Naprotin
Naprotin (naproxen / capsaicin) is a prepackaged kit with naproxen oral tablets and capsaicin topical cream. Together, these medications help to temporarily relieve aches and pains from certain conditions, such as different types of arthritis. The naproxen in Naprotin (naproxen / capsaicin) can interact with many medications, so always let your provider know what other medications you're taking, including over-the-counter products and supplements, before you start this kit.
What is Naprotin (naproxen / capsaicin)?
What is Naprotin (naproxen / capsaicin) used for?
To ease pain from:
- Tendonitis
- Bursitis
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Sprains and strains
- Minor pain in muscles and joints
How Naprotin (naproxen / capsaicin) works
Naprotin (naproxen / capsaicin) is a prepackaged kit with two different medications.
- Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking proteins from making chemicals called prostaglandins. Prostaglandins play many roles in your body, including causing pain and swelling where you get injured. By blocking your body from making prostaglandins, this medication eases joint pain and swelling.
- Capsaicin is a topical pain medication that's made from ingredients often found in chili peppers. It works by activating pain sensors in the skin, which then causes them to be less sensitive to other pain signals.
Drug facts
Side effects of Naprotin (naproxen / capsaicin)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Naproxen 500 mg tablet
In clinical trials, between 3% to 9% of people experienced the following side effects:
- Heartburn
- Belly pain
- Nausea
- Headache
- Dizziness
- Feeling drowsy
- Itching
- Bruising
- Ringing in the ear
- Swelling
- Trouble breathing
Penetral (capsaicin 0.025%) cream
- Burning
- Stinging
- Redness
- Itching
Less Common Side Effects
Naproxen 500 mg tablet
- Changes in vision
- Lightheadedness
- Constipation
- Diarrhea
- Indigestion
- Painful sores inside the mouth
- Sweating
- Palpitations
- Thirst
- Excess gas
- Unable to concentrate
Naprotin (naproxen / capsaicin) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart attack: trouble breathing, chest pain or tightness
- Stroke: blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
- Stomach bleeds: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn't go away
- Heart failure: trouble breathing, tiredness, swelling in your body, sudden weight gain
- Severe asthma attack: chest pain, cough, difficulty breathing, wheezing
- Serious allergic or skin reaction: fever, body aches, cough, peeling skin, rash, trouble breathing, swelling of the face, painful blisters all over your body
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Pros and cons of Naprotin (naproxen / capsaicin)
Pros
- Combines two medications into one kit for convenience
- Capsaicin cream can be applied directly to the painful area
- Naproxen works well for pain and inflammation
Cons
- Capsaicin cream can sometimes cause a skin reaction where applied
- Needs to be taken or applied multiple times a day
- Not recommended during pregnancy, particularly during the 2nd and 3rd trimester
Pharmacist tips for Naprotin (naproxen / capsaicin)
- How to use Penetral (capsaicin) cream: 1) Rotate the pump's spout counter-clockwise slightly to unlock the medication; 2) Apply the capsaicin cream sparingly (small amount) to the affected area; 3) Gently massage the medication into your skin until it's fully absorbed; 4) Wash your hands with soap and water.
- Penetral (capsaicin) cream in Naprotin (naproxen / capsaicin) should only be used on the outside of your body (i.e., skin) on skin that's not broken. You shouldn’t use it on wounds or on damaged skin. Don't use the cream on your face or take it by mouth. Never use it in your eyes, nose, or ears to avoid side effects.
- Don't cover the treated area with a bandage or heating pad after applying Penetral (capsaicin) cream. This can accidentally burn your skin and cause blisters.
- Avoid taking a shower or bath for at least an hour before or after applying Penetral (capsaicin) cream. Don't expose the treated area(s) to heat, such as sunbathing or using a tanning bed. The capsaicin in Naprotin (naproxen / capsaicin) can cause your skin to burn.
- Wash your hands before and after using Penetral (capsaicin) cream to help prevent getting the medication in your eyes or mouth. If it does get into your eyes, wash your eyes with water or saline and contact your provider if irritation lasts more than an hour.
- Stop using Penetral (capsaicin) cream and let your provider know immediately if you experience burning, pain, swelling, or blistering. These can be signs and symptoms of a serious skin burn from capsaicin.
- Store Penetral (capsaicin) cream at room temperature away from open flame since the cream can easily catch on fire.
- Make sure to take naproxen tablets with food since it can damage your stomach, causing belly pain, bleeding, or irritation.
- If you have a history of liver or kidney problems, high blood pressure, heart problems, asthma, or other medical conditions, ask your provider if it's safe for you to take Naprotin (naproxen / capsaicin). This is because naproxen tablets can sometimes worsen these medical conditions.
- Avoid using Naprotin (naproxen / capsaicin) if you're pregnant or plan to become pregnant. This is because naproxen tablets can cause harm to your unborn baby. If you need medication to help with pain, ask your provider about safer alternatives during pregnancy.
