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Compare Leqvio vs. Repatha

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Leqvio (inclisiran)
    Repatha (evolocumab)
  • Leqvio (inclisiran)
    Repatha (evolocumab)

  • Summary of Leqvio vs. Repatha

    Summary for siRNA
    Prescription only

    Leqvio (inclisiran) is an injectable medication used to treat high cholesterol in adults. It's used together with a statin and with a heart-healthy diet. Leqvio (inclisiran) works as a small interfering RNA (siRNA) to help lower cholesterol. It's given as an injection under your skin and it must be given by a healthcare professional. After the first two starter doses, the injection is given twice a year. Side effects aren't common. But they can include joint pain and reactions at the injection site like pain and redness.

    Summary for PCSK9 inhibitor
    Prescription only

    Repatha (evolocumab) is a PCSK9 inhibitor that's given as an injection under the skin. It treats high cholesterol in adults and certain children. It works best with a heart-healthy diet and regular exercise. Repatha (evolocumab) also helps lower the risk of events like heart-related death, heart attack, and stroke in adults at risk. The medication is injected either once every 2 weeks or once a month. Side effects can include common cold symptoms and discomfort at the injection site.

  • Indications of Leqvio vs. Repatha

    Indications for
    •High cholesterol, including heterozygous familial hypercholesterolemia (HeFH), in adults - as an add-on to a heart-healthy diet and statin therapy
    Indications for
    •High cholesterol in adults
    •Heterozygous familial hypercholesterolemia (HeFH) in people ages 10 years and older
    •Homozygous familial hypercholesterolemia (HoFH) in people ages 10 years and older
    •Lowering the risk of heart-related death, heart attack, stroke, hospitalization for chest pain, and the need for heart procedures in adults at risk

  • Pros and Cons of Leqvio vs. Repatha

    Pros and Const for siRNA
    Pros
    •Helps lower "bad" cholesterol by about 50% when used with a statin
    •Given twice a year (after two starter doses)
    •Few side effects
    Cons
    •Must be given as an injection under the skin by a healthcare professional at their clinic
    •Must be used with statin therapy
    •Doesn't replace having a balanced diet and regular exercise plan to help lower cholesterol levels
    Pros and Const for PCSK9 inhibitor
    Pros
    •Taken once every 2 weeks or once a month
    •Can use for inherited cholesterol conditions in kids 10 years and up
    •Has different injection devices to choose from (prefilled syringe, autoinjector, or on-body infusor)
    Cons
    •Must give as an injection under the skin
    •Might cause reactions at the injection site like redness and pain
    •Caution use in people with a latex allergy for syringes and autoinjectors (some have parts made with natural rubber)

  • Common Side Effects of Leqvio vs. Repatha

    Common Side Effects for
    •Injection site reactions (e.g., pain, redness, rash; 8%)
    Common Side Effects for
    •Common cold symptoms (4%)
    •Back pain (2%)
    •Upper respiratory tract infection (2%)
    •Joint pain (2%)
    •Nausea (2%)
    •Tiredness (2%)

  • Warnings of Leqvio vs. Repatha

    Common Side Effects for
    Common Side Effects for
    •Allergic reactions

  • Prices with our coupons for Leqvio vs. Repatha

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    Learn more about Repatha

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