The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (up to 95%)
- Nausea (up to 53%)
- Vomiting (up to 46%)
- Tiredness (up to 45%)
- Stomach pain (up to 36%)
- Lower appetite (up to 35%)
- Constipation (up to 31%)
- Weight loss (up to 20%)
- Rash (up to 18%)
- Redness, pain, or swelling inside of the mouth (up to 14%)
- Dizziness (up to 14%)
*These side effects happened when Nerlynx (neratinib) was taken by itself or together with other chemotherapy.
Less Common Side Effects
- Indigestion
- Swelling of the stomach area
- Muscle spasms
- Back or joint pain
- Symptoms of urinary tract infection (e.g., pain while urinating, needing to urinate more often)
- Infection of the sinuses or throat (upper respiratory tract infection)
- Nail changes
- Dry skin
- Dry mouth
Nerlynx serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe diarrhea
- Liver damage: yellowing of skin or whites of your eyes, dark-colored urine, right upper stomach pain or discomfort
Source: DailyMed
The following Nerlynx side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Severe or prolonged diarrhea
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Change in nail shape, thickness, or color
- Fatigue
- Loss of appetite with weight loss
- Muscle spasms
- Nausea
- Pain, redness, or swelling with sores inside the mouth or throat
- Stomach pain
