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Leqvio Coupon - Leqvio 1.5ml of 284mg/1.5ml syringe

Leqvio

inclisiran
Used for High Cholesterol
Used for High Cholesterol

Leqvio (inclisiran) is an injectable medication used to treat high cholesterol in adults. It's used together with a statin and with a heart-healthy diet. Leqvio (inclisiran) works as a small interfering RNA (siRNA) to help lower cholesterol. It's given as an injection under your skin and it must be given by a healthcare professional. After the first two starter doses, the injection is given twice a year. Side effects aren't common. But they can include joint pain and reactions at the injection site like pain and redness.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Cydnee Ng, PharmD
Last reviewed on July 18, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsDosageAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Leqvio (inclisiran)?

What is Leqvio (inclisiran) used for?

How Leqvio (inclisiran) works

Leqvio (inclisiran) belongs to the drug class called small interfering RNAs (siRNAs). Once injected, the medication gets absorbed into your liver. In the liver cells, the medication works to break down the gene that helps make a protein called PCSK9. Normally, PCSK9 helps adjust the amount of cholesterol in your body.

By breaking down this gene, Leqvio (inclisiran) stops your liver from making PCSK9. It helps your liver get rid of more "bad" cholesterol (LDL, or low-density lipoprotein) from your blood.

When does Leqvio (inclisiran) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsLeqvio
Drug ClasssiRNA
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Leqvio (inclisiran)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Joint pain
  • Bronchitis
When do Leqvio (inclisiran) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Injection site reactions

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Joint pain
  • Pain, redness, or irritation at injection site
pros-and-cons

Pros and cons of Leqvio (inclisiran)

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Pros

Helps lower "bad" cholesterol by about 50% when used with a statin

Given twice a year (after two starter doses)

Few side effects

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Cons

Must be given as an injection under the skin by a healthcare professional at their clinic

Must be used with statin therapy

Doesn't replace having a balanced diet and regular exercise plan to help lower cholesterol levels

pharmacist-tips

Pharmacist tips for Leqvio (inclisiran)

pharmacist

  • Write down your appointments for Leqvio (inclisiran) on your calendar. This will help you remember when to get your injections and not miss any doses.

    • If you miss an appointment by less than 3 months, call the medical office to reschedule and get Leqvio (inclisiran) as soon as possible. Afterwards, you can continue your usual dosing schedule. But if you miss your appointment by more than 3 months, you'll have to restart a new dosing schedule. This means taking the medication every 3 months for 2 doses, and then every 6 months after that.

      • During your appointment, a healthcare professional will give you your Leqvio (inclisiran) injection under your skin. They'll pick a spot on your stomach, upper arm, or thigh. They'll be careful not to give the injection where your skin is damaged to prevent irritation. This includes areas with sunburns, inflammation, infection, or rash.

        • Sometimes, the area where you got your Leqvio (inclisiran) injection can hurt or get red a few hours afterwards. These injection site reactions should go away on their own after a day or two. But in the meantime, you can use a cold pack to help. Tell your care team if these reactions get worse or don't go away after a couple days.

          • Be sure you get any blood work that your prescriber asks for while you're taking Leqvio (inclisiran). This helps them check your cholesterol levels. They want to make sure your treatment plan is working well for you.

            faqs

            Frequently asked questions about Leqvio (inclisiran)