- Naprotin (naproxen / capsaicin) should be stored up and away and out of children's reach and sight. This prevents them from accidentally swallowing medication that's left out. Always put medication away every time you use it. If you think that your child might’ve accidentally swallowed Naprotin (naproxen / capsaicin), call your Poison Control Center at 1-800-222-1222 right away even if you aren't completely sure.
- Let your provider or pharmacist know what medications you're taking, including over-the-counter products and supplements, before you start Naprotin (naproxen / capsaicin). They can help you screen for interactions. Naproxen is very similar to ibuprofen (Advil), which is available OTC. If you take both medications at the same time, you're at higher risk for side effects, such as stomach bleeds.
Common questions about Naprotin (naproxen / capsaicin)
Animal studies suggest that taking naproxen could make it more difficult for females to become pregnant. And some small human studies suggest that this medication can delay your ovulation. But these studies also show that this effect is reversible once you stop taking naproxen. If you plan to have children, please talk with your provider about the benefits and risks of taking this medication.
If you're over age 65 years old, ask your provider whether Naprotin (naproxen / capsaicin) is a good choice for you. In general, it's best to not use naproxen in Naprotin (naproxen / capsaicin) if you're over 65 years of age. This is because naproxen can raise the risk of heart, kidney, or stomach problems, especially in older adults. If your provider prescribes Naprotin (naproxen / capsaicin) for you, make sure to use the lowest possible dose of naproxen for the shortest amount of time that works well for you.
If you're already taking aspirin, ask your provider whether or not it's safe to start Naprotin (naproxen / capsaicin). In general, don't take aspirin tablets with Naprotin (naproxen / capsaicin), unless your provider instructs you to do so. Both aspirin and naproxen are NSAIDs, which means using them together can put you at higher risk for side effects, such as stomach bleeds. If you're taking low-dose aspirin to prevent heart attack or stroke, consider using other pain medications, such as acetaminophen (Tylenol) or celecoxib (Celebrex), that don't interact with aspirin. If Naprotin (naproxen / capsaicin) alone isn't enough to treat your pain, discuss with your provider about other options for you.
If you've a history of heart problems, it's not recommended for you to take Naprotin (naproxen / capsaicin) unless your provider says it's safe for you to do so. This is because naproxen in Naprotin (naproxen / capsaicin) has been shown to raise the risk of serious (and sometimes life-threatening) heart problems, such as heart attacks. Additionally, naproxen can also cause more swelling, which can worsen heart failure. Please be aware that naproxen can interact with many common heart medications, such as ACE inhibitors or diuretics ("water pills), and cause them to not work as well. If you've severe heart failure or other heart problems, ask your provider about safe treatment options for your pain.
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Risks and warnings for Naprotin (naproxen / capsaicin)
Naprotin (naproxen / capsaicin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Heart attack and stroke
- Risk factors: History of heart problems| | Recent history of heart bypass surgery | High blood sugar | High cholesterol | Smoking | Taking high doses of naproxen | Taking naproxen for a long time
NSAIDs, like naproxen in Naprotin (naproxen / capsaicin), can raise your risk of having blood clots, heart attacks, or strokes. The risk might be higher if you have a history of heart problems, use this medication at higher doses, or use this medication for a long period of time. To prevent heart attack or stroke from happening, your provider will prescribe the lowest possible dose of Naprotin (naproxen / capsaicin) for the shortest amount of time that works well for you. If you have heart problems, talk to your healthcare provider before starting this medication. Don't use Naprotin (naproxen / capsaicin) if you've had or will be having heart bypass surgery. Call 911 or seek immediate medical help if you experience chest pain, trouble breathing, weakness on one side of your body, or trouble speaking or walking.
Stomach bleeding and ulcers
- Risk factors: Older adults | History of stomach bleeding or ulcers | Taking other medications that can cause stomach problems | Drinking alcohol | Smoking | Having poor health | Bleeding problems | Taking naproxen for a long time | Taking higher doses of naproxen
Naproxen in Naprotin (naproxen / capsaicin) can cause stomach bleeding and ulcers. These problems can occur without warning or symptoms, so it's best to use the lowest possible dose for the shortest possible time to minimize your risk. Some medications, such as oral corticosteroids and blood thinners, can raise your risk of stomach bleeding. Tell your provider about all the medications that you take before starting Naprotin (naproxen / capsaicin). If you have severe stomach pain, black and tarry stools, or blood in the urine while using this medication, get medical help promptly. Also, get medical help if you fall and hit your head or experience other injuries, your provider might want to examine you to make sure you're not bleeding on the inside.
If you experience bleeding, you're at risk for having low red blood cell count. Your provider will do blood tests to check your blood cell counts for these problems if you seem weaker than usual, have cold hands and feet, or trouble breathing.
