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Compare Leqvio vs. Repatha

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Leqvio (inclisiran)
    Repatha (evolocumab)
  • Leqvio (inclisiran)
    Repatha (evolocumab)

  • Summary of Leqvio vs. Repatha

    Summary for siRNA
    Prescription only

    Leqvio (inclisiran) is an injectable medication used to treat high cholesterol in adults. It's used together with a statin and with a heart-healthy diet. Leqvio (inclisiran) works as a small interfering RNA (siRNA) to help lower cholesterol. It's given as an injection under your skin and it must be given by a healthcare professional. After the first two starter doses, the injection is given twice a year. Side effects aren't common. But they can include joint pain and reactions at the injection site like pain and redness.

    Summary for PCSK9 inhibitor
    Prescription only

    Repatha (evolocumab) is a PCSK9 inhibitor that's used to treat high cholesterol in adults and certain children. It also helps lower the risk of heart attack and stroke for adults with heart disease. Repatha (evolocumab) is typically used when you're having trouble managing cholesterol levels with a heart-healthy diet or with other cholesterol medications (like statins). Repatha (evolocumab) is an injection under the skin that's given either once every 2 weeks or once every month. Repatha (evolocumab) side effects can include discomfort near the injection site and cold- or flu-like symptoms.

  • Indications of Leqvio vs. Repatha

    Indications for
    •High cholesterol, including heterozygous familial hypercholesterolemia (HeFH), in adults - as an add-on to a heart-healthy diet and statin therapy
    Indications for
    •High cholesterol in adults
    •Inherited condition causing extremely high cholesterol (heterozygous and homozygous familial hypercholesterolemia) in people aged 10 years and older
    •Lower the risk of heart attack, stroke, and the need for heart procedures (like stent placement) in adults with known heart disease

  • Pros and Cons of Leqvio vs. Repatha

    Pros and Const for siRNA
    Pros
    •Helps lower "bad" cholesterol by about 50% when used with a statin
    •Given twice a year (after two starter doses)
    •Few side effects
    Cons
    •Must be given as an injection under the skin by a healthcare professional at their clinic
    •Must be used with statin therapy
    •Doesn't replace having a balanced diet and regular exercise plan to help lower cholesterol levels
    Pros and Const for PCSK9 inhibitor
    Pros
    •Only taken either every 2 weeks or once every month
    •Can help lower your cholesterol levels if other medications haven't worked well enough
    •Can use for children as young as 10 years old with familial hypercholesterolemia
    •Available in multiple forms (prefilled syringe, prefilled autoinjector, or single-use on-body infusor)
    Cons
    •Only available as an injection
    •Long-term side effects aren't fully known (compared to statins)
    •No lower-cost generic available (brand-name medication only)

  • Common Side Effects of Leqvio vs. Repatha

    Common Side Effects for
    •Injection site reactions (e.g., pain, redness, rash; 8%)
    Common Side Effects for
    •Common cold symptoms (11%)
    •Flu-like symptoms (8%)
    •Back pain (6%)
    •Redness, pain, or bruising at the injection site (6%)

  • Warnings of Leqvio vs. Repatha

    Common Side Effects for
    Common Side Effects for
    •Allergic reaction

  • Prices with our coupons for Leqvio vs. Repatha

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    Learn more about Repatha

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