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Mycozyl HC

tolnaftate / hydrocortisone
Used for Fungal Infection
Used for Fungal Infection

Mycozyl HC is a combination topical medication containing tolnaftate (an antifungal) and hydrocortisone (a topical corticosteroid). It's used to treat fungal skin infections that also involves itching, redness, and swelling. Mycozyl HC (tolnaftate / hydrocortisone) is available as a topical liquid and cream gel, and is applied to the skin twice daily. Typically, most people experience few to no side effects while using this medication as directed. But some people have reported skin burning, itching, and dry skin.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on July 17, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesPricesMedicare
basics-icon

What is Mycozyl HC (tolnaftate / hydrocortisone)?

What is Mycozyl HC (tolnaftate / hydrocortisone) used for?

  • Treatment and symptom relief of fungal skin infections (e.g., skin inflammation, itching)

How Mycozyl HC (tolnaftate / hydrocortisone) works

Mycozyl HC (tolnaftate / hydrocortisone) is a combination of two medications:

  • Tolnaftate is a topical antifungal medication. It works by blocking a protein that fungi need to grow. This stops the fungi from spreading and kills them.

  • Hydrocortisone is a topical corticosteroid. When it’s used on the skin, hydrocortisone lowers the amount of inflammatory chemicals that cause redness, itching, and swelling. This helps to decrease skin inflammation.

Are you looking for information on topical hydrocortisone or topical tolnaftate instead?

Drug Facts

Common BrandsMycozyl HC
Drug ClassAntifungal / Corticosteroid
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
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$802.25
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What are the side effects of Mycozyl HC (tolnaftate / hydrocortisone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Note: Side effects below were reported by people who used topical corticosteroids:
  • Skin burning
  • Itching
  • Skin irritation
  • Dry skin

Other Side Effects

  • Inflamed hair follicles
  • Acne-like bumps
  • Changes in skin color
  • Rash or heat rash
  • Thinning skin
  • Stretch marks
  • Pruning or wrinkling of the skin
  • Hair growth

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, itching, crusting, or peeling of treated skin
  • Fragile or thinning skin that bruises easily

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Change in skin color
  • Mild skin irritation, redness, or dryness
  • Small, red, pus-filled bumps on skin around hair follicles
  • Unexpected hair growth at application site
pros-and-cons

Pros and cons of Mycozyl HC (tolnaftate / hydrocortisone)

thumbs-up

Pros

Available as a topical liquid and gel

Combines two medications into one topical product for convenience

Can be stored at room temperature

thumbs-down

Cons

Short-term use only, otherwise it might cause skin thinning

Need to apply twice a day

Might not be a safe option during pregnancy

pharmacist-tips

Pharmacist tips for Mycozyl HC (tolnaftate / hydrocortisone)

pharmacist

  • Before applying Mycozyl HC (tolnaftate / hydrocortisone), wash your hands and clean the affected area(s) of your skin.

    • Use Mycozyl HC (tolnaftate / hydrocortisone) only on the outside of your body (e.g., skin). Don't swallow this medication, and never use it in your eyes, nose, or ears.

      • Wash your hands after using Mycozyl HC (tolnaftate / hydrocortisone) to help prevent getting the medication in your eyes. Rinse your eyes with water or saline if you accidentally get it in your eyes. Contact your primary care provider if the irritation doesn't go away.

        • Don't use Mycozyl HC (tolnaftate / hydrocortisone) on your face, underarms, or groin areas unless your primary care provider tells you to do so. The skin in these areas are more sensitive and side effects are more likely to happen.

          • If you're using other corticosteroid-containing products, check with your primary care provider first before using Mycozyl HC (tolnaftate / hydrocortisone). Using multiple corticosteroids can raise your risk of side effects.

            • Don't cover the treated area with a bandage after applying Mycozyl HC (tolnaftate / hydrocortisone) unless directed by your primary care provider. Don't use this medication on your child unless directed by a pediatrician. If you're applying this medication around the diaper area, don't use tight fitting diapers or plastic pants on your toddler. Doing so might affect how much medication gets absorbed.

