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Hyrimoz

Used for Psoriasis, Plaque Psoriasis, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Ankylosing Spondylitis, Hidradenitis Suppurativa, Juvenile Idiopathic Arthritis, Uveitis

Hyrimoz (adalimumab or adalimumab-adaz) is an injection used to treat many different autoimmune conditions (e.g., different types of arthritis, Crohn's disease (CD), ulcerative colitis (UC), and plaque psoriasis). Hyrimoz (adalimumab) is a biosimilar to Humira (adalimumab), but it's not FDA approved to treat all of the same conditions. But it won't be available in the United States until September 2023.

Reviewed by:

Kristianne Hannemann, PharmD

Daisy Chau, PharmD

Last reviewed on December 21, 2022

Basics Side effects Pros & cons Pharmacist tips FAQs Warnings Dosage Interactions Cost Alternatives Latest news Images Prices Medicare

What is Hyrimoz (adalimumab)?

What is Hyrimoz (adalimumab) used for?

Rheumatoid arthritis (RA) - adults only
Juvenile idiopathic arthritis (JIA) - people age 4 and older
Psoriatic arthritis (PsA) - adults only
Ankylosing spondylitis (AS) - adults only
Crohn's disease (CD) - adults only
Ulcerative colitis (UC) - adults only
Plaque psoriasis - adults only
Hidradenitis suppurativa - adults only
Uveitis - adults only

How Hyrimoz (adalimumab) works

Hyrimoz (adalimumab) is a biologic disease-modifying antirheumatic drug (DMARD). It works by blocking tumor necrosis factor (TNF), a protein in your body that plays a role in inflammation. By blocking TNF, Hyrimoz (adalimumab) lowers inflammation in different parts of your body.

Are you looking for information on Humira (adalimumab) instead?

Drug Facts

Common BrandsHyrimoz

Drug ClassBiologic DMARD

Controlled Substance ClassificationNot a controlled medication

Generic StatusNo lower-cost generic available

AvailabilityPrescription only

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Avg retail price

$6586.59(save 79.96%)

GoodRx discount

$1319.90

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What are the side effects of Hyrimoz (adalimumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Injection site reaction (20%)
Upper respiratory tract infection (17%)
Headache (12%)
Rash (12%)
Sinus inflammation (11%)
Accidental injury (10%)
Nausea (9%)
Urinary tract infection (UTI) or bladder infection (8%)

Other Side Effects

High cholesterol
High blood pressure
Back pain
Stomach pain
Hair loss
Blood in the urine
Flu-like symptoms

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.

Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
Low blood cell counts: fever that doesn't go away, easy bruising or bleeding, pale skin
Severe allergic reaction: hives, rash, trouble breathing, swelling of your face, eyes, lips, or mouth
Heart failure: shortness of breath, sudden weight gain, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness
Liver problems: feeling tired, vomiting, yellow skin or whites of the eyes, stomach pain

Source: FDA

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

cough

ear congestion

gas with stomach pain

hoarseness

lightheadedness

loss of voice

lower back or side pain

muscle aches and pains

pain or tenderness around the eyes or cheekbones

rapid and sometimes shallow breathing

shivering

stomach fullness

stuffy nose

sunken eyes

thirst

trouble sleeping

warmth on the skin

wrinkled skin

Less common

Abnormal vaginal bleeding or discharge

agitation

arm, back, or jaw pain

black, tarry stools

bleeding from the gums or nose

blindness

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the stool or change in bowel habits

bloody or cloudy urine

blurred vision

broken bones

change in size, shape, or color of an existing mole

change in skin color

chest pain, tightness, or heaviness

chills

clear or bloody discharge from the nipple

cold hands and feet

confusion

constipation

cough

coughing or spitting up blood

decreased urination

decreased vision

depression

difficulty with breathing

difficulty, burning, or painful urination

dimpling of the breast skin

dizziness

drowsiness

eye pain

fainting

fast, slow, or irregular heartbeat

fever

forgetfulness

frequent urge to urinate

general feeling of illness

hair loss

headache

hives, itching, skin rash

increased thirst

inverted nipple

irregular breathing

irregular pulse

irritability

light colored stools

loss of appetite

lump in the breast or under your arm

lump or swelling in the stomach

mole that leaks fluid or bleeds

muscle cramps or spasms

nausea

new mole

night sweats

no blood pressure or pulse

noisy breathing

numbness or tingling in your arms, legs, or face

pain, redness, or swelling in the arms or legs without any injury present

pale skin

persistent non-healing sore on your skin

pink growth

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised, firm, or bright red patch

