid overdose include not responding to sound or touch, extremely slowed breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will probably write a prescription for naloxone (Narcan), a medication that can treat an opioid overdose. Carry naloxone with you at all times; use it and call 911 right away if an overdose happens.

Difficulty concentrating and extreme sleepiness

  • Risk factors: Taking high doses of Norco (hydrocodone / acetaminophen) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness

Black Box WarningNorco (hydrocodone / acetaminophen) can cause extreme sleepiness and lower your ability to think, react, and focus. Don't drink alcohol or take other medications that can cause sleepiness or "brain fog" (e.g., benzodiazepines, muscle relaxants, sleep medications) with Norco (hydrocodone / acetaminophen). Doing so can worsen these side effects.

Make sure you know how Norco (hydrocodone / acetaminophen) affects you before driving a car or doing activities that require your concentration. Talk to a healthcare professional (HCP) if you feel too sleepy from the medication.

Liver damage

  • Risk factors: Drinking alcohol | Taking other medications containing acetaminophen | Taking too much Norco (hydrocodone / acetaminophen) | History of liver problems

Black Box WarningNorco (hydrocodone / acetaminophen) contains acetaminophen. Taking too much acetaminophen can cause liver damage that can be life-threatening. The risk for liver damage is higher if you're taking more than one medication that contains acetaminophen, if you already have liver problems, or if you regularly drink alcohol.

blank warning iconLet your prescriber know about your medical history, especially if you have liver problems, before you take Norco (hydrocodone / acetaminophen). Also avoid drinking alcohol while you're taking this medication. Your prescriber can discuss how much acetaminophen you can take per day depending on your age and your risk for liver damage.

blank warning iconCall an HCP right away if you notice any symptoms of liver damage. These symptoms can include tiredness, dark urine, upset stomach, stomach pain, or yellowing of the skin or whites of the eyes.

Drug interactions

Black Box WarningNorco (hydrocodone / acetaminophen) interacts with a lot of common medications. So it's important to tell your prescriber and pharmacist about the medications you're taking and planning to take with Norco (hydrocodone / acetaminophen). Your care team can check that your medications are safe to take together. Also talk to your care team first before making any changes to your medications because sudden dose adjustments can also lead to harm.

blank iconSome interactions can raise the level of Norco (hydrocodone / acetaminophen) in your body. This can raise your risk for serious side effects, including potentially life-threatening slowed breathing. Examples of medications that can lead to this type of interaction with Norco (hydrocodone / acetaminophen) include erythromycin, ketoconazole, and ritonavir (Norvir).

blank iconOther drug interactions can lower the levels of Norco (hydrocodone / acetaminophen) in your body. This can cause the opioid medication to work less well for pain and possibly lead to withdrawal symptoms. These interactions include taking Norco (hydrocodone / acetaminophen) with rifampin (Rifadin) or carbamazepine (Tegretol).

Harm to newborn babies

Black Box Warning Long-term use of Norco (hydrocodone / acetaminophen) during pregnancy can cause your unborn baby to become dependent on the medication. This is because the opioid in the medication (hydrocodone) can pass through the placenta to your unborn baby.

Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding behavior, trembling, abnormal sleep patterns, and seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your HCP know if you've used Norco (hydrocodone / acetaminophen) during pregnancy or if you notice these symptoms in your baby.

Severe allergic reactions and skin reactions

  • Risk factors: Allergy to other opioids

Severe allergic reactions to Norco (hydrocodone / acetaminophen) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (e.g., closing of the throat). Additionally, acetaminophen can rarely cause serious skin reactions, such as rash, blisters, skin reddening, or skin peeling. Get medical attention right away if you notice these types of changes in your skin, swelling of the lips or tongue, or difficulty breathing after you take this medication.

Physical dependence and withdrawal

  • Risk factors: Long-term use of Norco (hydrocodone / acetaminophen)

Norco (hydrocodone / acetaminophen) can cause physical dependence when it's taken for a long period of time. This means that your body starts to rely on the medication to function. You might experience withdrawal if you suddenly stop taking the medication or lower your dose too fast. Withdrawal symptoms can be bothersome and include anxiety, restlessness, irritability, runny nose, sweating, and chills.

Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Your prescriber will slowly lower your dose to prevent withdrawal symptoms. Talk to your prescriber about alternative pain medications if you have concerns about the risk for dependence and withdrawal with Norco (hydrocodone / acetaminophen).

Low blood pressure

Norco (hydrocodone / acetaminophen) can cause extremely low blood pressure. Your blood pressure might drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to your HCP if any dizziness or lightheadedness doesn't go away.

Low adrenal hormone levels

  • Risk factors: Taking Norco (hydrocodone / acetaminophen) for longer than 1 month

Some people taking opioid medications like Norco (hydrocodone / acetaminophen) have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month. Symptoms include tiredness, dizziness, weakness, not feeling hungry, nausea, and vomiting. Tell your HCP if you have these symptoms. If your adrenal hormone levels are too low, you might need to stop Norco (hydrocodone / acetaminophen) and be treated with corticosteroids.

