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Mifepristone Coupon - Mifepristone 300mg tablet

mifepristone

Generic Korlym
Used for Cushing's Syndrome
Used for Cushing's Syndrome

Korlym, also known by its generic name mifepristone, is a cortisol receptor blocker. It's used to manage high blood sugar levels in certain adults with Cushing's syndrome who have Type 2 diabetes. This medication is an option for people if they can't have surgery or if surgery didn't help with their condition. Korlym (mifepristone) is a tablet that's taken by mouth once per day with food. Dosage adjustments are based on how well the medication is working. It also depends on whether you have unpleasant side effects. Common side effects include nausea, fatigue, and headache.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Cydnee Ng, PharmD
Last reviewed on December 13, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesImagesReferencesPricesMedicare
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What is Korlym (mifepristone)?

What is Korlym (mifepristone) used for?

How Korlym (mifepristone) works

When you have Cushing's syndrome, your body makes too much cortisol. Cortisol is your body's natural "stress hormone." Too much cortisol in the body can cause symptoms like high blood sugar.

Korlym (mifepristone) is a glucocorticoid receptor blocker. It's also known as a cortisol receptor blocker. The medication stops cortisol from attaching to its receptors. This helps lower blood sugar in people with Cushing's syndrome.

Are you looking for information on mifepristone (Mifeprex) for medical abortion instead?

Drug Facts

Common BrandsKorlym
Drug ClassCortisol receptor blocker
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Korlym (mifepristone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (48%)
  • Fatigue (48%)
  • Headache (44%)
  • Low potassium levels (34%)
  • Joint pain (30%)
  • Vomiting (26%)
  • Swelling in the hands, ankles, or feet (26%)
  • High blood pressure (24%)
  • Dizziness (22%)
  • Low appetite (20%)
  • Dry mouth (18%)

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: trouble breathing; hives; swelling of your face, lips, tongue, or throat
  • Low potassium levels: irregular heart beat, fatigue, muscle weakness, high blood pressure
  • Abnormal heart rhythm (QT prolongation): chest pounding, chest pain, shortness of breath, feeling faint or lightheaded

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Excessively heavy vaginal bleeding

unusual tiredness or weakness

Incidence not known

Chest pain or discomfort

confusion

cough or hoarseness

fast, weak pulse

fever or chills

lower back or side pain

pain or discomfort in the arms, jaw, back, or neck

painful or difficult urination

pale, cold, or clammy skin

shortness of breath

sudden increase in stomach or shoulder pain

sweating

unusual or large amount of vaginal bleeding

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach pain or uterine cramping

back pain

diarrhea

dizziness

headache

nausea or vomiting

Less common

Acid or sour stomach

anxiety

belching

cough

fainting or lightheadedness when getting up from a lying or sitting position

fever

flu-like symptoms

headache

heartburn

increased clear or white vaginal discharge

indigestion

itching of the vagina or genital area

lack or loss of strength

pain during sexual intercourse

pain or tenderness around the eyes and cheekbones

pale skin

shaking chills

stomach discomfort, upset, or pain

stuffy or runny nose

tightness of the chest

trouble sleeping

troubled breathing

troubled breathing, exertional

unusual bleeding or bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Korlym (mifepristone)

thumbs-up

Pros

A possible option for people with Cushing's syndrome who can't have surgery or who've had surgery without success

Taken by mouth just once per day

thumbs-down

Cons

Not a first-choice option because it has many side effects and drug interactions

Not reliable to monitor cortisol levels during treatment

Not safe for people who are pregnant

pharmacist-tips

Pharmacist tips for Korlym (mifepristone)

pharmacist

  • Take Korlym (mifepristone) at the same time every day. Be sure to take it with food to help your body absorb the medication.

    • Don't split, crush, or chew the Korlym (mifepristone) tablets. Otherwise, it could affect the way your body absorbs the medication. Contact your prescriber if you're having trouble swallowing Korlym (mifepristone).

      • Regularly follow up with your prescriber about your treatment with Korlym (mifepristone). Let them know about any symptom improvement or bothersome side effects. Also get any blood tests that your prescriber recommends (for example, for checking blood sugar or insulin levels). This information is helpful for your prescriber in deciding whether you need any dose adjustments.

