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Lonsurf

Lonsurf Dosage

Julia Lee, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on July 15, 2024

The average cost for 60 tablets of 20mg/8.19mg of Lonsurf is $19,289.74 with a free GoodRx coupon.

tabletTablet

Dosage

Quantity

Price as low as

Price per unit

15mg/6.14mg

40 tablets

$9,649.16

$241.23

20mg/8.19mg

60 tablets

$19,289.74

$321.50

Typical dosage for Lonsurf

Your treatment team will determine your dose based on your body surface area or body size (BSA, in m2 units), which they’ll calculate from your height and weight.

The typical dose is 35 mg/m2 of the trifluridine component of Lonsurf. The medication is available in two strengths: 15 mg of trifluridine with 6.14 mg of tipiracil; and 20 mg of trifluridine with 8.19 of tipiracil.

Each dose is taken by mouth twice a day with food on days 1 through 5 and days 8 through 12 of each 28-day treatment cycle. This means that you’ll take Lonsurf for 5 days in a row followed by 2 days of rest for the first 2 weeks of a cycle. Then, you’ll take 2 weeks off from the medication before you start the next cycle.

Your treatment team might adjust your Lonsurf dose based on how well your kidneys are working and whether you have side effects from the medication.

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