(dienogest / ethinyl valerate) monophasic
Basics, Side Effects, Reviews & More
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Natazia (estradiol valerate / dienogest) is a combined hormonal medication taken by mouth every day as a type of birth control to prevent pregnancy. It was specifically designed to improve the bleeding pattern and is also used to ease heavy menstrual bleeding. Compared to other birth control pills, it can be more complicated if you miss a dose.
Natazia
Estrogen / Progestin combined contraceptive
Not a controlled medication
No lower-cost generic available
Prescription only
Natazia (estradiol valerate / dienogest) is a combined contraceptive that contains two hormones: estradiol valerate (an estrogen) and dienogest (a progestin). Both hormones work together to prevent pregnancy by:
Natazia (estradiol valerate / dienogest) comes in a 28-day pack. There are 26 active tablets and they contain different dosages of dienogest and ethinyl valerate. There are also 2 placebo tablets and they don't contain any active medications.
The typical dose is 1 tablet by mouth at the same time every day. Tablets must be taken in the order instructed on the blister pack.
What is heavy menstrual bleeding?
You might have heavy menstrual bleeding if your period lasts for more than 7 days or if you're bleeding a lot during your period (needing to change your pad or tampon less than every 2 hours). If you have this type of bleeding, you should see your provider. Natazia (estradiol valerate / dienogest) can help treat heavy period bleeding by making periods more regular and reducing the amount of bleeding.
Why are there different colored pills in my pack of Natazia (estradiol valerate / dienogest)?
How should I start taking Natazia (estradiol valerate / dienogest)?
How well does Natazia (estradiol valerate / dienogest) work to prevent pregnancy?
Can Natazia (estradiol valerate / dienogest) make me feel nauseous?
First and only birth control pill FDA-approved to treat heavy periods
Only need to take once a day
Works very well to prevent pregnancy when taken as instructed
Available as a lower-cost generic
Tablets shouldn't be skipped or delayed by more than 12 hours
Must be taken in order as instructed on the blister pack
Can raise the risk for blood clotting problems
Not recommended during breastfeeding
Unknown if works well for females with a body mass index (BMI) greater than 30 kg/m2
Don't skip pills or delay taking your pill by more than 12 hours, or you could get pregnant. You can set an alarm to help yourself remember to take Natazia (estradiol valerate / dienogest) on time.
If you happen to miss your pill, refer to the patient instructions or call your provider. What you'll need to do will depend on how long it has been since you've missed your pill and where you are in your pack.
Hormonal contraceptives like Natazia (estradiol valerate / dienogest) don't protect against sexually transmitted diseases (STDs), such as chlamydia, gonorrhea, genital warts, or herpes. Using a latex or polyurethane condom during sex can help lower your risk of an STD.
Tell your provider if you're breastfeeding, since birth control pills that contain estrogen like Natazia (estradiol valerate / dienogest) can lower the amount of breast milk you make and can enter your breast milk. If you aren't breastfeeding, you can start this medication as soon as four weeks after your baby is born.
Natazia (estradiol valerate / dienogest) can cause some females to not have a period. However, if you miss two periods in a row or feel like you might be pregnant, call your provider.
Stop taking Natazia (estradiol valerate / dienogest) if you become pregnant. Studies haven't shown a risk of birth defects in females who took birth control pills before or during early pregnancy, but it's no longer necessary to take it.
It's common to experience breakthrough bleeding (spotting), especially during the first 3 months of taking Natazia (estradiol valerate / dienogest). Call your provider if you continue to have bleeding when you aren't on your period or if you start having spotting after you have had regular cycles.
If you develop new headaches that keep coming back, don't seem to go away, or if they're severe, contact your provider to discuss if Natazia (estradiol valerate / dienogest) might be causing them.
Natazia (estradiol valerate / dienogest) can interfere with many lab tests, so make sure to tell your provider you're taking it beforehand.
You can stop Natazia (estradiol valerate / dienogest) any time you'd like, but if you want to prevent pregnancy, speak with your provider about alternative birth control options.
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
Contact your doctor immediately if you experience any of the following:
The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time.