              • For Mycozyl HC (tolnaftate / hydrocortisone) topical liquid: Use the brush applicator to apply the medication on the skin around the nails. Don't apply Mycozyl HC (tolnaftate / hydrocortisone) directly on your nails since this medication doesn't work well for nail fungal infections.

                • Store Mycozyl HC (tolnaftate / hydrocortisone) up and away and out of children's reach and sight. This prevents them from accidentally swallowing medicine that was left out. Always put medication away every time you use it. If you think that your child might’ve accidentally swallowed Mycozyl HC (tolnaftate / hydrocortisone), call your Poison Control Center at 1-800-222-1222 right away even if you aren't completely sure.

                  faqs

                  Frequently asked questions about Mycozyl HC (tolnaftate / hydrocortisone)

                  What fungal infection can Mycozyl HC (tolnaftate / hydrocortisone) be used for?
                  Mycozyl HC (tolnaftate / hydrocortisone) can be used for certain skin fungal infections, such as ringworm and athlete's foot. The tolnaftate can help fight the infection, and the hydrocortisone can help ease redness or itching that's caused by the infection. Your healthcare professional (HCP) will let you know if Mycozyl HC (tolnaftate / hydrocortisone) is appropriate for you.
                  How long does Mycozyl HC (tolnaftate / hydrocortisone) take to work?
                  Depending on your infection, you might feel some symptoms improve within 2 to 3 days of starting Mycozyl HC (tolnaftate / hydrocortisone). But it can take longer to treat the infection. Make sure to continue using Mycozyl HC (tolnaftate / hydrocortisone) for the entire treatment length that your primary care provider prescribed. This will help make sure that the infection is completely gone and help lower the risk of it coming back.
                  Can you put Mycozyl HC (tolnaftate / hydrocortisone) on your face?
                  Don't apply Mycozyl HC (tolnaftate / hydrocortisone) on your face unless directed by your primary care provider. This is because Mycozyl HC contains hydrocortisone, a topical corticosteroid. In general, you should avoid applying corticosteroid on sensitive skin areas, such as face. Doing so cna raise your risk of side effects, such as skin thinning or stretch marks.
                  Can you use Mycozyl HC (tolnaftate / hydrocortisone) while pregnant?
                  Talk with your obstetrician-gynecologist (OB-GYN) about the benefits and risks of using Mycozyl HC (tolnaftate / hydrocortisone) during pregnancy. Mycozyl HC contains a lower strength of hydrocortisone that's typically considered safe to used during pregnancy. But it's unclear whether tolnaftate is safe during pregnancy since it hasn't been well-studied in pregnant people.
                  What's the difference between Mycozyl HC (tolnaftate / hydrocortisone) and Lotrisone (clotrimazole / betamethasone)?
                  Both Mycozyl HC (tolnaftate / hydrocortisone) and Lotrisone (clotrimazole / betamethasone) are topical medications used to treat skin fungal infections. They both contain an antifungal medication and a topical steroid. Both medications are applied onto the skin twice daily. A big difference between the two medications is the strength of the topical steroid. Mycozyl HC contains a low-potency steroid (hydrocortisone 0.667%), whereas Lotrisone contains a moderate-to-high potency steroid (betamethasone). Ask your primary care provider about the pros and cons of each product to decide which one is the best choice for you.
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                  What are the risks and warnings for Mycozyl HC (tolnaftate / hydrocortisone)?

                  Mycozyl HC (tolnaftate / hydrocortisone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Use only on your skin

                  Mycozyl HC (tolnaftate / hydrocortisone) should only be used on your skin. Don’t put it in your eyes, nose, mouth, or ears. Call your Poison Control Center at 1-800-222-1222 right away if you think that your child might’ve accidentally swallowed or inhaled this medication.

                  risk-warning

                  Changes in hormone levels

                  • Risk factors: Using topical hydrocortisone for a long period of time | Using more Mycozyl HC (tolnaftate / hydrocortisone) than recommended | Covering applied area with a bandage

                    Using medications containing topical corticosteroids, like Mycozyl HC (tolnaftate / hydrocortisone), can cause your body to make less of its own stress hormones. This is more likely to happen if you use this medication for a longer period time or over larger areas of the body. And if you stop using Mycozyl HC (tolnaftate / hydrocortisone) all of a sudden, you might experience symptoms topical steroid withdrawal, such as red or itchy skin. This problem is usually temporary and your body's natural stress hormone level should return to normal over time. Let your healthcare team know if you're experiencing symptoms of low cortisol.

