Letybo (letibotulinumtoxinA or letibotulinumtoxinA-wlbg) is an injection used for adults. It's FDA approved to temporarily improve frown lines between the eyebrows (glabellar lines). A trained professional gives Letybo as small injections into certain muscles near your eyebrows. Injections are given during a short office visit. You shouldn’t get them more often than every 3 months. Many people notice changes within days and full effects in about 2 weeks. Side effects include headache, droopy eyelid, and mild bruising or swelling at the injection site.
Letybo is a neuromuscular blocker. This means it blocks signals between your nerves and muscles. It works by stopping a nerve chemical called acetylcholine from being released from nerves. Acetylcholine normally tells your muscles to tighten.
When Letybo is injected near and between the eyebrows, it relaxes the muscles in that area. This helps soften frown lines. Over time, the effect wears off, usually within a few months.
| Common Brands | Letybo |
|---|---|
| Drug Class | Neuromuscular blocker |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Letybo can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Some people who use Letybo or similar products might have side effects that spread beyond the injection site. It can sometimes happen hours to weeks after treatment. These toxin effects can include trouble swallowing, speaking, or breathing. It can also include double vision or widespread weakness. This is rare but can be serious and life-threatening.
Let your prescriber know if you have any nerve or muscle conditions. Also tell them about any breathing or swallowing issues. You might be at higher risk and might need closer monitoring. Get urgent care if any of these symptoms happen after your Letybo treatment.
Severe allergic reactions to Letybo can happen. This can include anaphylaxis, hives, swelling, or trouble breathing. If this happens, stop treatment and get medical help right away. Tell your prescriber if you’ve had reactions to any botulinum toxin product in the past.
Heart issues, like abnormal heart rhythm and heart attack, have been reported with botulinum toxin use. Make sure to tell your care team if you have a history of heart problems. Get emergency help right away if you have chest pain, shortness of breath, an irregular heartbeat, or dizziness after treatment.
Trouble swallowing or breathing can happen hours to weeks after treatment with medications like Letybo. These problems might last for weeks to months. It mostly happens if the medication is injected into areas that affect breathing or swallowing. The risk might be higher if you already have problems with swallowing or breathing. It could also be higher if you have other conditions that affect your muscles or nerves.
Even though Letybo is injected near your eyebrows, it's still a good idea to know about this risk. Get medical help right away if you have trouble swallowing, speaking, or breathing.
Medications like Letybo can reduce tear production and blinking. This can cause dry eye, eye irritation, light sensitivity, and vision changes. Tell your care team if you notice these symptoms. You might need lubricating drops and to avoid driving until your vision clears.
Although rare, Letybo has a small risk of spreading certain viruses or diseases because it contains a protein from human blood. Blood donors are screened, the blood is tested for infections, and the product is processed to remove or kill viruses. These steps help lower the risk, but it’s still possible. If you have concerns, talk to your care team.
Letybo is an injection given into specific muscles near and between the eyebrows. It's given by a trained healthcare professional. Typically, you can receive treatment at most once every 3 months.
The recommended total dose is 20 Units per treatment session. This is given as five injections of 4 Units each into specific facial muscles.
The total amount of Letybo you can receive might differ if you also use other botulinum toxin products for other reasons. Your prescriber will consider the total toxin you’ve received recently to make sure it's safe for you.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Letybo will not be safe for you to take.
Temporarily improves the appearance of moderate to severe facial lines, including:
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In studies, some people saw their frown lines improve within 24 hours to a few days after getting Letybo. But it can take about 2 weeks to see the full effects. Keep in mind that everyone responds differently, so it might take more or less time for you to see results. Talk with your care team about what to expect after your Letybo treatment session.
The smoothing effects from Letybo can last around 4 months. Keep in mind that it isn't recommended to get treatment any sooner than at least 3 months from your last session. Otherwise, it could raise your risk of dangerous side effects. If you have questions, ask your care team about how long to expect effects to last with Letybo.
Letybo is manufactured by Hugel, Inc.
Letybo is a prescription medication. You can't buy it over the counter at a regular pharmacy. This medication must be given as an injection by a trained healthcare professional. To get Letybo, you need to visit a licensed healthcare professional, such as a board-certified dermatologist.
Letybo (letibotulinumtoxinA) and Daxxify (daxibotulinumtoxinA) are both injections used to smooth frown lines in adults. The main difference is how long they last and how they're designed. Daxxify typically lasts for about 6 months (and up to 9 months for some people). It's designed with a special "peptide technology" to help it last long. Letybo usually lasts for 3 to 4 months, which is common for this type of treatment. Daxxify might be a better choice if you want fewer office visits each year for maintenance. Talk to a dermatologist or other trained healthcare professional to compare these options.
If you're pregnant or breastfeeding, talk to a dermatologist or other cosmetic healthcare professional. There isn’t enough information to know if Letybo is safe in pregnancy or while nursing. The healthcare professional can weigh the risks and benefits with you. They can help you choose a safe option for you.