Source: DailyMed
Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
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Natazia (estradiol valerate / dienogest) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options
If you smoke cigarettes, using combined oral contraceptives (COCs), like Natazia (estradiol valerate / dienogest), raises your risk for serious health problems, such as strokes, heart attacks, and blood clots. Females age 35 years and older who smoke are at even higher risk for these problems. If you smoke, talk with your provider about safer birth control alternatives.
Natazia (estradiol valerate / dienogest) raises your risk of blood clots. These clots can occur anywhere in your body, including your lungs (pulmonary embolism or PE), legs (deep vein thrombosis or DVT), brain (stroke), and heart (heart attack). Get emergency help right away if you have any signs of a blood clot:
If you need to have surgery, tell your provider you're taking Natazia (estradiol valerate / dienogest). They might have you stop taking it 4 weeks before until 2 weeks after your surgery to lower your risk of blood clots.
Study results are mixed, but there's a possibility that Natazia (estradiol valerate / dienogest) and other COCs can raise your risk for breast and cervical cancer.
Don't use Natazia (estradiol valerate / dienogest) if you have breast cancer because some types of breast cancer grow faster in the presence of estrogen, an ingredient in this birth control pill. To help with early breast cancer detection, you can do monthly breast self-checks at home and yearly breast exams with your healthcare provider. Call your healthcare provider if you notice any abnormal changes or feel lumps, pain, or swelling in your breasts.
Get medical help right away if you experience abnormal vaginal bleeding, discharge, or pain during sex, since these could be signs of cervical cancer.
Though rare, Natazia (estradiol valerate / dienogest) can cause liver problems, such as liver damage and liver tumors. These problems are linked more with earlier formulations of COCs that contained higher levels of estrogen (50 mcg or higher). Call your provider right away if you experience symptoms of liver problems, such as tiredness, stomach pain, or yellowing of the skin or whites of the eyes.
Natazia (estradiol valerate / dienogest) and other COCs can raise your blood pressure. Your provider might ask you to check your blood pressure regularly. If you notice your blood pressure is higher while you're taking this medication, contact your provider. If you have uncontrolled high blood pressure, Natazia (estradiol valerate / dienogest) might not be the best option for you.
COCs like Natazia (estradiol valerate / dienogest) might raise your blood sugar and triglyceride (fat) levels. If you have diabetes, let your provider know if you experience any changes in your blood sugar. A rise in triglycerides can lead to serious conditions like inflammation of the pancreas (pancreatitis). Get emergency medical help if you notice symptoms of pancreatitis, which can include stomach pain, nausea, or vomiting.
Let your provider know if you experience symptoms of depression or worsening depression while taking Natazia (estradiol valerate / dienogest). In cases of serious depression, your provider might have you stop taking it.
Certain medications can make Natazia (estradiol valerate / dienogest) get broken down faster in your body, which can make Natazia (estradiol valerate / dienogest) work less well and lead to pregnancy. Some examples include carbamazepine (Tegretol), phenytoin (Dilantin), rifampicin, and St. John’s wort. You shouldn't take Natazia (estradiol valerate / dienogest) for at least 28 days after stopping any of these medications, since it might not work as well for you until after this time. Make sure to tell your provider or pharmacist all of your medications so they can make sure they don't interact with Natazia (estradiol valerate / dienogest).
If you have certain conditions, such as hereditary angioedema or chloasma (a skin condition that causes brown patches on the face), talk to your healthcare provider before taking Natazia (estradiol valerate / dienogest) because it might worsen your symptoms. If you have a history of chloasma, avoid exposure to the sun or UV light while taking COCs like Natazia (estradiol valerate / dienogest).
There is currently no generic for Natazia (estradiol valerate / dienogest), so it can be expensive, even with insurance. GoodRx coupons, copay cards and patient assistance programs may help lower the cost.
Pricing based on most commonly-filled versions: 1 packages of estradiol valerate/dienogest 28 tablets
There are a number of medications that your doctor can prescribe in place of Natazia (estradiol valerate / dienogest). Compare a few possible alternatives below.
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