        • Make sure your care team knows about all your prescription and over-the-counter medications. Also, don't start any medications while you're taking Korlym (mifepristone) without asking your care team if it's safe first. Korlym (mifepristone) can interact with many medications. This can affect how well your medications work or put you at higher risk for side effects.

          • Tell your prescriber if you're taking any steroid medications. Korlym (mifepristone) might block the effects of steroids. This can make the steroid work less well for the condition you're taking it for. Depending on why you need steroids, your care team might consider a different medication for you instead of Korlym (mifepristone).

            • Use nonhormonal birth control, such as condoms or a spermicide, while you're taking Korlym (mifepristone) if you're sexually active and if you can get pregnant. This medication can make hormonal birth control work less well at preventing pregnancy. It's important to take steps to prevent pregnancy during treatment because Korlym (mifepristone) can cause pregnancy loss.

              faqs

              Frequently asked questions about Korlym (mifepristone)

              How long does it take for Korlym (mifepristone) to work?
              Everyone's experience with Korlym (mifepristone) can be different. So, it's hard to say when exactly the medication starts working for you. In a clinical study, some people had improvements in blood sugar and cholesterol levels, blood pressure, and other symptoms of Cushing's syndrome within 6 weeks of treatment. But it can take longer for other people to notice benefits from the medication. Continue to take Korlym (mifepristone) exactly as prescribed. Speak with your prescriber if you have concerns about how well the medication is working for you and how long it's taking to see improvements. Your prescriber might raise your dose or make adjustments to your treatment plan.
              When is the best time to take Korlym (mifepristone)?
              You can take Korlym (mifepristone) at any time of the day. Take note of how the medication makes you feel after you take it. This might affect when you decide to take the medication. For example, you might want to take Korlym (mifepristone) at night if it makes you too sleepy throughout the day. But taking the medication earlier in the day might be a better option if you have side effects like anxiety or diarrhea to avoid disrupting your sleep. Take Korlym (mifepristone) at the same time every day, no matter what time of day you end up choosing. Talk to a member of your healthcare team if you're interested in changing when you take the medication during treatment.
              Does Korlym (mifepristone) lower cortisol?
              No, Korlym (mifepristone) doesn't lower cortisol levels. It only works to block the effects of cortisol, such as high blood sugar. This means that checking the levels of cortisol in your blood isn't a good way to see how well Korlym (mifepristone) is working for you or to check for certain side effects. Other medications that can lower cortisol levels are recommended for Cushing's syndrome.
              Does Korlym (mifepristone) cause weight loss?
              It's not clear whether Korlym (mifepristone) directly causes weight loss. This medication can cause side effects like low appetite, nausea, vomiting, and diarrhea. It's possible that these side effects might contribute to any weight loss during treatment. But also keep in mind that weight loss is one sign of symptom improvement in Cushing's syndrome. Some people who took part in a small study lost at least 5% of their body weight after taking Korlym (mifepristone) for an average of about 2.5 years. Work with your care team to make a plan that includes a nutritious and balanced diet to help maintain a healthy weight. Speak with your prescriber if you have concerns about your weight.
              Does Korlym (mifepristone) cause itching?
              Itching is a possible side effect of Korlym (mifepristone), but it's rare. Contact your prescriber if any itchiness that you experience gets too bothersome. Your prescriber might lower your dose. They might also recommend medications like an antihistamine to try to relieve the itching.
              Does Korlym (mifepristone) make you sleepy?
              Yes, some people can feel sleepy after they take Korlym (mifepristone). In clinical studies, about 10% of people who took the medication reported sleepiness as a side effect. Sleepiness from Korlym (mifepristone) can be more intense if you're taking other medications that can make you tired or if you drink alcohol with Korlym (mifepristone). Don't drive or do anything that requires concentration until you know how Korlym (mifepristone) affects you. Let your prescriber know if Korlym (mifepristone) is making you too sleepy.
              What's the difference between Korlym and Mifeprex?
              Both Korlym and Mifeprex are medications containing the active ingredient mifepristone. But they're FDA approved for very different things. Korlym is used for Cushing's syndrome. And Mifeprex is used for medical abortion (using medications to end a pregnancy). These brand names contain different doses of mifepristone. At lower doses such as with Mifeprex, the medication mainly blocks progesterone, an important hormone for maintaining a pregnancy. But at higher doses like with Korlym, it also blocks the cortisol receptor. Keep in mind that Korlym can cause pregnancy loss just like Mifeprex can. So if you're sexually active and you can become pregnant, you'll need to confirm that you're not pregnant with a pregnancy test before you start Korlym (mifepristone). You'll also need to use nonhormonal birth control to prevent pregnancy during treatment.
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              What are the risks and warnings for Korlym (mifepristone)?