            Is Leqvio (inclisiran) a statin?
            No, Leqvio (inclisiran) isn't a statin. Instead, it's a type of medication called a small interfering RNA (siRNA). Leqvio (inclisiran) and statins both help lower "bad" cholesterol (LDL, or low-density lipoprotein). But they work in different ways. Leqvio (inclisiran) helps your liver get rid of cholesterol from your blood. Statins work by stopping your liver from making cholesterol. Leqvio (inclisiran) is used together with a statin. This is helpful for people with cholesterol levels that are still high even with a statin.
            How long do Leqvio (inclisiran) side effects last?
            Injection site reactions, like pain or redness, are the most commonly reported side effect of Leqvio (inclisiran). If this happens, it usually only lasts for a day or two. Tell your care team if any reactions are the injection site don't get better after a couple days or if they get worse. Also let them know if you have any other side effects from the medication that bother you. They can check what's going on and help you.
            Does Leqvio (inclisiran) cause weight gain or weight loss?
            Leqvio (inclisiran) itself doesn't seem to make people gain or lose weight. But the medication is usually taken with a statin. A large study in 2014 found that people who took statins for a long time (about 10 years) gained some weight. This might've been caused by changes in their diet. It's important to remember to follow healthy habits to help lower cholesterol. This includes eating foods that are good for your heart and exercising regularly. It'll help you get the most out of your cholesterol treatment plan. What's more, it'll help you keep your weight healthy. If you notice your weight changing a lot, talk to your primary care provider.
            Can you take Leqvio (inclisiran) without a statin?
            Leqvio (inclisiran) is FDA approved to be taken with a statin to treat high cholesterol. But some studies show Leqvio (inclisiran) can also lower cholesterol even if you don't take it with a statin. Taking Leqvio (inclisiran) by itself might be an option for some people. This could be for people who have side effects from statins that bother them too much. It could also be for people who can't take statins for safety reasons. Talk to your prescriber to find out if taking Leqvio (inclisiran) without a statin is right for you.
            What's the difference between Leqvio and Repatha?
            Leqvio (inclisiran) and Repatha (evolocumab) are both medications that can treat high cholesterol when statins aren't enough. They both lower cholesterol by stopping a protein called PCSK9 from doing its job in the body. But they do this in different ways. Leqvio works by breaking down the gene that makes PCSK9 so that the body can't make as much of the protein. Repatha blocks the PCSK9 protein itself after it's already made. Both medications are injections given under the skin. You can give yourself Repatha injections at home every 2 or 4 weeks. But for Leqvio, a healthcare professional needs to give the injection every 3 months for the first 2 doses and then every 6 months after that. Talk to your prescriber to compare the medications and see which is best for you.
            How well does Leqvio (inclisiran) work to lower cholesterol?
            In studies, people's cholesterol levels went down by about 50% after about 3 months of taking Leqvio (inclisiran) with a statin. This 50% reduction generally stayed consistent as they took both medications together for about 1.5 years. Be sure to get your cholesterol tests done when your prescriber asks. This helps check how well treatment is working for you. Ask your prescriber if you have more questions about your progress.
            Can you take Leqvio (inclisiran) while pregnant?
            Leqvio (inclisiran) isn't recommended if you're pregnant. It isn't known if the medication is safe during pregnancy. Let your prescriber know if you're pregnant or thinking of getting pregnant. They can talk to you about your options if you need to manage your cholesterol.
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            dosage

            Leqvio (inclisiran) dosage forms

            Typical dosing for Leqvio (inclisiran)

            The medication is given as an injection under the skin by a healthcare professional. It's injected into your stomach, thigh, or upper arm.

            The typical dose is 284 mg injected under the skin every 3 months for 2 doses, then every 6 months after that.

            alternatives

            What are alternatives to Leqvio (inclisiran)?

            There are a number of medications that your doctor can prescribe in place of Leqvio (inclisiran). Compare a few possible alternatives below.
            Leqvio (inclisiran)
            Used for:
            View Prices
            Repatha (evolocumab)
            Used for:

            • High cholesterol in adults

            • Inherited condition causing extremely high cholesterol (heterozygous and homozygous familial hypercholesterolemia) in people aged 10 years and older

            • Lower the risk of heart attack, stroke, and the need for heart procedures (like stent placement) in adults with known heart disease

            $588.20 Lowest GoodRx priceView Prices
            Praluent (alirocumab)
            Used for:
            $527.68 Lowest GoodRx priceView Prices
            images

            Leqvio (inclisiran) images

            yellow - LEQVIO 284mg / 1.5mL Solution for Injection
            This medicine is Yellow Syringe.yellow - LEQVIO 284mg / 1.5mL Solution for Injection

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            References

            Best studies we found

            Dana, H., et al. (2017). Molecular mechanisms and biological functions of siRNA. International Journal of Biomedical Science.

            McGowan, M. P., et al. (2019). Diagnosis and treatment of heterozygous familial hypercholesterolemia. Journal of the American Heart Association.

            Merćep, I., et al. (2022). Advantages and disadvantages of inclisiran: A small interfering ribonucleic acid molecule targeting PCSK9-A narrative review. Cardiovascular Therapeutics.

            View All References (7)

            National Human Genome Research Institute. (2025). Gene.

            Novartis Pharmaceuticals Corporation. (2025). Leqvio- inclisiran injection, solution [package insert]. DailyMed.

            Ray, K. K., et al. (2020). Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol. The New England Journal of Medicine.

            Ray, K. K., et al. (2023). Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): Results from the 4-year open-label extension of the ORION-1 trial. The Lancet Diabetes & Endocrinology.

            Shapiro, M. D., et al. (2018). PCSK9: From basic science discoveries to clinical trials. Circulation Research.

            Sugiyama, T., et al. (2014). Different time trends of caloric and fat intake between statin users and nonusers among US adults: Gluttony in the time of statins? Journal of the American Medical Association Internal Medicine.

            Taub, P. R., et al. (2025). Safety and lipid-lowering efficacy of inclisiran monotherapy in patients without ASCVD: The VICTORION-Mono randomized clinical trial. Journal of the American College of Cardiology.

            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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