redness or swelling of the breast

seeing or hearing things that are not there

seizures

sharp back pain just below your ribs

shiny bump on your skin

slurred speech or problems with swallowing

sneezing

sore on the skin of the breast that does not heal

sore throat

sores, ulcers, or white spots on the lips or mouth

spitting up blood

stiff neck

stomach pain

stopping of the heart

sudden high fever or low grade fever for months

sweating

swelling of the face, fingers, feet, or lower legs

swollen glands

swollen neck veins

tiredness

trouble breathing

trouble thinking

unconsciousness

unexplained bruising or bleeding

unpleasant breath odor

unusual tiredness or weakness

unusual weight gain or loss

visual disturbances

vomiting

vomiting of blood or material that looks like coffee grounds

yellow skin or eyes

Incidence not known

Blistering, peeling, or loosening of the skin

diarrhea

inability to move the arms and legs

joint or muscle pain

pinpoint red spots on the skin

red skin lesions, often with a purple center

red, irritated eyes

red, scaling, or crusted skin

sudden numbness and weakness in the arms and legs

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bladder pain

bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

pounding in the ears

Less common

Abnormal healing

decrease in height

difficulty with moving

difficulty with walking

dry mouth

heartburn

indigestion

loss of hearing

loss of strength or energy

menstrual changes

muscle or joint stiffness, tightness, or rigidity

muscle pain or weakness

pain in the back, ribs, arms, or legs

shakiness in the legs, arms, hands, and feet

swelling or redness in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pros and cons of Hyrimoz (adalimumab)

Pros

Works to treat many autoimmune conditions

Can be stored at room temperature for up to 14 days if needed, like for traveling

Typically only injected a few times a month

Can be given at home (if your provider says it's safe to do so)

Available as prefilled syringes and pen for convenience

Cons

Raises risk for infections

Might be difficult to use for some people

Some products contain latex, which might not be the best option for people with a latex allergy

Unknown if safe in pregnant or breastfeeding females

Can't receive live vaccines when taking the medication

Pharmacist tips for Hyrimoz (adalimumab)

Before using Hyrimoz (adalimumab) at home, you should receive injection training from your healthcare provider or care team. If you haven't, contact the clinic or call 1-800-525-8747. Don't try to give yourself an Hyrimoz (adalimumab) injection until you've been shown how to do it safely.

Mark your calendar when your dose of Hyrimoz (adalimumab) is due to help you remember to take it. If you happen to miss a dose, inject a dose as soon as possible and then continue with your regular dosing schedule.

When ready for your injection, take Hyrimoz (adalimumab) out of the refrigerator and let it warm up to room temperature for about 15 to 30 minutes. This will help lower discomfort with the injection. Never warm it up by putting it in the microwave or in hot water because this could damage the medication.

Keep unused Hyrimoz (adalimumab) in its original container and in the refrigerator. You can also keep Hyrimoz (adalimumab) at room temperature for up to 14 days. Throw it away if it hasn't been used after keeping it at room temperature for this time because it might not work well anymore.

Throw away used needles, syringes, and pens in a sharps container to prevent needlestick injuries. You can also use a heavy-duty plastic container you have at home. Check your local laws and guidelines for how to dispose of your container once it's almost full.

Before getting any vaccines, let your provider or pharmacist know you're taking Hyrimoz (adalimumab). It's recommended to avoid live vaccines while you're taking this medication.

Frequently asked questions about Hyrimoz (adalimumab)

When will Hyrimoz (adalimumab) be available?

Hyrimoz (adalimumab) was approved by the FDA in 2018, but it won't become available in the United States until September 2023.

Is Hyrimoz (adalimumab) the same as Humira (adalimumab)?

Hyrimoz (adalimumab) is a biosimilar of Humira (adalimumab), meaning it has a comparable structure and works similarly to Humira. Biosimilars are sort of like generics, but they aren't identical to the original biologic. Hyrimoz (adalimumab) isn't FDA approved to treat all age groups within a condition that Humira (adalimumab) is.

Where do I inject Hyrimoz (adalimumab)?