                    Using topical corticosteroids can also lead to symptoms of too much stress hormone, such as weight gain and high blood sugar levels. This is also more likely to happen for people who use topical corticosteroids over a longer period of time. Talk with your healthcare team if you're concerned about changes in hormone levels and how it might affect you.

                    risk-warning

                    High blood sugar levels

                    • Risk factors: Using Mycozyl HC (tolnaftate / hydrocortisone) for a long period of time | Using more Mycozyl HC (tolnaftate / hydrocortisone) than recommended

                      Using Mycozyl HC (tolnaftate / hydrocortisone) for a long period of time or over large areas of the body can sometimes raise your blood sugar levels. If your blood sugar level isn't controlled, this can lead to diabetes. When using Mycozyl HC (tolnaftate / hydrocortisone), your primary care provider might ask you to check your blood sugar level regularly to make sure this medication is safe for you. Let your primary care provider know if you feel more thirsty or are urinating more than usual.

                      risk-warning

                      New or worsened skin infection

                      • Risk factors: Using Mycozyl HC (tolnaftate / hydrocortisone) for more than 7 days

                        Using Mycozyl HC (tolnaftate / hydrocortisone) long term can raise the risk of other skin infections, such as bacterial infections. Let your primary care provider know if you have redness, swelling, pain, pus, or if your current symptoms don't improve after a few days of treatment. These can be signs and symptoms of a new infection.

                        risk-warning

                        Skin problems

                        • Risk factors: Excessive and inappropriate use of Mycozyl HC (tolnaftate / hydrocortisone) | Using a lot of Mycozyl HC (tolnaftate / hydrocortisone)

                          Using Mycozyl HC (tolnaftate / hydrocortisone) longer than directed by your primary care provider can raise your risk of different skin reactions, including skin thinning, stretch marks, spider veins, burning, itching, irritation, dry skin, inflamed hair follicles, changes in skin color, or rash. To prevent severe skin reactions from happening, your primary care provider will prescribe the lowest possible dose of Mycozyl HC (tolnaftate / hydrocortisone) to treat your symptoms for the shortest amount of time. Let your primary care provider know right away if you notice any new or worsening skin problems.

                          dosage

                          Mycozyl HC (tolnaftate / hydrocortisone) dosage forms

                          The average cost for 1 bottle of 30ml of 1%/0.667% of Mycozyl HC (tolnaftate / hydrocortisone) is $802.25 with a free GoodRx coupon.0
                          bottle of topical solution
                          Bottle of topical solution
                          DosageQuantityPrice as low asPrice per unit
                          30ml of 1%/0.667%1 bottle$802.25$802.25

                          Typical dosing for Mycozyl HC (tolnaftate / hydrocortisone)

                          Mycozyl HC (tolnaftate / hydrocortisone) is available as a topical liquid and gel. Both topical products contain 0.667% hydrocortisone and 1% tolnaftate.

                          • Adults: Apply a thin layer to the affected area(s) two times daily (morning and night), or as directed by your care team.

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                          How much does Mycozyl HC (tolnaftate / hydrocortisone) cost?

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                          Mycozyl HC (brand)
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                          $802.25

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                          alternatives

                          What are alternatives to Mycozyl HC (tolnaftate / hydrocortisone)?

                          There are a number of medications that your doctor can prescribe in place of Mycozyl HC (tolnaftate / hydrocortisone). Compare a few possible alternatives below.
                          Mycozyl HC (tolnaftate / hydrocortisone)
                          Used for:

                          • Treatment and symptom relief of fungal skin infections (e.g., skin inflammation, itching)

                          $802.25 Lowest GoodRx priceView Prices
                          Lotrisone (clotrimazole / betamethasone)
                          Used for:
                          $19.31 Lowest GoodRx priceView Prices
                          Clotrimazole (Lotrimin AF)
                          Used for:
                          $13.64 Lowest GoodRx priceView Prices

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