              Korlym (mifepristone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Loss of pregnancy

              Korlym (mifepristone) can cause a loss of a pregnancy. To lower the chance of this happening during treatment, you must take a pregnancy test before you start Korlym (mifepristone) if you can become pregnant. You'll also need to take a pregnancy test if you've stopped taking the medication for at least 14 days. You can take the medication once it's confirmed that you're not pregnant.

              While you're taking Korlym (mifepristone), you'll need to use a form of nonhormonal birth control (like condoms) if you're sexually active. Continue to use these forms of birth control for at least 1 month after your last dose of Korlym (mifepristone). Don't use hormonal birth control because Korlym (mifepristone) makes it not work as well. This can lead to an unexpected pregnancy. Ask your healthcare professional (HCP) or pharmacist if you have questions about how to prevent pregnancy.

              Stop taking Korlym (mifepristone) and tell your HCP right away if you think you're pregnant.

              risk-warning

              Must use nonhormonal birth control if you're sexually active and able to get pregnant

              Use a form of nonhormonal birth control, like condoms or Paragard (the copper intrauterine device), while you're taking Korlym (mifepristone) if you're sexually active. Korlym (mifepristone) can make hormonal birth control work less well, which can raise the risk of having an unexpected pregnancy.

              It's important to prevent pregnancy while you're taking Korlym (mifepristone) and for a month about treatment ends. This medication can cause pregnancy loss. Stop taking Korlym (mifepristone) and let your prescriber know right away if you think you're pregnant.

              risk-warning

              Low adrenal hormone levels (adrenal insufficiency)

              People who take Korlym (mifepristone) can develop adrenal insufficiency (when the adrenal gland doesn't make enough of its natural hormones). The medication stops cortisol, one of the hormones that the adrenal gland makes, from working.

              Adrenal insufficiency can lead to symptoms like tiredness, weakness, nausea, vomiting, low blood pressure, and low blood sugar levels. Let your care team know right away if you have any symptoms of adrenal insufficiency while you're taking Korlym (mifepristone). You might need to stop Korlym (mifepristone) and get treated with corticosteroids.

              risk-warning

              Vaginal bleeding and changes to the uterine lining

              • Risk factors: Bleeding problems | Taking blood thinners

                In addition to being a cortisol receptor blocker, Korlym (mifepristone) is also a progesterone receptor blocker. When the medication blocks the hormone progesterone in the body, it can cause bleeding from the vagina. It can also make the uterus lining thicken.

                Let your prescriber know if you have a history of bleeding problems or you're taking any blood thinners. These situations might raise your risk for vaginal bleeding. Contact your prescriber or obstetrician-gynecologist (OB-GYN) if you notice any unusual vaginal bleeding after you start Korlym (mifepristone).

                risk-warning

                Low potassium levels

                Korlym (mifepristone) can cause low potassium levels at any time during treatment. Your prescriber will check your potassium levels before you start taking Korlym (mifepristone). They'll also check your potassium regularly throughout treatment, such as a few weeks after you start treatment and after your dose gets raised.

                Your prescriber might recommend that you take a potassium supplement to raise your levels if you need it. You might need additional medications to help manage this side effect if potassium supplements aren't enough.