You should inject Hyrimoz (adalimumab) in the fatty area under your skin, either on the front of your thighs or your lower stomach. If you inject into your stomach, make sure the area is at least 2 inches away from your belly button. Avoid injecting the medication into skin that's red, bruised, or sore.

Can I take other arthritis medications with Hyrimoz (adalimumab)?

It's possible to take other medications that are used to treat arthritis while taking Hyrimoz (adalimumab). Some examples include methotrexate, corticosteroids, NSAIDs, and other pain medications. Discuss all of the medications you're taking with your provider so that you can come up with a treatment plan. And always rotate your injection sites each time to allow your skin to heal.

Can Hyrimoz (adalimumab) be used in children?

The only condition Hyrimoz (adalimumab) has been approved by the FDA to treat in children is juvenile idiopathic arthritis (JIA). In order to use it, your child must be at least 4 years old. Discuss with your child's if you have questions on how to use this medication safely.

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What are the risks and warnings for Hyrimoz (adalimumab)?

Hyrimoz (adalimumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Serious infections

Risk factors: Taking other medications that weaken the immune system | Older adults | Active, long-term, or an infection that keeps coming back | Traveling to high risk areas | Having other conditions that raise the risk of infection

Hyrimoz (adalimumab) can raise your risk of serious or life-threatening infections. Your risk is higher if you're an older adult, taking other medications that can weaken the immune system (e.g., methotrexate, Orencia (abatacept), Kineret (anakinra), corticosteroids), or if you have other health conditions. Before starting Hyrimoz (adalimumab), discuss your medical history with your provider, especially if you've ever had tuberculosis or hepatitis B. They'll review your risk before starting the medication. If you develop a serious infection while taking Hyrimoz (adalimumab), you might have to stop the medication in order to give your immune system a chance to fight the infection.

Cancers

Risk factors: Taking other medications that weaken the immune system | History of cancer | People with chronic obstructive pulmonary disease (COPD) with a history of smoking

There was a greater number of cancers in people taking a medication like Hyrimoz (adalimumab) when compared to people not taking them in clinical trials. Some of the most commonly reported types of cancer in people who used that medication were lymphoma, leukemia, and skin cancers. Your provider will determine your risk before starting Hyrimoz (adalimumab) and monitor you while you're taking it. Speak to your provider if you have any concerns.

Severe allergic reactions

Rarely, Hyrimoz (adalimumab) can cause severe allergic reactions, like anaphylaxis (closing of the throat). If you experience rash, hives, trouble breathing, itching, or swelling in your face or throat, get medical help right away.

Nervous system effects

Risk factors: Currently have or recently developed a nervous system condition

Although rare, Hyrimoz (adalimumab) can cause you to develop conditions that affect your nervous system, such as multiple sclerosis (MS) and Guillain-Barré syndrome. Let your provider know if you currently have nerve problems. They'll want to monitor you closely while you're taking Hyrimoz (adalimumab), since it can make them worse. If you notice numbness or tingling, weakness in your arms or legs, vision problems, or dizziness, call your provider right away.

Low blood cell counts

Although rare, some people taking medications like Hyrimoz (adalimumab) experienced having low amounts of blood cells. This can lower your body's ability to fight infections and raise your risk for bleeding. Contact your provider if you develop a fever that doesn't go away, easy bruising, pale skin, or bleeding.

Heart failure

People taking medications like Hyrimoz (adalimumab) have had new or worsening cases of heart failure. If you currently have heart failure, your provider will weigh the benefits and risks to determine if Hyrimoz (adalimumab) is right for you. Let your provider know if you start to have shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, or tiredness or weakness, as these can be signs of heart failure.

Lupus-like syndrome

Rarely, Hyrimoz (adalimumab) can cause a condition called lupus-like syndrome. Contact your provider if you experience easy bruising or bleeding, a rash, or feel unusually tired.

Hyrimoz (adalimumab) dosage forms

Typical dosing for Hyrimoz (adalimumab)

Adults

Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical starting dose is 40 mg injected under the skin every other week.
Crohn's disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week on Day 29.
Plaque psoriasis and uveitis: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg every other week starting 1 week after the first dose.
Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every week OR 80 mg every other week starting Day 29.

Children

Juvenile idiopathic arthritis: The dose will be based on your child's body weight. Typically it will be injected under the skin once every other week.

Interactions between Hyrimoz (adalimumab) and other drugs

Hyrimoz (adalimumab) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Hyrimoz (adalimumab). Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.