Estradiol (Estrace, Vivelle-Dot, Climara) is a moderately priced drug used to treat hot flashes and osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. It is covered by some Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost.

Get Estrace for as low as $348.32, which is 21% off the average retail price of $439.95 for the most common version, by using a GoodRx coupon.