Seizures

  • Risk factors: History of seizure conditions

Opioids such as hydrocodone can raise the risk of having seizures more often in people who've had one before. Norco (hydrocodone / acetaminophen) can also raise your risk of seizures in certain situations. Get medical help right away if you have a seizure while you're taking this medication.

side-effects-icon

Side effects of Norco (hydrocodone / acetaminophen)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness
  • Sleepiness
  • Nausea
  • Vomiting
  • Constipation
  • Itching

Less Common Side Effects

  • Headache
  • Tiredness
  • "Brain fog"
  • Stomach pain
  • Changes in blood pressure

Norco (hydrocodone / acetaminophen) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
  • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, cold or clammy skin, slow heartbeat, upper right-sided stomach pain, dark urine, yellowing of your skin or eyes
  • Opioid withdrawal: anxiety, suicidal thoughts, restlessness, runny nose, yawning, sweating, chills, wide pupils, irritability
  • Serious allergic reaction or skin reaction: rash, hives, blistering or peeling skin, shortness of breath, fast heartbeat, dizziness, feeling warm suddenly
When do Norco (hydrocodone / acetaminophen) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Sleepiness
"Brain fog"
Nausea or vomiting
Constipation
Risk for slowed breathing
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Norco (hydrocodone / acetaminophen) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Dizziness

lightheadedness

Incidence not known

Back, leg, or stomach pains

black, tarry stools

bleeding gums

blood in the urine or stools

blood in vomit

bluish lips or skin

chills

choking

cough

dark urine

decrease in the frequency of urination

decrease in urine volume

difficult or trouble breathing

difficulty in passing urine (dribbling)

difficulty with swallowing

fast heartbeat

fever

fever with or without chills

general body swelling

general feeling of tiredness or weakness

headache

hoarseness

irregular, fast or slow, or shallow breathing

light-colored stools

loss of appetite

lower back or side pain

nausea

nosebleeds

not breathing

painful or difficult urination

pale or blue lips, fingernails, or skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe or continuing stomach pain

skin rash, hives, or itching

sore throat

sore tongue

sores, ulcers, or white spots on the lips or in the mouth

tightness in the chest

unable to speak

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

vomiting

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Bloody or cloudy urine

change in consciousness

chest pain or discomfort

cold and clammy skin

decreased awareness or responsiveness

extreme drowsiness

general feeling of discomfort or illness

increased sweating

irregular heartbeat

lightheadedness, dizziness, or fainting

loss of consciousness

no blood pressure or pulse

no muscle tone or movement

not breathing

severe sleepiness

slow or irregular heartbeat

stopping of heart

sudden decrease in the amount of urine

unpleasant breath odor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Drowsiness

relaxed and calm feeling

sleepiness

Incidence not known

Belching

changes in mood

difficulty having a bowel movement

fear or nervousness

feeling of indigestion

hearing loss

impaired hearing

pain in the chest below the breastbone

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Avg retail price
$16.21(Save 53.67%)
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$7.51
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pros-and-cons-icon

Pros and cons of Norco (hydrocodone / acetaminophen)

Pros

  • Can provide pain relief within 30 minutes
  • Available as a lower-cost, generic medication

Cons

  • Can be habit-forming
  • Not recommended to take with other medications containing acetaminophen since it can raise the risk of liver damage
  • Is a controlled medication, so there are special requirements to get a prescription filled
pharmacist-tips-icon

Pharmacist tips for Norco (hydrocodone / acetaminophen)

pharmacist
  • It's common to have constipation as a side effect of Norco (hydrocodone / acetaminophen). Drink enough water each day and add more foods with fiber to your diet. Speak to your care team if these lifestyle changes aren't enough to help with this side effect. They can recommend medications or a change in your pain treatment.
  • Don't drink alcohol while you're taking Norco (hydrocodone / acetaminophen). Mixing them together can make you very sleepy or dizzy and unable to think clearly. It can also harm your liver.
  • Take Norco (hydrocodone / acetaminophen) exactly as your prescriber instructed you to. Don't change your dose or stop taking the medication without talking to your prescriber first. Your prescriber might lower your dose slowly over a period of time before you can completely stop the medication. This lowers your risk for bothersome withdrawal symptoms like muscle aches, chills, and trouble sleeping.
  • Make sure to always have naloxone (Narcan) with you. Naloxone is a medication that's used to help reverse the effects of Norco (hydrocodone / acetaminophen) in situations like an accidental overdose. Teach your loved ones about how to give naloxone to you if you can't do it yourself. Be sure to call for emergency help if you need to use naloxone because its effects are temporary.
  • Let your prescriber know if you're pregnant before you start taking Norco (hydrocodone / acetaminophen) or if you become pregnant while you're taking this medication. Norco (hydrocodone / acetaminophen) isn't recommended during pregnancy.
  • Tell your healthcare team if you're breastfeeding. It's typically recommended to avoid Norco (hydrocodone / acetaminophen) because the opioid medication can get into breast milk. This raises the risk for serious side effects to your baby (e.g., sleepiness, slowed breathing).
  • Keep Norco (hydrocodone / acetaminophen) out of reach from children, pets, or visitors. There are a few drug take-back options to safely get rid of the medication if you don't need to take it anymore. This lessens the risk for accidental overdose and medication misuse.
dosage-icon

