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Lerochol
Used for High Cholesterol
Used for High Cholesterol
Lerochol (lerodalcibep) is a PCSK9 inhibitor used along with a healthy diet and regular exercise to help lower cholesterol in adults with high cholesterol. It comes as a prefilled syringe that’s injected under the skin once a month. Common side effects include injection site reactions and common cold symptoms.
What is Lerochol (lerodalcibep)?
What is Lerochol (lerodalcibep) used for?
- High cholesterol in adults, including heterozygous familial hypercholesterolemia (HeFH)
How Lerochol (lerodalcibep) works
Lerochol (lerodalcibep) is a PCSK9 inhibitor, meaning it blocks a protein called PCSK9. Normally, PCSK9 breaks down LDL receptors in your liver. These receptors remove LDL ("bad") cholesterol from your blood.
By blocking PCSK9, Lerochol (lerodalcibep) allows more of those receptors to stay active. This helps your liver remove more LDL cholesterol from your blood, lowering your cholesterol levels.
Drug facts
| Common Brands | Lerochol |
|---|---|
| Drug Class | PCSK9 inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Lerochol (lerodalcibep)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
High cholesterol levels
- Common cold symptoms (15%)
- Injection site reactions (12%)
HeFH
- Injection site reactions (18%)
- Common cold symptoms (13%)
Less Common Side Effects
High cholesterol levels
- Swelling in the arms and legs
HeFH
- Diarrhea
- Nausea
- Swelling in the arms and legs
The following Lerochol (lerodalcibep) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Nausea
- Pain, redness, or irritation at injection site
- Runny or stuffy nose
- Sore throat
- Swelling of the ankles, hands, or feet
Pros and cons of Lerochol (lerodalcibep)
Pros
- Once-monthly injection at home
- Works well to lower LDL cholesterol
- Can be used in adults with HeFH
Cons
- Injection site reactions are common
- Can cause nausea or diarrhea
- Long-term treatment is needed to keep LDL down
Pharmacist tips for Lerochol (lerodalcibep)
- Use Lerochol (lerodalcibep) on the same day every month. This helps keep your LDL cholesterol low. If you stop or delay doses often, your cholesterol can go back up.
- Continue eating a heart-healthy diet and exercising while taking Lerochol (lerodalcibep). These lifestyle changes help the medication work better.
- If you miss a dose of Lerochol (lerodalcibep), inject it as soon as you remember. If you're less than 7 days late, go back to your usual monthly schedule. If you're 7 or more days late, start a new monthly schedule from the day you inject your missed dose.
- Your prescriber will check your cholesterol while you're using Lerochol (lerodalcibep). This helps make sure the medication is working well enough for you.
- Pregnancy: Tell your prescriber right away if you become pregnant while using Lerochol (lerodalcibep) because this medication might harm an unborn baby.
- Breastfeeding: It isn’t known whether Lerochol (lerodalcibep) passes into human breast milk. Animal studies found the medication in milk, so your prescriber will help weigh the benefits of treatment against the possible risk to your baby while breastfeeding.
- Storage: Keep Lerochol (lerodalcibep) in the refrigerator in its original carton. You can also keep it at room temperature for up to 3 months, but don't freeze or shake it.
How to inject Lerochol (lerodalcibep):
- Let the syringe warm to room temperature for at least 30 minutes before you inject to make the shot more comfortable. Keep it in the original carton while it warms to protect it from light.
- Don’t inject it into skin that’s tender, bruised, red, or hard. And use a different injection site each month to help reduce redness, swelling, and soreness.
- Inject into the skin of your stomach or the front of your upper thigh. If someone else gives you the injection, they can also use the back of your upper arm.
- Pinch your skin and insert the needle at a 45° to 90° angle. Push the plunger all the way down until all of the medication has been injected.
- Throw away the used syringe in a sharps container right away. Safe needle disposal helps protect you, your family, and other people from needle sticks.
Lerochol (lerodalcibep) dosage
The average cost for 1 syringe of 1.2ml of 300 mg/1.2 mL of Lerochol (lerodalcibep) is $199.00 with a free GoodRx coupon.
Syringe
Syringe| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1.2ml of 300 mg/1.2 mL | 1 syringe | $199.00 | $199.00 |
Typical dosage for Lerochol (lerodalcibep)
Lerochol (lerodalcibep) is injected under the skin into your stomach or thigh. A caregiver or healthcare professional can also inject it into your upper arm.
The typical dose is 300 mg injected under the skin once a month.
How much does Lerochol (lerodalcibep) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Lerochol (brand)
$199.00
What are alternatives to Lerochol (lerodalcibep)?
There are a number of medications that your doctor can prescribe in place of Lerochol (lerodalcibep). Compare a few possible alternatives below.
News about Lerochol (lerodalcibep)
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