                Let your prescriber know if you feel symptoms of low potassium, such as muscle aches or cramps, nausea, unusual fatigue, or abnormal heartbeats, while you're taking Korlym (mifepristone).

                risk-warning

                Life-threatening abnormal heart rhythm (QT prolongation)

                • Risk factors: Taking other medications that cause QT prolongation | Personal or family history of long QT syndrome | History of heart failure or other heart problems | Low potassium or magnesium levels

                  Korlym (mifepristone) can affect your heart rhythm by lengthening the time it takes for the heart to pump and then relax. This is known as QT prolongation (or long QT syndrome), which can be life-threatening.

                  Your risk for QT prolongation can be higher in certain situations. Examples include having abnormal electrolyte levels or heart rhythm problems. In addition, you might be at risk if you take other medications that can cause QT prolongation along with Korlym (mifepristone).

                  To lower your risk for QT prolongation, your prescriber will make sure that you're taking the lowest possible dose of Korlym (mifepristone) that works for you. They might want to check your heart rhythm from time to time.

                  Call 911 right away if you feel your chest pounding; feel short of breath, faint, or lightheaded; or have chest pain while you're taking Korlym (mifepristone). These can be signs of heart rhythm problems.

                  risk-warning

                  Interactions with other medications

                  Korlym (mifepristone) can interact with many other medications. Some of these drug interactions can raise the levels of mifepristone in the blood, which can put you at risk for side effects. Korlym (mifepristone) can also block the effects of steroids and make them work less well.

                  Share with your healthcare team an updated list of medications that you take or plan to take with Korlym (mifepristone). Include any prescription medications, over-the-counter products, and herbal supplements.

                  Your care team can check for drug interactions and weigh any risks and benefits. Your prescriber might need to make changes to your treatment plan to keep to safe. These changes can include stopping certain medications or making dose adjustments.

                  dosage

                  Korlym (mifepristone) dosage forms

                  Typical dosing for Korlym (mifepristone)

                  The typical starting dose is 300 mg by mouth once per day with a meal.

                  Your prescriber might raise the dose every 2 to 4 weeks based on how well the medication is helping your condition. Your prescriber might also adjust the dose depending on the side effects you have from the medication.

                  The maximum dose is 1,200 mg by mouth once per day.

                  Note: Your dose might differ if you have liver problems or kidney problems. In addition, your dose might differ if you're also taking a medication that interacts with Korlym (mifepristone).

                  interactions

                  Interactions between Korlym (mifepristone) and other drugs

                  Korlym (mifepristone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Korlym (mifepristone). Please note that only the generic name of each medication is listed below.

                  Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                  Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                  Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                  Korlym (mifepristone) contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Korlym (mifepristone) will not be safe for you to take.
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                  What are alternatives to Korlym (mifepristone)?

                  There are a number of medications that your doctor can prescribe in place of Korlym (mifepristone). Compare a few possible alternatives below.
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                  Korlym (mifepristone) images

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                  References

                  Best studies we found

                  Brown, D. R., et al. (2020). Clinical management of patients with Cushing syndrome treated with mifepristone: Consensus recommendations. Clinical Diabetes and Endocrinology.

                  Corcept Therapeutics Incorporated. (2024). Korlym- mifepristone tablet [package insert]. DailyMed.

                  Fein, H. G., et al. (2015). Sustained weight loss in patients treated with mifepristone for Cushing's syndrome: A follow-up analysis of the SEISMIC study and long-term extension. BioMed Central Endocrine Disorders.

                  View All References (10)

                  Fleseriu, M., et al. (2021). Consensus on diagnosis and management of Cushing's disease: A guideline update. The Lancet Diabetes & Endocrinology.

                  Katznelson, L., et al. (2014). Global clinical response in Cushing's syndrome patients treated with mifepristone. Clinical Endocrinology.

                  MedlinePlus. (2023). Cushing syndrome.

                  Molitch, M. E. (2022). Glucocorticoid receptor blockers. Pituitary.

                  National Heart, Lung, and Blood Institute. (2022). Long QT syndrome.

                  National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Cushing’s syndrome.

                  National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Definition & facts of adrenal insufficiency & Addison’s disease.

                  National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & causes of adrenal insufficiency & Addison’s disease.

                  U.S. Food and Drug Administration. (2021). Grapefruit juice and some drugs don’t mix.

                  You and Your Hormones. (2019). Cortisol.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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