Norco (hydrocodone / acetaminophen) dosage

The average cost for 90 tablets of 5mg/325mg of Norco (hydrocodone / acetaminophen) is $23.73 with a free GoodRx coupon. This is 73.66% off the average retail price of $90.08.
tabletTablet
DosageQuantityPrice as low asPrice per unit
10mg/325mg120 tablets$26.53$0.22
5mg/325mg90 tablets$23.73$0.26
7.5mg/325mg90 tablets$24.95$0.28
5mg/300mg30 tablets$16.92$0.56
7.5mg/300mg90 tablets$29.14$0.32
10mg/300mg90 tablets$33.75$0.38
2.5mg/325mg60 tablets$26.37$0.44

Typical dosage for Norco (hydrocodone / acetaminophen)

Your prescriber will work with you to find the right dose of Norco (hydrocodone / acetaminophen) for your individual needs. It's recommended to use the lowest dose possible for the shortest duration of time to manage your pain.

The typical starting dose is 5 mg/325 mg (hydrocodone/acetaminophen) by mouth every 4 to 6 hours as needed for pain.

Keep in mind that this medication is available in different strengths — the tablets can contain different amounts of hydrocodone and acetaminophen in them. Make sure you know which strength you're using and how to take it properly. Ask your prescriber or pharmacist if you have any questions about your dose.

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Norco (hydrocodone / acetaminophen) reviews

GoodRx has partnered with to provide reviews on the different aspects of Norco (hydrocodone / acetaminophen).

Effectiveness

Learn more about the effectiveness of Norco (hydrocodone / acetaminophen) based on real life experiences.

Overall Rating

Based on 392 people taking this medication

3.6

Effectiveness by condition:

fibromyalgia339 reviews

3.5

rheumatoid arthritis19 reviews

3.4

degenerative disc disease14 reviews

3.5

osteoarthritis10 reviews

4.0

chronic pain syndrome10 reviews

3.8

Side effects
Learn more about the side effects others have reported while taking Norco (hydrocodone / acetaminophen).

Severity of side effects

Based on 1272 people taking this medication

None

39%

Mild

38%

Moderate

19%

Severe

6%

0%

50%

100%

Top side effects

Based on 1272 people taking this medication

Constipation

14%

Drowsiness

5%

Nausea

5%

Sleepiness

4%

Itching

3%

Usage
Review why people stop taking this medication and how long they take it.

Reasons people stopped taking Norco (hydrocodone / acetaminophen)

Based on 1180 people who have taken this medication

Other

25%

Did not seem to work

22%

Doctor's advice

21%

Course of treatment ended

16%

Side effects too severe

11%

Personal research

4%

Change in health plan coverage

3%

Expense

2%

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interactions-icon

Interactions between Norco (hydrocodone / acetaminophen) and other drugs

Norco (hydrocodone / acetaminophen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Norco (hydrocodone / acetaminophen). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Norco (hydrocodone / acetaminophen) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Norco (hydrocodone / acetaminophen) (generic)
GoodRx lowest price

$7.51

(save 92.03%)
contraindications-icon

Norco (hydrocodone / acetaminophen) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Norco (hydrocodone / acetaminophen) will not be safe for you to take.

  • Severely slowed breathing (respiratory depression)
  • Severe asthma
  • Medical conditions that cause blockage of the stomach passageway
  • Allergy to hydrocodone or acetaminophen
alternatives-icon

What are alternatives to Norco (hydrocodone / acetaminophen)?

There are a number of medications that your doctor can prescribe in place of Norco (hydrocodone / acetaminophen). Compare a few possible alternatives below.
Norco (hydrocodone / acetaminophen)
Used for:
  • Pain that isn't relieved by non-opioid pain medications alone
$7.51Lowest GoodRx priceView prices
Used for:
  • Mild pain
  • Fever
$5.04Lowest GoodRx priceView prices
Used for:

Over-the-counter ibuprofen:

Prescription ibuprofen:

$8.92Lowest GoodRx priceView prices
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News about Norco (hydrocodone / acetaminophen)

images-icon

Norco (hydrocodone / acetaminophen) images

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References

Best studies we found

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