Liver damage
- Risk factors: History of liver damage | Taking other medications that can cause liver damage
Though rare, naproxen can cause life-threatening liver damage. Your risk is higher if you use Naprotin (naproxen / capsaicin) with other medications that can also cause liver damage, such as acetaminophen (Tylenol). Liver damage can happen with or without symptoms, so it's best to use the lowest possible dose for the shortest possible time to minimize your risk. Your provider might order blood tests to check your liver function regularly. Stop Naprotin (naproxen / capsaicin) and talk to your provider right away if you experience symptoms such as fever, chills, fatigue, nausea, vomiting, yellowing of the skin or whites of the eyes, clay-colored stool, or dark urine.
High blood pressure, heart failure, and swelling of your arms and legs
- Risk factors: High blood pressure | Heart failure
NSAIDs, like naproxen in Naprotin (naproxen / capsaicin), can raise your blood pressure and can cause your body to hold onto more water. This can lead to new or worsen existing blood pressure problems, heart failure, and swelling of your arms and legs. Naprotin (naproxen / capsaicin) can also cause some blood pressure medications, such as furosemide (Lasix) and lisinopril (Zestril), to work less well. You're recommended to check your blood pressure regularly while using Naprotin (naproxen / capsaicin). Naprotin (naproxen / capsaicin) isn't recommended if you have heart failure, so discuss with your provider before starting this medication. Let your provider know right away if you notice any changes in your blood pressure or experience symptoms, such as trouble breathing, tiredness, swelling in your body, or sudden weight gain.
The swelling from fluids can also lower your red blood cell count (anemia). Let your provider know right away if you feel more weak or tired than usual, or if your hands and feet feel colder than what you're used to. They might need to check your blood cell counts.
Kidney damage
- Risk factors: Older adults | Kidney or liver problems | Heart failure | Taking certain high blood pressure medications | Loss of body fluid through conditions such as severe vomiting, bleeding, or diarrhea | Using naproxen for a long time
Naproxen in Naprotin (naproxen / capsaicin) can damage your kidneys by slowing down blood flow to the kidneys. The risk is higher if you're taking certain blood pressure medications (like ACE inhibitors or water pills) or have certain medical conditions (e.g., kidney problems, liver problems, heart failure). Kidney damage is usually reversible once you stop taking this medication. If you have very severe kidney problems, discuss the risks of using this medication with your provider.
Let your provider know if you experience chest pain, irregular heartbeat, muscle weakness, or nausea and vomiting. These are symptoms of high potassium levels caused by kidney problems. Let your provider know also if you notice a change in how often you urinate after starting Naprotin (naproxen / capsaicin).
Severe asthma attack and allergic reactions
- Risk factors: Asthma and stuffy nose with or without nasal polyps | History of allergic reaction to aspirin or other NSAIDs
Rarely, Naprotin (naproxen / capsaicin) can cause life-threatening allergic reactions. Naproxen in Naprotin (naproxen / capsaicin) can cause your airways to tighten, which might lead to severe asthma attacks. Be careful using this medication if you have asthma. People who've experienced asthma attacks triggered by aspirin or other NSAIDs in the past should avoid Naprotin (naproxen / capsaicin). Get medical help right away if your throat tightens and you can't breathe.
Serious skin reactions
Naproxen in Naprotin (naproxen / capsaicin) might cause sudden and serious skin reactions. Symptoms can include fever, body aches, rash, peeling skin, painful blisters all over your body, and swelling of the face. Stop Naprotin (naproxen / capsaicin) and get medical attention right away if you experience these symptoms.
Harm to unborn babies
- Risk factor: Currently in second or third trimester of pregnancy
Don't use Naprotin (naproxen / capsaicin), specifically naproxen, starting at 20 weeks of pregnancy. It can cause serious complications, such as heart or kidney problems in your unborn baby. If you're pregnant, speak to your provider about the risks and benefits of Naprotin (naproxen / capsaicin) and ask if there are safer alternatives.
Naprotin (naproxen / capsaicin) dosage
Kit| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 237ml/100 tablets of 0.025%/500mg | 1 kit | $2,814.25 | $2,814.25 |
Typical dosage for Naprotin (naproxen / capsaicin)
Each Naprotin (naproxen / capsaicin) kit consists of 2 separate ingredients:
Naproxen 500 mg tablet
- Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: The typical dose ranges from 250 mg to 500 mg by mouth twice daily. The maximum daily dose is 1500 mg for only up to 6 months.
- Tendonitis and bursitis: The typical dose is to take 500 mg by mouth once, then continue with 250 mg every 6 to 8 hours as needed. The maximum daily dose is 1250 mg.
Penetral (capsaicin 0.025%) cream
- The typical dose is to apply a small amount of cream to the affected area(s) up to 4 times daily.
How much does Naprotin (naproxen / capsaicin) cost?
$2,814.25
Naprotin (naproxen / capsaicin) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Naprotin (naproxen / capsaicin) will not be safe for you to take.
- History of asthma, hives or allergic reactions to naproxen or capsaicin (chili peppers)
- 10-14 days after a coronary artery bypass graft (CABG) surgery (a procedure to get rid of fat buildup in the arteries of the heart)
